Early-Onset Colorectal Cancer Survival among Unscreened Population -Multicenter Cohort Retrospective Analysis

Alsiary, Rawiah; Aboalola, Doaa; Alsolami, Mona; Alsaiari, Turki; Ramadan, Majed

doi:10.31557/apjcp.2023.24.4.1225

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Early onset CRC was identified in 23.26% of the population aged 18-50 years. Late-onset in the population older than 50 years appears to have a lower rate of survival and a greater likelihood of dying compared to the significantly higher survival rate of early onset [ 13 ]. In this retrospective study conducted in Riyadh, the efficacy of surveillance colonoscopies was evaluated.…”

Section: Recent Screening Projects In Saudi Arabiamentioning

confidence: 99%

Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update

Hassan Alqarni,

Alamri,

Pushparaj

et al. 2024

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Colorectal cancer (CRC) is the second most common cancer in the world. In Saudi Arabia, CRC is the most common cancer in males and the third most common in females, and its incidence rate is rising as the country continues to develop. However, the country does not have a national CRC screening program for CRC. This review aims to review recent studies that have attempted to address and rectify this issue and discern the most notable and prevalent barriers. Despite these efforts, guidelines are still lacking. Two prospective studies have been conducted in recent years, one of which was a national pilot screening program conducted by the Ministry of Health (MOH). While both had a similar number of participants, the colonoscopy rate for patients with a positive fecal immunochemical test (FIT) in the MOH program was only 20% compared to 75.8% in the Al-Kharj program. Awareness of the Saudi population regarding CRC and its screening appears to be insufficient. The most common barriers to patients' willingness to undergo screening were embarrassment, fear, and pain. Barriers to physicians are mostly related to factors outside their hands, such as lack of equipment and time. We conclude that efforts should be made to establish a national screening program and improve awareness of the population and physicians.

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Section: Recent Screening Projects In Saudi Arabiamentioning

confidence: 99%

Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update

Hassan Alqarni,

Alamri,

Pushparaj

et al. 2024

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Mortality‐to‐incidence ratio of early‐onset colorectal cancer in high‐income Asian and Middle Eastern countries: A systemic analysis of the Global Burden of Diseases Study 2019

Ramadan,

Alsiary,

Aboalola

2023

Cancer Medicine

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BackgroundThe incidence of early‐onset colorectal cancer (EO‐CRC) has been consistently rising leading to a significant cancer burden among younger adults in Asian and Middle Eastern high‐income countries. The study aims to investigate the survival outcomes of EO‐CRC among high‐income Asian and Middle Eastern populations from 1990 to 2019 using the mortality‐to‐incidence ratio, with a focus on examining the differences in gender.MethodsThis is a systematic analysis of the Global Burden of Disease (GBD) 2019 study. We include individuals aged 15 to 49 years old in high‐income Asian and the Middle Eastern countries. The colorectal cancer mortality‐to‐incidence ratio (MIR) was calculated for both genders by dividing the age‐specific mortality rate per 100,000 for colorectal cancer by the age‐specific incidence rate per 100,000 for each nation in the sample for a given year.ResultsAn overall decline in male and female MIR was observed from 1990 to 2019 in Asian and Middle Eastern countries. Ten out of thirteen Asian and Middle Eastern countries had a higher female MIR compared to their male counterparts. The global male MIR was found to be significantly higher than that of female (p‐value 0.008, coefficient estimate: 1.51). In Middle Eastern countries, Saudi Arabia had a significantly higher female MIR compared to their male counterparts (p < 0.0001, coefficient estimate: 12.65).ConclusionThis research addresses the knowledge gap concerning gender‐based differences in EO‐CRC survival outcomes in high‐income Asian and Middle Eastern countries, providing insights into the factors influencing these disparities in these regions. Policymakers should focus on developing targeted prevention and treatment programs for women, and addressing cultural and social barriers that may prevent women from seeking timely medical care.

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Five-Year Overall Survival of Early- and Late-Onset Colorectal Cancer in Medellín, Colombia: A Comparative Study

Ruiz-Grajales,

Correa-Cote,

Sánchez-Zapata

et al. 2024

Preprint

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Purpose Early-onset colorectal cancer (CRC) (EOCRC, < 50 years) has distinct clinicopathological features from late-onset CRC (LOCRC, ≥ 50 years). However, evidence on survival outcomes is contradictory. We aimed to analyse the differences in 5-year overall survival (OS) between EOCRC and LOCRC. Methods A retrospective cohort study was conducted during 2018–2022. Individuals aged ≥ 18 years diagnosed with CRC at two hospitals in Medellín, Colombia were included. Clinicopathological and survival data were retrieved from the medical records and a public government database. Patients were categorized into EOCRC and LOCRC groups. Five-year OS rates were calculated using the Kaplan-Meier method and prognostic factors for OS were identified through Cox regression models. Results Among 1022 patients, 52.5% were female, and 13.5% (n = 138) had EOCRC. EOCRC patients had higher 5-year OS rates than LOCRC patients (54% vs. 32%, Log-Rank, p = 0.001). Univariable analyses indicated a 37% lower risk of death for EOCRC compared to LOCRC (HR: 0.633, 95% CI: 0.476–0.840). After multivariable analyses, advanced staging and higher tumour grading were prognostic factors for worse OS (HR: 2.127, 95% CI: 1.405–3.220 and HR: 12.896, 95% CI: 6.310-26.355, respectively). Conversely, being in the EOCRC group remained as a prognostic factor for higher OS (HR: 0.482, 95% CI: 0.336–0.690). Conclusion EOCRC is associated with significantly better 5-year OS rates and prognosis compared to LOCRC. Advanced stage and higher tumour grading are predictors of lower OS among all CRC patients. These findings highlight the importance of age-related risk stratification and personalized therapeutic approaches in CRC.

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Early-Onset Colorectal Cancer Survival among Unscreened Population -Multicenter Cohort Retrospective Analysis

Cited by 3 publications

References 15 publications

Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update

Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update

Mortality‐to‐incidence ratio of early‐onset colorectal cancer in high‐income Asian and Middle Eastern countries: A systemic analysis of the Global Burden of Diseases Study 2019

Five-Year Overall Survival of Early- and Late-Onset Colorectal Cancer in Medellín, Colombia: A Comparative Study

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