Early mucinous colorectal adenocarcinoma – mucosal type

Wolf, Eugene M.; Watanabe, Hikaru; Spuller, Ekkehard; Leskowschek, H.; Langner, C.

doi:10.1055/s-0030-1255571

Cited by 1 publication

(1 citation statement)

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“…The mucinous colorectal adenocarcinoma-mucosal type, which was endoscopically resected in this case, was first reported in 2010[ 22 ]. To date, no other mucinous adenocarcinoma treated endoscopically has been reported in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma: A case report

Murakami¹,

Tanabe²,

Ono³

et al. 2023

World J Gastrointest Oncol

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BACKGROUND Mucinous adenocarcinoma of the colorectum is a rare histological subtype characterized by an abundant mucinous component. Mucinous tumors are frequently diagnosed at an advanced stage, which indicates an aggressive subtype. However, few case reports have been published, and little information is available concerning genetic alterations in mucinous adenocarcinoma. CASE SUMMARY A 76-year-old man underwent en bloc endoscopic submucosal dissection (ESD) for the management of a type 0-Is+IIa lesion. Histological examination revealed an intramucosal mucinous adenocarcinoma with signet-ring cell carcinoma and well-to-moderately differentiated tubular adenocarcinoma. Three years after the ESD, local recurrence was detected by an endoscopic examination, revealing a new 0-Is+IIa lesion with a phenotype similar to the previously resected lesion. Re-ESD was chosen for the management of the recurrent tumor, and the histological examination showed positive tumor infiltration at the vertical margin. Additional surgical resection was performed for the curative treatment. Genetic analysis showed pathogenic alterations in RNF43 and TP53 in the adenoma and an additional SMAD4 alteration in the carcinoma. CONCLUSION This mucinous mucosal adenocarcinoma case was suggested to have an aggressive phenotype and a careful and close follow-up are required.

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Section: Discussionmentioning

confidence: 99%