Early neural activation for lexico-semantic access in the left anterior temporal area analyzed by an fMRI-assisted MEG multidipole method

Fujimaki, Norio; Hayakawa, Tomoe; Ihara, Atsushi; Wei, Qiang; Munetsuna, Shinji; Terazono, Yasushi; Matani, Ayumu; Matsumoto, Tsutomu

doi:10.1016/j.neuroimage.2008.10.021

Cited by 27 publications

(26 citation statements)

References 57 publications

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“…In the present study, the anterior part of the inferior temporal lobe was subsequently activated for both tasks, from 240 to 280 ms, in agreement with similar results provided by an MEG study (Fujimaki et al, 2009). However, our results revealed longer involvement of the activation of the anterior part of inferior temporal lobe for semantic compared with phonological task.…”

Section: Spatiotemporal Integration Of Phonological and Semantic Procsupporting

confidence: 93%

“…However, our results revealed longer involvement of the activation of the anterior part of inferior temporal lobe for semantic compared with phonological task. This result confirms the crucial role of this region for the semantic access (Mummery et al, 2000;Marinkovic et al, 2003;Bright et al, 2004;Gorno-Tempini et al, 2004;Noppeney et al, 2007;Fujimaki et al, 2009;Lambon Ralph et al, 2009;Binney et al, 2010;Visser et al, 2010). This region could serve as a hub within the widespread semantic system.…”

Section: Spatiotemporal Integration Of Phonological and Semantic Procsupporting

confidence: 80%

“…Semantic processing also involves the anterior temporal lobe (Fujimaki et al, 2009;Binney et al, 2010;Visser et al, 2010), which might convert modality-specific information into amodal representations to extract all semantic attributes (Marinkovic et al, 2003;Patterson et al, 2007;Lau et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

Yvert

Perrone‐Bertolotti²,

Baciu³

et al. 2012

J. Neurosci.

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Integration of phonological and lexicosemantic processes is essential for visual word recognition. Here we used dynamic causal modeling of event-related potentials, combined with group source reconstruction, to estimate how those processes translate into context-dependent modulation of effective connectivity within the temporal-frontal language network. Fifteen healthy human subjects performed a phoneme detection task in pseudo-words and a semantic categorization task in words. Cortical current densities revealed the sequential activation of temporal regions, from the occipital-temporal junction toward the anterior temporal lobe, before reaching the inferior frontal gyrus. A difference of activation between phonology and semantics was identified in the anterior temporal lobe within the 240 -300 ms peristimulus time window. Dynamic causal modeling indicated this increase of activation of the anterior temporal lobe in the semantic condition as a consequence of an increaseofforwardconnectivityfromtheposteriorinferiortemporallobetotheanteriortemporallobe.Inaddition,fastactivationoftheinferior frontal region, which allowed a feedback control of frontal regions on the superior temporal and posterior inferior temporal cortices, was found to be likely. Our results precisely describe spatiotemporal network mechanisms occurring during integration of phonological and semantic processes. In particular, they support the hypothesis of multiple pathways within the temporal lobe for language processing, where frontal regions would exert a top-down control on temporal regions in the recruitment of the anterior temporal lobe for semantic processing.

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Section: Spatiotemporal Integration Of Phonological and Semantic Procsupporting

confidence: 93%

Section: Spatiotemporal Integration Of Phonological and Semantic Procsupporting

confidence: 80%

See 1 more Smart Citation

Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

Yvert

Perrone‐Bertolotti²,

Baciu³

et al. 2012

J. Neurosci.

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show abstract

“…Using pronounceable pseudoword foils, Hauk, Davis, Ford, Pulvermüller, and Marslen-Wilson (2006) found evidence of orthographic influences at 100 ms after stimulus onset, followed rapidly by semantic coherence effects at 160 ms. Similarly, using MEG and fMRI recording during lexical decision with pronounceable katakana pseudoword foils, Fujimaki et al (2009) found evidence of orthographic processing in ventral occipital-temporal regions at 100-150 ms after stimulus onset, soon followed by evidence of semantic processing at 200 ms within the left anterior temporal area, which activated concurrently with phonological processing in left posterior superior temporal regions.…”

Section: Discussionmentioning

confidence: 89%

What’s in a word? A parametric study of semantic influences on visual word recognition

2012

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To what extent does semantic information play a functional role in visual word recognition? Theories of word recognition vary in the importance assigned to semantic information in visual lexical decision, with past research suggesting that the nature of the foils is a crucial determinant of semantic reliance. Here, we explored the conditions under which semantic variables influence lexical decision. Normal readers performed visual lexical decision tasks in which imageability and semantic priming were manipulated, with nonword foils varying systematically in their orthographic and phonological similarity to the real words. The effects of imageability and semantic priming increased in magnitude as nonword foils became progressively more wordlike. These findings provide a clear illustration of the flexible use of semantic information to support normal visual word recognition.

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“…Both regions have also been implicated in non-combinatorial, lexical-level tasks as well, such as lexical decision (Nobre et al, 1994;Mummery et al, 1999;Fujimaki et al, 2009), repetition detection (Halgren et al, 1994), and semantic relatedness judgments (Vandenberghe et al, 1996). Additionally, both regions exhibit classical lexical-level effects, such as decreased activity for more frequent (Halgren et al, 2002) or primed (Mummery et al, 1999;Dale et al, 2000;Dhond et al, 2001;Marinkovic et al, 2003) words.…”

Section: Atl and Vmpfc Effects Of Compositionmentioning

confidence: 99%

Simple Composition: A Magnetoencephalography Investigation into the Comprehension of Minimal Linguistic Phrases

2011

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The expressive power of language lies in its ability to construct an infinite array of ideas out of a finite set of pieces. Surprisingly, few neurolinguistic investigations probe the basic processes that constitute the foundation of this ability, choosing instead to focus on relatively complex combinatorial operations. Contrastingly, in the present work, we investigate the neural circuits underlying simple linguistic composition, such as required by the minimal phrase "red boat." Using magnetoencephalography, we examined activity in humans generated at the visual presentation of target nouns, such as "boat," and varied the combinatorial operations induced by its surrounding context. Nouns in minimal compositional contexts ("red boat") were compared with those appearing in matched noncompositional contexts, such as after an unpronounceable consonant string ("xkq boat") or within a list ("cup, boat"). Source analysis did not implicate traditional language areas (inferior frontal gyrus, posterior temporal regions) in such basic composition. Instead, we found increased combinatorial-related activity in the left anterior temporal lobe (LATL) and ventromedial prefrontal cortex (vmPFC). These regions have been linked previously to syntactic (LATL) and semantic (vmPFC) combinatorial processing in more complex linguistic contexts. Thus, we suggest that these regions play a role in basic syntactic and semantic composition, respectively. Importantly, the temporal ordering of the effects, in which LATL activity (ϳ225 ms) precedes vmPFC activity (ϳ400 ms), is consistent with many processing models that posit syntactic composition before semantic composition during the construction of linguistic representations.

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Early neural activation for lexico-semantic access in the left anterior temporal area analyzed by an fMRI-assisted MEG multidipole method

Cited by 27 publications

References 57 publications

Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

Dynamic Causal Modeling of Spatiotemporal Integration of Phonological and Semantic Processes: An Electroencephalographic Study

What’s in a word? A parametric study of semantic influences on visual word recognition

Simple Composition: A Magnetoencephalography Investigation into the Comprehension of Minimal Linguistic Phrases

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