Early OCT changes of neuroretinal foveal thickness after first versus repeated PDT in AMD

Landa, Gennady; Bukelman, Amir; Katz, Haya; Pollack, Ayala

doi:10.1007/s10792-007-9176-0

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…7-10 However, frequent persistence and recurrence of CNV, which require multiple treatments and are associated with poor long-term visual outcomes, are major limitations. 34,35 Recent studies have demonstrated that PDT causes selective photothrombosis but it also produces inflammatory effects with delivery of local proangiogenic factors. Upregulation of VEGF may explain the high recurrence rate of CNV (nearly 98%) within 3 months following PDT.…”

Section: Commentmentioning

confidence: 99%

Combination of Photodynamic Therapy and Intraocular Triamcinolone for Exudative Age-Related Macular Degeneration and Long-Term Chorioretinal Macular Atrophy

et al. 2008

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Objective: To evaluate the long-term effect of intravitreal triamcinolone acetonide (IVT) treatment combined with photodynamic therapy (PDT) vs PDT alone for neovascular age-related macular degeneration.Methods: Prospective randomized study. Eighty-four patients were enrolled to receive PDT (n=41) or IVT treatment followed by PDT (n=43) within approximately a 7-to 15day interval. All patients were naive to treatment. At baseline and each follow-up visit at 3, 6, 12, and 24 months, measurement of best-corrected visual acuity (VA), fluorescein angiography, indocyanine green angiography, and optical coherence tomography were performed. Mean changes in VA and retreatment rate were considered as primary outcomeindicators.Analysisofvascularchoroidalchangesdocumented by indocyanine green angiography and fundus autofluorescence measurements were also performed. Results:Mean VA increased at 1 month of follow-up but decreased progressively by the 24-month point in both groups (P=.74). The retreatment rate was significantly lower (P Ͻ .001) in the combined therapy group. Choroidal hypoperfusion/nonperfusion (PϽ.001) and areas with decreased/absent fundus autofluorescence within the PDT spot area were significantly greater with combined therapy (PϽ .001). Conclusions:Combination IVT treatment with PDT seemed to be more effective for managing neovascular age-related macular degeneration, but long-term analysis failed to demonstrate functional benefits.

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Section: Commentmentioning

confidence: 99%