Early molecular responses of mangrove oysters to nanoplastics using a microfluidic device to mimic environmental exposure

Origin, exposure routes and xenobiotics impart nanoplastics with toxicity on freshwater bivalves

“…This could underline a disturbance of the energetic balance leading to an oxidative stress in clams after NP-L entry. Similar trends were observed in previous studies on the pacific oyster I. alatus exposed through the direct route to NPs, with the up-regulation of cav, 12S and cat genes 33 , whereas it was not observed after dietary exposure 15 . Surprisingly, no response was observed towards apoptosis in gills, with a global inhibition of gadd45, p53 and bax in all conditions tested (except Al).…”

“…Unlike in gills, we observed in the visceral mass a very strong increase of 12s expression in all conditions tested. Such up-regulations have been reported in other studies on the oyster I. alatus after a direct exposure to environmental NPs for one week 31, 33 . This may show a trial to increase mitochondria number that could be at least partly related to the increase in energy demand to excrete NPs.…”

“…The expression of cox1 in gills of Isognomon alatus was not modulated after neither water- nor diet borne exposures to environmental NPs for 7 days 15 , 31 . However, the expression of 12s was up-regulated in gills of I. alatus after direct exposure to environmental NPs 31, 33 while it was down-regulated in the present study. Overall, similar studies conducted so far under saline conditions showed effects following a reverse dose-response relationship 33 whereas in the present study the gene modulation was dose-dependent.…”

“…We also observed an increase of the expressions of genes involved in immunity, oxidative stress and apoptosis in visceral mass ( atg12, sod1, sod2 and cat ). This led to an apoptotic response in the Diet NP-L condition only, with the up-regulation of p53 , as shown on the pacific oyster I. alatus 33 .…”

Post-Global Pandemic Challenges and improvements in advanced detection and removal processes of toxic pollutants: Editorial

“…This Special issue shows studies related to copper ( Belbachir et al, 2022 , Stala et al, 2022 ), mercury ( Windisch et al, 2022 ), arsenic ( Jakukowicz-Sobala et al, 2022 ; Zaric et al, 2022 ; Carneiro et al, 2022 ), selenium (Parra-Martinez et al, 2022; Arias - Borrego et al, 2022 ), and other heavy and radioactive metals ( Irfan et al, 2022 ; Zheng et al, 2022; Germande et al, 2022 ; Krawczy-Barsch et al, 2022) detection and speciation, organic matter and inorganic ions removal ( Pidoux et al,. 2022 ), quantitative analysis of metabolites ( Wang et al, 2022 ), estrogens ( Zdarta et al, 2022 ), uses and detection of nanomaterials ( Kuo et al, 2022 , Saravanakumar et al, 2022 ), nanoplastics ( Arini et al, 2022 ), HCH derivatives ( Alvarez et al, 2022 ), antibiotics ( Zaheer Afzal et al, 2022 ), pesticides ( Jevremovic et al, 2022 ), photodegration processes ( Kumar et al, 2022 ), cell internalization drugs ( Ahmadi et al, 2022 ), dyes and pigments degradation ( Jankowska et al, 2022 ), and bacteria studies ( Arruda et al, 2022 , Xiang et al, 2022 ) in a very long different group of samples, including fresh environmental water, seawater, wastewater, different soils, food, marine organism, bacteria, mice’s, etc.…”