Early Mortality and Morbidity in Infants with Birth Weight of 500 Grams or Less in Japan

Inoue, Hirosuke; Ochiai, Masayuki; Yasuoka, Kazuaki; Tanaka, Kōichi; Kurata, Hiroaki; Fujiyoshi, Junko; Matsushita, Yuki; Suga, Shutaro; Nonaka, Kenichi; Taguchi, Tomoaki; Kato, Kiyoko; Ohga, Shouichi

doi:10.1016/j.jpeds.2017.05.017

Cited by 44 publications

(55 citation statements)

References 36 publications

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“…It is possible some of these differences could be due to differences in attitudes towards resuscitation . Certainly in cohorts where a more liberal approach to resuscitating babies ≤500 g are used, higher survival rates have been reported .…”

Section: Discussionmentioning

confidence: 99%

Outcomes of infants with a birthweight less than or equal to 500 g in Northern England: 15 years experience

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Outcomes of infants with a birthweight less than or equal to 500 g in Northern England: 15 years experience

et al. 2017

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“… However, the use of tcPCO 2 monitoring decreased the frequency of blood gas samplings among ventilated neonates without affecting the duration of mechanical ventilation or clinical outcome . The Neonatal Research Network in Japan, has reported the progress in survival and neurodevelopmental outcome of the infants born at the “limit of viability” . Transcutaneous blood gas monitoring was expected to be useful (30.4%) in future neonatal medical care in Japan.…”

Section: Discussionmentioning

confidence: 99%

“…Advances in perinatal–neonatal medicine have greatly improved the survival rate of infants born during the pre‐viable period, or at extremely‐low birthweight . A variety of treatment modalities have been introduced with regard to the concept of minimal handling in neonatal intensive care unit (NICU).…”

mentioning

confidence: 99%

Transcutaneous blood gas monitoring among neonatal intensive care units in Japan

Ochiai

Kurata

Inoue

et al. 2020

Pediatrics International

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Background This study aimed to investigate the utility of transcutaneous (tc) measurements of partial pressure of oxygen (tcPO2) and carbon dioxide (tcPCO2) monitoring in neonatal intensive care units (NICUs) in Japan. Methods At the end of 2016,we sent a survey questionnaire on tc monitoring to all 106 NICUs registered with the Japanese Neonatologist Association. The questions included usage, subjects, methods, management, and the practical usefulness of tc monitoring. Results The questionnaire was returned by 69 NICUs (65.1% of response rate). Seventeen institutions (24.6%) measured both tcPCO2 and tcPO2, and 42 (60.9%) measured tcPCO2 alone. Transcutaneous PCO2 or tcPO2 monitoring was applied for “pre‐viable” infants born at 22–23 weeks’ gestational age (18.6% vs 23.5%), and infants of <500 g birthweight (30.5% vs 17.6%). The tcPCO2 and tcPO2 monitoring was started at birth in 49.2% and 70.6% of the newborn infants, respectively. The temperature of the sensor was set at <38°C for tcPCO2 in 54.3% and >42°C for tcPO2 in 58.9% of NICUs. The accuracy for tcPO2 was rated as good in 35.3% or moderate in 64.7%, of institutions but or for tcPCO2 as 1.7% or 93.2%of institutions , respectively. Conclusion Transcutaneous monitoring was widely, but limitedly, used for preterm infants. The lower temperature of the tcPCO2 sensor compared to that reported in other developed countries might compromise the accuracy but increase the feasibility of tc monitoring in Japan.

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“…The use of such a tool is not always justified, since survival by period is subject to the class of exponential distributions, and in this case it is advisable to use survival analysis regressions, such as the Cox models. The Cox proportional hazards models are used to assess the survival of hypotrophic babies (Inoue, Ochiai and Yasuoka, 2017).…”

Section: Methodsmentioning

confidence: 99%

Statistical Models of Economic Burden: A Case Study in Medicine

Лакман¹,

Maksimenko²,

R.Kh.³

et al. 2019

IJEBA

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Purpose: The main aim of this article is to use statistical methods for the estimation of the economic burden and the survival rate of deeply premature babies. Design/Methodology/Approach: The results of a survey of 2.222 children with a birth weight of 501-1500 grams and a gestational age of 23-37 weeks were used as input data. Cox's proportional hazards model was used as a survival tool. Findings: The results of Cox survival regression model showed a series of statistically significant predictors of survivability (p<0.05) for three age cohorts: neonatal, postnatal and pediatric (until 2 years). One of the statistically significantly predictors of survivability of premature infants with very low birth weight (VLBW) and extremely low birth weight (ELBW) in every age cohort is the volume of primary resuscitation measure and the length of stay in the neonatal pathology unit (NPU). Practical Implications: The results permitted to assess the amount of nursing care measures, the duration of care in a neonatal pathology unit, the rehabilitation of children with VLBW and ELBW in the long run. The assessment will ultimately help to estimate the overall economic burden associated with maintaining health and quality of life of premature babies. Originality/Value: The scientific contribution of the study consists in the use of an integrated approach to the problem of estimating the economic burden of nursing very premature babies, taking into account their survival and subsequent disability risks in the neonatal, postnatal, and pediatric periods.

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Early Mortality and Morbidity in Infants with Birth Weight of 500 Grams or Less in Japan

Abstract: Improvements in perinatal-neonatal medicine have improved the survival, but not the rate of major morbidities, of infants with a BW ≤500 g in Japan.

Cited by 44 publications

References 36 publications

Outcomes of infants with a birthweight less than or equal to 500 g in Northern England: 15 years experience

Outcomes of infants with a birthweight less than or equal to 500 g in Northern England: 15 years experience

Transcutaneous blood gas monitoring among neonatal intensive care units in Japan

Statistical Models of Economic Burden: A Case Study in Medicine

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