Early-onset and late-onset group B streptococcal disease in Japan: a nationwide surveillance study, 2004–2010

Matsubara, Kousaku; Hoshina, Kiyoshi; Suzuki, Yoko

doi:10.1016/j.ijid.2012.11.027

Cited by 44 publications

(54 citation statements)

References 20 publications

(39 reference statements)

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“…In accordance with a previous study (Matsubara et al, 2013), our results show that genotype distribution differs by country and region. For example, Ia, II, III, and V are the main serotypes in Europe and the United States (Skoff et al, 2009;Tazi et al, 2011), while Ia and IV are dominant in Malaysia (Karunakaran et al, 2009).…”

Section: Discussionsupporting

confidence: 93%

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Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

et al. 2016

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ABSTRACT. With the advent of antibiotic resistance, pathogenic bacteria have become a major threat in cases of neonatal sepsis; however, guidelines for treatment have not yet been standardized. In this study, 15 cases of neonatal Streptococcus agalactiae sepsis from our hospital were retrospectively analyzed. Of these, nine cases showed early-onset and six cases showed late-onset sepsis. Pathogens were characterized by genotyping and antibiotic sensitivity tests on blood cultures. Results demonstrated that in cases with early-onset sepsis, clinical manifestations affected mainly the respiratory tract, while lateonset sepsis was accompanied by intracranial infection. Therefore, we suggest including a cerebrospinal fluid examination when diagnosing neonatal sepsis. Bacterial genotyping indicated the bacteria were mainly type Ib, Ia, and III S. agalactiae. We recommend treatment with penicillin or ampicillin, since bacteria were resistant to clindamycin and tetracycline. In conclusion, our results provide valuable information for the clinical treatment of S. agalactiae sepsis in neonatal infants.

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Section: Discussionsupporting

confidence: 93%

“…Patients with GBS-derived pneumonia were included, since GBS pneumonia was previously reported to be higher in developing countries (Matsubara et al, 2013). Considering the small sample size, further investigation is required to confirm our results.…”

Section: Discussionmentioning

confidence: 76%

Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

et al. 2016

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“…6 The rate of late-onset GBS diseases in Japan remained at 0.10 per 1,000 live births through 2004-2010, which was comparable to early-onset GBS diseases. 13 Our study found more lateonset GBS diseases (46.3%) than early-onset GBS diseases (21.9%). This may be explained by sampling bias as the study was conducted at only tertiary children's hospitals, which tend to admit neonates who need surgery rather than preterm or infants with severe illness who were discharged home after birth.…”

supporting

confidence: 42%

“…12 In Japan, the rates of early-onset GBS infections did not change before and after implementation of prevention guidelines at delivery in 2008, which were 0.08 per 1,000 live births in 2004-2008 and 0.10 per 1,000 live births in 2009-2010, respectively. 13,14 The Netherlands and Japan had much lower incidence of GBS diseases than the US, so those countries with low incidence of early-onset GBS diseases might not have benefited from prevention strategy.…”

mentioning

confidence: 99%

The microbiological characteristics of group B streptococcus at Japanese pediatric hospitals

Furuichi¹,

Goto²,

Tetsuka³

et al. 2016

RRN

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Group B streptococcus (GBS) is an important cause of serious bacterial infections (SBIs) in infants. Non-penicillin-susceptible GBS strains have been reported among adults, but little is known among children. We collected GBS isolates from 4 children's hospitals in Japan, and performed serotyping of GBS strains and reviewed penicillin minimum inhibitory concentrations of GBS strains from both sterile and non-sterile sites. Our examination revealed 235 isolates including 41 isolates from SBIs and 194 isolates from colonization. Nine cases of GBS SBIs (21.9%) were early-onset, 19 (46.3%) were late-onset, and 13 (31.7%) were ultralate-onset. Non-penicillin-susceptible GBS strains were not detected among either isolates. Serotypes Ia, Ib, and III were predominant among SBIs. In conclusion, at this time, we have no non-penicillin-susceptible GBS strains in Japanese children. Penicillin susceptibility should continue to be monitored carefully in each geographic area.

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“…20,21 A recent nationwide surveillance study in Japan has also shown that the estimated incidence of early-onset GBS disease was 0.08/1,000 live births. 22 The incidence of earlyonset GBS disease is apparently low in Japan, because the management of pregnant women with GBS based on the recommendations from the US Centers for Disease Control and Prevention (CDC) may have become standard and mostly followed in Japan. 23 Furthermore, no difference between each NICU was observed for the incidence of EOS in a study of Japanese NICUs.…”

Section: Recent Epidemiology Incidencementioning

confidence: 99%

Recent epidemiology of neonatal sepsis in Japan: did the strategies to control and prevent MRSA transmission lead to a reduction in the incidence of late-onset sepsis?

Morioka¹,

Iwatani²,

Koda³

et al. 2014

RRN

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Neonatal sepsis is a significant cause of morbidity and mortality in newborns, particularly in the preterm or low birth weight infant. In this epidemiologic review regarding neonatal sepsis, the recent epidemiology and causative pathogens in Japan are described and compared with data from international organizations. Recent Japanese multicenter studies report the incidence of neonatal sepsis at 0.74%. Although the incidence of early-onset sepsis has been low (0.13%), approximately 5% of very or extremely low birth weight infants develop late-onset sepsis with a high mortality rate. In Japan for such cases, the most predominant causative pathogen is methicillin-resistant Staphylococcus aureus; internationally, the most commonly reported pathogen is coagulase-negative staphylococci. It is our contention that the incorporation of the strategies to control and to prevent health care-associated MRSA transmission has contributed to the reduction in the incidence of late-onset sepsis.

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Early-onset and late-onset group B streptococcal disease in Japan: a nationwide surveillance study, 2004–2010

Abstract: The incidence of EOD and LOD is apparently low in Japan, but the mortality and morbidity rates remain substantial. The issue of national guidelines did not affect the incidence.

Cited by 44 publications

References 20 publications

Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis

The microbiological characteristics of group B streptococcus at Japanese pediatric hospitals

Recent epidemiology of neonatal sepsis in Japan: did the strategies to control and prevent MRSA transmission lead to a reduction in the incidence of late-onset sepsis?

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