Early onset <i>vs</i> late onset non‐psychotic, non‐melancholic unipolar depression

Benazzi, Franco

doi:10.1002/gps.1088

Cited by 9 publications

(6 citation statements)

References 7 publications

(5 reference statements)

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“…Nonetheless, it is meaningful to assess seasonality in early-onset, younger patients according to the given diagnosis at the time for the following reasons: to minimize seasonal mood symptoms and distress by taking preventable measures and to use seasonality as yet another feature of bipolarity in predicting polarity change. Second, early age at onset may be associated with clinical features different from later age at onset: more recurrences, atypical features, irritability, interpersonal sensitivity, and family history of mood disorders for MDD for instance (Benazzi, 2004). Such clinical characteristics may have impact on seasonality as a trait.…”

Section: Discussionmentioning

confidence: 99%

Bipolar II disorder has the highest prevalence of seasonal affective disorder in early‐onset mood disorders: Results from a prospective observational cohort study

Yeom

Cho

Jeon

et al. 2021

Depression and Anxiety

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Background: Many mood disorder patients experience seasonal changes in varying degrees. Studies on seasonality have shown that bipolar disorder has a higher prevalence rate in such patients; however, there is limited research on seasonality in early-onset mood disorder patients. This study estimated the prevalence of seasonality in early-onset mood disorder patients, and examined the association between seasonality and mood disorders. Methods: Early-onset mood disorder patients (n = 378; 138 major depressive disorder; 101 bipolar I disorder; 139 bipolar II disorder) of the Mood Disorder Cohort Research Consortium and healthy control subjects (n = 235) were assessed for seasonality with Seasonality Pattern Assessment Questionnaire (SPAQ).Results: A higher global seasonality score, an overall seasonal impairment score, and the prevalence of seasonal affective disorder (SAD) and subsyndromal SAD showed that mood disorder subjects had higher seasonality than the healthy subjects. The former subject group had a significantly higher mean overall seasonal impairment score than the healthy subjects (p < .001); in particular, bipolar II disorder subjects had the highest prevalence of SAD, and the diagnosis of bipolar II disorder had significantly higher odds ratios for SAD when compared to major depression and bipolar I disorder (p < .05).Conclusions: Early-onset mood disorders, especially bipolar II disorder, were associated with high seasonality. A thorough assessment of seasonality in early-onset mood disorders may be warranted for more personalized treatment and proactive prevention of mood episodes.

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Section: Discussionmentioning

confidence: 99%

Bipolar II disorder has the highest prevalence of seasonal affective disorder in early‐onset mood disorders: Results from a prospective observational cohort study

Yeom

Cho

Jeon

et al. 2021

Depression and Anxiety

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“…Firstly, determining the onset of the first depressive episode retrospectively is uncertain due to the time interval between age at onset and current age and there seems to be a substantial risk of recall bias. Secondly, since the participants with earlier onset are usually younger at entry into the studies [12, 29-31] and have a longer total length of illness and more depressive episodes [12], it becomes difficult to distinguish the effect of current age and different courses of illness from differences related to age-of-onset per se . Thirdly, there is no control of selection, when patients are included at some later point in the course of illness.…”

Section: Discussionmentioning

confidence: 99%

“…These studies have reported a higher prevalence of co-morbid PD [29, 30] and anxiety [29], a poorer response to treatment [29], more atypical features [31], higher levels of suicidal ideation [33], and more frequent family history of mood disorders [29, 31] among patients with early onset compared to later onset of depression. Further, the group of patients with onset of depression before the age of 25-35 years seems to be characterized by female gender [32, 33] and more severe and recurrent courses of illness [29, 31, 32]. However, all of the above-mentioned studies included pre-adult depressions in the early onset group, hence it is difficult to determine, how far the characteristics of this age group derived from patients with childhood or adolescent depression or from patients with early adult depression.…”

Section: Discussionmentioning

confidence: 99%

“…There is no consensus about the appropriate cut-off ages in previous studies assessing the impact of age-of-onset. In one study of 198 non-psychotic and non-melancholic outpatients [31], the median age at onset of the first depressive episode (29 years) was used to define early onset as compared to late onset depression. The clinical differences between the two groups (early onset depressions had significantly more recurrences, atypical features, irritability, interpersonal sensitivity and more frequently a family history of mood disorders) gradually disappeared as the age cut-off was increased to 40, 50 and 60 years, respectively, thereby providing some evidence for a cut-off age around 30 years.…”

