Early onset of forced impaired forelimb use causes recovery of forelimb skilled motor function but no effect on gross sensory-motor function after capsular hemorrhage in rats

Ishida, Atsushi; Tamakoshi, Keigo; Hamakawa, Michiru; Shimada, Haruka; Nakashima, Hiroyuki; Masuda, Tadashi; Hida, Hideki; Ishida, Kenji

doi:10.1016/j.bbr.2011.06.036

Cited by 22 publications

(23 citation statements)

References 41 publications

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“…As has already been reported [13], we clearly showed that early CIMT improved motor function of affected forelimbs in rat models of subcortical hemorrhage. Beneficial effects of early-phase CIMT have also been reported in other models of subcortical lesion such as CST injury [8,14].…”

Section: Discussionsupporting

confidence: 89%

“…A rat model of subcortical hemorrhage was made by injection of collagenase type IV (Sigma-Aldrich, St Louis, MO, USA) into the globus pallidus near the internal capsule (IC) [13,18,19]. Each rat was anesthetized with sodium pentobarbital (45 mg/kg, i.p.)…”

Section: Subcortical Hemorrhage Model (Ic Hemorrhage Model)mentioning

confidence: 99%

“…Beginning CIMT too early after a stroke has been reported to be detrimental, with immediate treatment inducing local cortical hyperthermia or exaggeration of neural injury [10][11][12]. In contrast, other studies have shown acute CIMT application to promote functional recovery after spinal hemisection, and ischemic stroke including subcortical hemorrhage near the internal capsule (IC) [8,[13][14][15]. Thus, evidence regarding the effectiveness of CIMT initiated soon after stroke is contradictory.…”

Section: Introductionmentioning

confidence: 99%

“…We previously developed an ICH model that has a small hemorrhage near the internal capsule (IC), but with severe motor dysfunction [13,18]. Because only a small percentage of unilateral CST remains undamaged in this model, it is useful for investigating how CIMT…”

Section: Introductionmentioning

confidence: 99%

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Early constraint-induced movement therapy promotes functional recovery and neuronal plasticity in a subcortical hemorrhage model rat

Ishida

Misumi

Ueda

et al. 2015

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 89%

Section: Subcortical Hemorrhage Model (Ic Hemorrhage Model)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Early constraint-induced movement therapy promotes functional recovery and neuronal plasticity in a subcortical hemorrhage model rat

Ishida

Misumi

Ueda

et al. 2015

Behavioural Brain Research

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“…Injecting vasoconstricting agents 41,42 or targeting photocoagulation 43,45 directly at structures supplied by the anterior choroidal artery that contain the white matter tracts controlling the forelimb such as the PLIC may be the most straightforward approach to recreating ICARE-like ischemic stroke lesions in animals. There is also a preclinical model for ICH that targets the internal capsule 46 . This capsular injection model in the rat produces motor weakness with hematoma volumes (~10 mm 3 ) similar to the relative lesion volume in the ICARE cohort and may therefore be preferred over the striatal model for testing motor rehabilitation strategies.…”

Section: Discussionmentioning

confidence: 99%

Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models

Edwardson

Wang

Liu

et al. 2017

Neurorehabil Neural Repair

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Background Stroke patients with mild-moderate upper extremity (UE) motor impairments and minimal sensory and cognitive deficits provide a useful model to study recovery and improve rehabilitation. Laboratory-based investigators use lesioning techniques for similar goals. Objective Determine whether stroke lesions in an UE rehabilitation trial cohort match lesions from the preclinical stroke recovery models used to drive translational research. Methods Clinical neuroimages from 297 participants enrolled in the Interdisciplinary Comprehensive Arm Rehabilitation Evaluation (ICARE) study were reviewed. Images were characterized based on lesion type (ischemic or hemorrhagic), volume, vascular territory, depth (cortical gray matter, cortical white matter, subcortical), old strokes, and leukoaraiosis. Lesions were compared with those of preclinical stroke models commonly used to study upper limb recovery. Results Among the ischemic stroke participants, median infarct volume was 1.8 mL, with most lesions confined to subcortical structures (61%) including the anterior choroidal artery territory (30%) and the pons (23%). Of ICARE participants, <1 % had lesions resembling proximal MCA or surface vessel occlusion models. Preclinical models of subcortical white matter injury best resembled the ICARE population (33%). Intracranial hemorrhage participants had small (median 12.5 mL) lesions that best matched the capsular hematoma preclinical model. Conclusions ICARE subjects are not representative of all stroke patients, but they represent a clinically and scientifically important subgroup. Compared to lesions in general stroke populations and widely-studied animal models of recovery, ICARE participants had smaller, more subcortically-based strokes. Improved preclinical-clinical translational efforts may require better alignment of lesions between preclinical and human stroke recovery models.

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Motor Rehabilitation Provides Modest Functional Benefits After Intracerebral Hemorrhage: a Systematic Review and Meta-Analysis of Translational Rehabilitation Studies

Fedor,

Sander,

MacLaren

et al. 2023

Transl. Stroke Res.

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Few certainties exist regarding the optimal type, timing, or dosage of rehabilitation after stroke. Despite differing injury mechanisms and recovery patterns following ischemic and hemorrhagic stroke, most translational stroke research is conducted after ischemia. As we enter the era of personalized medicine, exploring subtype-specific treatment efficacy is essential to optimizing recovery. Our objective was to characterize common rehabilitation interventions used after in vivo preclinical intracerebral hemorrhage (ICH) and assess the impact of post-ICH rehabilitation (vs. no-rehabilitation) on recovery of motor function. Following PRISMA guidelines, a systematic review (Academic Search Complete, CINAHL, EMBASE, Medline, PubMed Central) identified eligible articles published up to December 2022. Risk of bias (SYRCLE) and study quality (CAMARADES) were evaluated, and random-effects meta-analysis was used to assess treatment efficacy in recovery of forelimb and locomotor functions. Thirty articles met inclusion criteria, and 48 rehabilitation intervention groups were identified. Most used collagenase to model striatal ICH in young, male rodents. Aerobic exercise, enriched rehabilitation, and constraint-induced movement therapy represented ~ 70% of interventions. Study quality was low (median 4/10, range 2–8), and risk of bias was unclear. Rehabilitation provided modest benefits in skilled reaching, spontaneous impaired forelimb use, and locomotor function; however, effects varied substantially by endpoint, treatment type, and study quality. Rehabilitation statistically improves motor function after preclinical ICH, but whether these effects are functionally meaningful is unclear. Incomplete reporting and variable research quality hinder our capacity to analyze and interpret how treatment factors influence rehabilitation efficacy and recovery after ICH.

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Early onset of forced impaired forelimb use causes recovery of forelimb skilled motor function but no effect on gross sensory-motor function after capsular hemorrhage in rats

Cited by 22 publications

References 41 publications

Early constraint-induced movement therapy promotes functional recovery and neuronal plasticity in a subcortical hemorrhage model rat

Early constraint-induced movement therapy promotes functional recovery and neuronal plasticity in a subcortical hemorrhage model rat

Stroke Lesions in a Large Upper Limb Rehabilitation Trial Cohort Rarely Match Lesions in Common Preclinical Models

Motor Rehabilitation Provides Modest Functional Benefits After Intracerebral Hemorrhage: a Systematic Review and Meta-Analysis of Translational Rehabilitation Studies

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