Early neurophysiology and MRI in predicting neurological outcome at 9–10years after birth asphyxia

Kontio, T.; Toet, Mona C.; Hellström‐Westas, Lena; Handel, M; Groenendaal, Floris; Stjerna, Susanna; Vanhatalo, Sampsa; Vries, Linda S. de

doi:10.1016/j.clinph.2012.12.045

Cited by 19 publications

(21 citation statements)

References 37 publications

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“…19, 27, 28 Similarly, later follow-up of infants with mild NE at school age has demonstrated that 50% of these children have abnormalities on MRI at nine to ten years of age. 29 Further, they have lower IQ scores and increased thought problems compared with healthy controls. 12 Although our data exclusively focused on neonatal MRI outcomes, these results support our findings of increased neurological risk in mild NE.…”

Section: Discussionmentioning

confidence: 99%

The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy

Walsh

Neil

Morey

et al. 2017

The Journal of Pediatrics

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Objective To assess and contrast the incidence and severity of abnormalities on cerebral magnetic resonance imaging (MRI) between infants with mild, moderate, and severe neonatal encephalopathy who received therapeutic hypothermia. Study design This is a retrospective cohort study of infants with mild, moderate, and severe NE who received TH at a single tertiary neonatal intensive care unit (NICU) between 2013 and 2015. Two neuro-radiologists masked to the clinical condition evaluated brain MRIs for cerebral injury following TH using the Barkovich classification system. Additional abnormalities not included in this classification system were also noted. The rate, pattern, and severity of abnormalities/injury were compared across the grades of NE. Results Eighty-nine infants received TH and met study criteria – 48 with mild NE, 35 with moderate NE, and six with severe NE. Forty-eight infants (54%) had an abnormality on MRI. There was no difference in the rate of overall MRI abnormalities by grade of NE (mild NE 54%, moderate NE 54%, and severe NE 50%, p=0.89). Basal ganglia/thalamic injury was more common in those with severe NE (mild NE 4%; moderate NE 9%; severe NE 34%, p=0.03). In contrast, watershed injury did not differ between NE grades (mild NE 36%; moderate NE 32%; severe NE 50%, p=0.3) Conclusion Mild NE is commonly associated with MRI abnormalities after TH. The grade of NE during the first hours of life may not adequately discriminate between infants with and without cerebral injury noted by MRI after TH.

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Section: Discussionmentioning

confidence: 99%

The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy

Walsh

Neil

Morey

et al. 2017

The Journal of Pediatrics

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“…It has also been suggested that a combination of multiple techniques, such as aEEG, VEEG, VEPs, and SEPs can synergistically improve the prognosis of long‐term neurological outcome in comparison with single modalities . Amantini et al hypothesize that multimodal neurophysiological monitoring (MNM) would be useful in evaluating brain activity in neonates as well as in adults…”

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confidence: 99%

Multimodal neurophysiological monitoring in healthy infants born at term: normative continuous somatosensory evoked potentials data

Lori

Gabbanini

Bastianelli

et al. 2017

Develop Med Child Neuro

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“…Increased seizure burden assessed by full-array EEG monitoring has been linked with more severe patterns of brain injury on MRI and overall degree of encephalopathy 14. Similarly, data from neonates with hypoxic ischaemic encephalopathy who did not receive hypothermia has also shown that presence of seizures on aEEG is associated with worse outcomes 15. While the CoolCap study also showed presence of seizures on aEEG was associated with poor outcome, further research is needed to explore this relationship 9…”

Section: Indications and Limitations (What Is Aeeg Used For?)mentioning

confidence: 99%

How to use: amplitude-integrated EEG (aEEG)

Shah

Wusthoff

2014

Arch Dis Child Educ Pract Ed

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Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of brain activity that is increasingly used in the neonatal intensive care unit. In its simplest form, aEEG is a processed single-channel electroencephalogram that is filtered and time-compressed. Current evidence demonstrates that aEEG is useful to monitor cerebral background activity, diagnose and treat seizures and predict neurodevelopmental outcomes for preterm and term infants. This review aims to explain the fundamentals behind aEEG and its clinical applications.

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Early neurophysiology and MRI in predicting neurological outcome at 9–10years after birth asphyxia

Cited by 19 publications

References 37 publications

The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy

The Frequency and Severity of Magnetic Resonance Imaging Abnormalities in Infants with Mild Neonatal Encephalopathy

Multimodal neurophysiological monitoring in healthy infants born at term: normative continuous somatosensory evoked potentials data

How to use: amplitude-integrated EEG (aEEG)

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