Early Morphea Simulating Patch-Stage Mycosis Fungoides

Fujimoto, Masakazu; Basko-Plluska, Juliana; Petronic‐Rosic, Vesna; Shea, Christopher R.

doi:10.1097/dad.0000000000000271

Cited by 11 publications

(21 citation statements)

References 11 publications

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“…4,6 Early active morphea with indistinct sclerosis sometimes clinically and histopathologically simulates other inflammatory dermatoses such as mycosis fungoides. 8 In the present study, patient two presented 2 months after disease onset, and she was diagnosed with early active morphea based on the clinical manifestation of a 'lilac ring' and histopathological lymphocytic perivascular infiltration. Conversely, patient one visited our site 1 year after presentation, and the histopathological findings mainly included thickened and homogenized collagen bundles at the dermis and atrophic appendages.…”

Section: Discussionmentioning

confidence: 69%

Small-sized shiny sclerotic plaques: Think early morphea

Hashimoto

Nakahara

2022

Eur J Inflamm

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Morphea is a rare fibrosing disorder of the skin and underlying tissues. To date, the size of morphea has not been adequately discussed. Here, we report two cases of small-sized superficial circumscribed morphea. Both cases clinically revealed single circumscribed, round to oval area of shiny sclerotic plaque at distal extremities. There are several options for the treatment of superficial circumscribed morphea, such as topical corticosteroid and phototherapy. The early recognition of small-sized morphea enables appropriate diagnosis and follow-up, leading to improve disease prognosis.

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Section: Discussionmentioning

confidence: 69%

Small-sized shiny sclerotic plaques: Think early morphea

Hashimoto

Nakahara

2022

Eur J Inflamm

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“… 8 In one report, authors considered the possibility of coexisting MF and morphea and recommended that early morphea should be added to the list of cutaneous T-cell lymphomas. 9 Coexistence of patch-stage MF and interstitial granuloma annulare has also been described. 10 , 11 In addition, systemic sclerosis has also been associated with MF.…”

Section: Discussionmentioning

confidence: 99%

Early morphea simulating patch-stage mycosis fungoides in two cases

et al. 2018

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Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea mimicking patchstage of MF. Histopathologic examination of biopsies obtained early in the disease course revealed lymphocytic epidermotropism arranged in small pautrier-like collections as well as linear arrangements in dermal- epidermal junction. Additional biopsies were performed which revealed replacement of subcutaneous fat with closely packed thick collagen bundles under eccrine glands. This report points toward the fact that early stage morphea can simulate MF. Therefore additional evaluation is sometimes required for definite diagnosis.

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“…This was confirmed by other studies that researched the overlapping histopathologic features of MF and psoriasis (Doukaki et al, 2009, Jinno et al, 2015), lichen (Citarella et al, 2003, Magro et al, 1997, Suchak et al, 2010), eczema (Ackerman et al, 1974, Ecker and Winkelmann, 1981, LeBoit and Epstein, 1990, Miyagaki and Sugaya, 2011, Orbaneja et al, 1976, Reddy and Bhawan, 2007, Solomon et al, 2016, White, 1990), pseudolymphoma (Choi et al, 2003, Rijlaarsdam et al, 1991, Rijlaarsdam et al, 1992), cutaneous drug reactions (Sarantopoulos et al, 2013), parapsoriasis (Goldberg, 2012), chronic and nonspecific dermatitis (Elmer and George, 1999), and others dermatosis (Deen et al, 2015, Fujimoto et al, 2015, Kazlouskaya et al, 2015, Lim et al, 2015, Rodriguez-Acosta et al, 2013, Yalcin et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Defining the mimics and clinico-histological diagnosis criteria for mycosis fungoides to minimize misdiagnosis

Kelati

Gallouj

Tahiri

et al. 2017

International Journal of Women's Dermatology

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BackgroundMycosis fungoides (MF) is a significant diagnostic challenge; it has various differential diagnosis especially at an early stage. Our aim was to describe mimics of MF clinically and histologically, and to define significant diagnostic criteria of the disease.MethodsThis was a retro-prospective cohort of 370 patients in whom the diagnosis of MF was suspected clinically.ResultsMF was histologically confirmed in 15.4% of cases and rejected in 84.5%. Other identified histologically diagnosis were eczema, psoriasis; nonspecific dermatitis, lichen, lupus; pseudolymphoma, parapsoriasis and toxidermia. 4 patients with palmoplantar MF were wrongly treated as eczema, and 10 patients with psoriasiform MF were initially treated as psoriasis. We also described the clinical, histological and immunohistochemistry diagnostic criteria for distinguishing MF from benign dermatosis.ConclusionsMisdiagnosis of MF was a real problem for this study, because it shared common clinical and histological characteristics with other inflammatory diseases like eczema and psoriasis. Therefore, defining significant clinico-histological diagnosis criteria of MF would be of great help and would increase the accuracy of the diagnosis.

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Early Morphea Simulating Patch-Stage Mycosis Fungoides

Cited by 11 publications

References 11 publications

Small-sized shiny sclerotic plaques: Think early morphea

Small-sized shiny sclerotic plaques: Think early morphea

Early morphea simulating patch-stage mycosis fungoides in two cases

Defining the mimics and clinico-histological diagnosis criteria for mycosis fungoides to minimize misdiagnosis

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