Early-onset schizophrenia is associated with immune-related rare variants in a Chinese sample
Yuanxin Zhong,
Justin D. Tubbs,
Perry B.M. Leung
et al.
Abstract:BackgroundRare variants are likely to contribute to schizophrenia (SCZ), given the large discrepancy between the heritability estimated from twin and GWAS studies. Furthermore, the nature of the rare-variant contribution to SCZ may vary with the “age-at-onset” (AAO), since early-onset has been suggested as being indicative of neurodevelopment deviance.ObjectiveTo examine the association of rare deleterious coding variants in early- and adult-onset SCZ in a Chinese sample.MethodExome sequencing was performed on… Show more
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