Section: Introductionmentioning

confidence: 99%

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Differences Between Early and Late Onset Adult Depression

Bukh¹

2011

CPEMH

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Background:It is unclear, whether age-of-onset identifies subgroups of depression.Aim:To assess the clinical presentation of depression with onset in the early adult age (18-30 years) as compared to depression with later onset (31-70 years).Method:A total number of 301 patients with first episode depression were systematically recruited. Characteristics including psychiatric co-morbidity, personality disorders and traits, stressful life events prior to onset, family history, and treatment outcome were assessed by structured interviews and compared by chi-square tests for categorical data, t-tests for continuous parametric data and Mann-Whitney U-test for continuous nonparametric data. Logistic and multiple regression analyses were used to adjust the analyses for potentially confounding variables.Results:Patients with early onset of depression were characterised by a higher prevalence of co-morbid personality disorders, higher levels of neuroticism, and a lower prevalence of stressful life events preceding onset compared to patients with later age-of-onset. There were no differences in severity of the depressive episode, treatment outcome or family loading of psychiatric illness.Conclusion:Early adult onset of depression is associated with co-morbid personality deviances, whereas late onset is associated with environmental risk factors.

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“…Considering the role of different age onset in the pathology of MDD, we hypothesized that GMV abnormalities in different brain region might be observed respectively in early adult onset depression (EOD) and later adult onset depression (LOD), and these structural abnormalities might characterize EOD and LOD correspondingly. A previous study suggested that the median age at onset of MDD is 32 years ( Kessler et al, 2005 ), and the median age was often used as the cutoff point in mixed age samples ( Benazzi, 2004 ). To test our hypotheses, we defined the first episode of depression occurred before age 30 years as early adult onset depression which based on our previous study ( Cheng et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

Shen

Cheng

Yang

et al. 2016

NeuroImage: Clinical

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ObjectiveLittle is known about the pathological mechanism of early adult onset depression (EOD) and later adult onset depression (LOD). We seek to determine whether grey matter volume (GMV) change in EOD and LOD are different, which could also delineate EOD and LOD.MethodsIn present study, 147 first-episode, drug-naive patients with major depressive disorder (MDD), age between 18 and 45, were divided into two groups on the basis of age of MDD onset: the early adult onset group (age 18–29) and the later adult onset group (age 30–44), and a total of 130 gender-, and age-, matched healthy controls (HC) were also divided into two groups which fit for each patient group. Magnetic resonance imaging was conducted on all subjects. The voxel-based morphometry (VBM) approach was employed to analyze the images.ResultsWidespread abnormalities of GMV throughout parietal, temporal, limbic regions, occipital cortex and cerebellum were observed in MDD patients. Compare to young HC, reduced GMV in right fusiform gyrus, right middle temporal gyrus, vermis III and increased GMV in right middle occipital gyrus were seen in the EOD group. In contrast, relative to old HC, decreased GMV in the right hippocampus and increased GMV in the left middle temporal gyrus were observed in the LOD group. Compared to the LOD group, the EOD group had smaller GMV in right posterior cingulate cortex. There was no significant correlation between GMV of the right posterior cingulate cortex and the score of the depression rating scale in patients group.ConclusionsThe GMV of the brain areas that were related to mood regulation was decreased in the first-episode, drug-naive adult patients with MDD. Adult patients with EOD and LOD exhibited different GMV changes relative to each age-matched comparison group, suggesting depressed adult patients with different age-onset might have different pathological mechanism.

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Early onset vs late onset non‐psychotic, non‐melancholic unipolar depression

Cited by 9 publications

References 7 publications

Bipolar II disorder has the highest prevalence of seasonal affective disorder in early‐onset mood disorders: Results from a prospective observational cohort study

Bipolar II disorder has the highest prevalence of seasonal affective disorder in early‐onset mood disorders: Results from a prospective observational cohort study

Differences Between Early and Late Onset Adult Depression

Changes of grey matter volume in first-episode drug-naive adult major depressive disorder patients with different age-onset

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