Early myositis ossificans progressiva occurring in homozygotic twins

The syndrome of myosclerosis

“…The interesting conditions of focal proliferative myositis (Kern, 1960;Enzinger and Dulcey, 1967;MacKenzie, 1970) and fasciitis (MacKenzie, 1970) usually present as a rapidly growing tumour often thought to be a sarcoma before biopsy. Myositis ossificans initially may present with simple fibrosis of muscle (Eaton, Conkling, and Daeschner, 1957), rather than the classical features of painful swellings of muscles which rapidly ossify causing deformity, often with associated intermittent fever (Mair, 1932;McKusick, 1966). Skeletal muscle is not involved in either plantar or palmar fibromatosis but is the characteristic site of development of desmoid fibromatosis (Shuman, 1971).…”

Myositis Ossificans Progressiva::Clinical and Metabolical Observations in a Case Treated with a Diphosphonate (EHDP) and Surgical Removal of Ectopic Bone

“…Many therapeutic regimens have been tried and advocated including cortisone (Eaton et al 1957), ACTH (Dixon et al 1954) or measures to prevent mineralization, such as the use of calcium chelating agents or dietary restriction of calcium (Davis & Moe 1959). None have, however, been effective until the recent use of diphosphonate in several 000 1 ~ 6470/79/0 1003 3 -06)OZ.…”

Myositis Ossificans Progressiva (Munchmeyer's Disease): Brief review with report of two cases treated with corticosteroids and observed for 16 years

“…There have been cases in homozygotic twins (Eaton, Conkling, and Daeschner, 1957;Vastine, Vastine, and Arango, 1948), and many examples of two or more in a family, including 5 males in 3 generations (quoted by McKusick, 1960), or of an affected child, with nothing more than the abnormal hallux in the father. The hereditary aspect was reviewed by Tunte, Becker, and Knorre (1967).…”