Early Onset Region and Cell Specific Alterations of Doublecortin Expression in the CNS of Animals with Sound Damage Induced Hearing Loss

Freemyer, Andrea; Neal, Christopher; Nelson-Brantley, Jennifer; Staecker, Hinrich; Durham, Dianne

doi:10.1016/j.ibror.2019.10.003

Cited by 5 publications

(3 citation statements)

References 66 publications

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“…Increased expression of DCX in the DCN and PFL immediately after noise exposure has been previously reported [ 25 ]. In another study, the expression of DCX was evaluated one month after exposure to noise and it was reported to decrease in DG, increase in PFL, and remain unchanged in DCN [ 23 ]. The reduced expression of DCX in the DG and its unchanged expression in the DCN one month after noise exposure could indicate an important role of assessment time and possibly the brain’s compensatory ability to re-normalize plastic changes over time, which is still needed further researches to be confirmed.…”

Section: Discussionmentioning

confidence: 99%

“…The neural plasticity in tinnitus has been reported in the dorsal cochlear nucleus (DCN), inferior colliculus, hippocampus of the limbic system, parafloccular lobe (PFL) of the cerebellum, and auditory cortex [22]. Previous work has shown significant evidence of the involvement of DCN, limbic system and PFL regions in tinnitus [23][24][25]. DCN plays an important role in the production of tinnitus, and its neuronal hyperactivity has been reported as the most consistent finding of tinnitus in animal models [26,27].…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Montazeri,

Farhadi,

Majdabadi

et al. 2024

PLoS ONE

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Tinnitus is a common annoying symptom without effective and accepted treatment. In this controlled experimental study, photobiomodulation therapy (PBMT), which uses light to modulate and repair target tissue, was used to treat sodium salicylate (SS)-induced tinnitus in a rat animal model. Here, PBMT was performed simultaneously on the peripheral and central regions involved in tinnitus. The results were evaluated using objective tests including gap pre-pulse inhibition of acoustic startle (GPIAS), auditory brainstem response (ABR) and immunohistochemistry (IHC). Harmful neural plasticity induced by tinnitus was detected by doublecortin (DCX) protein expression, a known marker of neural plasticity. PBMT parameters were 808 nm wavelength, 165 mW/cm2 power density, and 99 J/cm2 energy density. In the tinnitus group, the mean gap in noise (GIN) value of GPIAS test was significantly decreased indicated the occurrence of an additional perceived sound like tinnitus and also the mean ABR threshold and brainstem transmission time (BTT) were significantly increased. In addition, a significant increase in DCX expression in the dorsal cochlear nucleus (DCN), dentate gyrus (DG) and the parafloccular lobe (PFL) of cerebellum was observed in the tinnitus group. In PBMT group, a significant increase in the GIN value, a significant decrease in the ABR threshold and BTT, and also significant reduction of DCX expression in the DG were observed. Based on our findings, PBMT has the potential to be used in the management of SS-induced tinnitus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Montazeri,

Farhadi,

Majdabadi

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

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“…While it is already known that the embryonic development of the CN subnuclei occurs in tonotopic specificity [18] and that region-specific pathologies exist in the adult organism [19][20][21][22][23][24], it has not yet been clarified whether there is a postnatal neurogenic potential in all compartments. The question arose whether regional differences exist, which could play a role in regeneration after damage to the auditory pathway.…”

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confidence: 99%

Different Neurogenic Potential in the Subnuclei of the Postnatal Rat Cochlear Nucleus

Voelker¹,

Engert²,

Voelker³

et al. 2021

Stem Cells International

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In patients suffering from hearing loss, the reduced or absent neural input induces morphological changes in the cochlear nucleus (CN). Neural stem cells have recently been identified in this first auditory relay. Afferent nerve signals and their impact on the immanent neural stem and progenitor cells already impinge upon the survival of early postnatal cells within the CN. This auditory brainstem nucleus consists of three different subnuclei: the anteroventral cochlear nucleus (AVCN), the posteroventral cochlear nucleus (PVCN), and the dorsal cochlear nucleus (DCN). Since these subdivisions differ ontogenetically and physiologically, the question arose whether regional differences exist in the neurogenic niche. CN from postnatal day nine Sprague-Dawley rats were microscopically dissected into their subnuclei and cultivated in vitro as free-floating cell cultures and as whole-mount organ cultures. In addition to cell quantifications, immunocytological and immunohistological studies of the propagated cells and organ preparations were performed. The PVCN part showed the highest mitotic potential, while the AVCN and DCN had comparable activity. Specific stem cell markers and the ability to differentiate into cells of the neural lineage were detected in all three compartments. The present study shows that in all subnuclei of rat CN, there is a postnatal neural stem cell niche, which, however, differs significantly in its potential. The results can be explained by the origin from different regions in the rhombic lip, the species, and the various analysis techniques applied. In conclusion, the presented results provide further insight into the neurogenic potential of the CN, which may prove beneficial for the development of new regenerative strategies for hearing loss.

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Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo

Yadav

Verhaegen

Filis

et al. 2022

Environment International

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Early Onset Region and Cell Specific Alterations of Doublecortin Expression in the CNS of Animals with Sound Damage Induced Hearing Loss

Cited by 5 publications

References 66 publications

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Photobiomodulation therapy in improvement of harmful neural plasticity in sodium salicylate-induced tinnitus

Different Neurogenic Potential in the Subnuclei of the Postnatal Rat Cochlear Nucleus

Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo

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