Early Modification in Drainage of Interleukin-1β and Tumor Necrosis Factor-α Best Predicts Surgical-Site Infection After Cervical Neck Dissection for Oral Cancer

Candau-Alvarez, Alberto; Gil-Campos, Mercedes; Torre-Aguilar, María José de la; Llorente-Cantarero, Francisco J.; López‐Miranda, José; Pérez-Navero, Juan Luís

doi:10.1016/j.joms.2014.12.023

Cited by 12 publications

(13 citation statements)

References 44 publications

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“…In this study, we come to the finding that tracheostomy lead to the increase of sputum viscosity, activation of TNF-α and AQP4, disorder of trachea mucosa and cilia, as expected, saline nebulization might provide a beneficial effect on reducing the sputum viscosity, decreasing the TNF-α and AQP4 expression, promoting the function of trachea mucosa and cilia, our results are consistent with previous studies [21–24]. Besides, the efficacy of saline nebulization with different osmolality after tracheostomy might be different.…”

Section: Discussionsupporting

confidence: 92%

“…The early modification of interleukin-1 and TNF-α in the drainages may best predict surgical-site infection [21]. The results from Goldman’ study [27] suggested that TNF-α might mediate the acid aspiration-induced local and systemic injury, specifically the systemic leukosequestration and permeability following localized aspiration was mediated by TNF-α induced synthesis of an adhesion protein, and the tracheostomy might promote the up-regulation of neutrophil endothelial adhesion receptors.…”

Section: Discussionmentioning

confidence: 99%

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The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

Wen

Cui

et al. 2016

BMC Pulm Med

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BackgroundSaline fluid nebulization is highly recommend to combat the complications following tracheostomy, yet the understandings on the role of osmolality in saline solution for nebulization remain unclear.ObjectivesTo investigate the biological changes in the early stage after tracheostomy, to verify the efficacy of saline fluid nebulization and explore the potential role of osmolality of saline nebulization after tracheostomy.MethodsSprague-Dawley rats undergone tracheostomy were taken for study model, the sputum viscosity was detected by rotational viscometer, the expressions of TNF-α, AQP4 in bronchoalveolar lavage fluid were assessed by western blot analysis, and the histological changes in endothelium were evaluated by HE staining and scanning electron microscopy (SEM).ResultsStudy results revealed that tracheostomy gave rise to the increase of sputum viscosity, TNF-α and AQP4 expression, mucosa and cilia damage, yet the saline fluid nebulization could significantly decrease the changes of those indicators, besides, the hypertonic, isotonic and hypertonic saline nebulization produced different efficacy.ConclusionsOsmolality plays an important role in the saline fluid nebulization after tracheostomy, and 3% saline fluid nebulization seems to be more beneficial, further studies on the role of osmolality in saline fluid nebulization are warranted.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

Wen

Cui

et al. 2016

BMC Pulm Med

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“…In a recent study, it was found that early collection of wound fluids and analysis of IL-1β and TNF-α could predict clinical outcome regarding SSIs after neck dissection surgery (33), further illustrating the potential of using cytokines such as IL-1β and TNF-α as specific biomarkers for wound healing. The method used here, based on extraction of tie-over dressings to obtain wound fluid material, proved to be a simple and painless way to examine wound biomarkers, which could potentially act as “reporters” for wound healing outcome and SSIs.…”

Section: Discussionmentioning

confidence: 99%

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting

et al. 2019

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Background: A surgical site infection (SSI) is believed to be the result of an exaggerated inflammatory response. Objective: Examine the relationship between clinical status and inflammation biomarkers in full-thickness skin grafting wounds. Methods: Twenty patients planned for facial full-thickness skin grafting were enrolled. A week after surgery, all graft wounds were clinically assessed using a 3-step scale for inflammation (low, moderate, high). All wounds were swabbed for routine microbiological analysis and assessment of numbers of aerobic bacteria. Tie-over dressings from all patients were collected and used for wound fluid extraction and subsequent analysis of MMPs, cytokines, and NF-κB inducing activity. Results: Wounds with a high degree of inflammation contained increased total MMP activity ( P ≤ 0.05) in their corresponding fluids. Likewise, the level of the cytokines IL-1ß, IL-8, IL-6, TNF-α was analyzed, and particularly IL-1ß was discriminatory for highly inflamed wounds ( P ≤ 0.01). Moreover, bacterial loads were increased in highly inflamed wounds compared to wounds with a low degree of inflammation ( P ≤ 0.01). NF-κB activation in the monocytic cell line THP-1 was significantly higher when these cells were stimulated by wound fluids with a high degree of inflammation ( P ≤ 0.01). Growth of S. aureus in wounds did not vary between wounds with different degrees of inflammation (chi-square 3.8, P = 0.144). Conclusion: Biomarkers analyzed from tie-over dressings correlated to clinical wound healing in full-thickness skin grafting.

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“…In a similar vein, another study demonstrated statistical differences between patients with and without surgical site infection (SSI) after cervical neck dissection on postsurgical drainage fluid cytokine levels, including IL-1 β , IL-2, IL-6, IL-8, and TNF- α [38]. IL-10 was the only cytokine not associated with SSI.…”

Section: Role Of Cytokines and Their Clinical Cutoffs In Infectionmentioning

confidence: 95%

Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels

Monastero

Pentyala

2017

International Journal of Inflammation

172

129

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Cytokines, including interleukins, interferons, tumor necrosis factors, and chemokines, have a variety of pro- and anti-inflammatory effects in the body through a number of biochemical pathways and interactions. Stimuli, actions, interactions, and downstream effects of cytokines have been investigated in more depth in recent years, and clinical research has also been conducted to implicate cytokines in causal patterns in certain diseases. However, particular cutoffs of cytokines as biomarkers for disease processes have not been well studied, and this warrants future work to potentially improve diagnoses for diseases with inflammatory markers. A limited number of studies in this area are reviewed, considering diseases correlated with abnormal cytokine profiles, as well as specific cutoffs at which cytokines have been deemed clinically useful for diagnosing those diseases through Receiver Operator Characteristics modeling. In light of studies such as those discussed in this review, cytokine testing has the potential to support diagnosis due to its lack of invasiveness and low cost, compared to other common types of testing for infections and inflammatory diseases.

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Early Modification in Drainage of Interleukin-1β and Tumor Necrosis Factor-α Best Predicts Surgical-Site Infection After Cervical Neck Dissection for Oral Cancer

Cited by 12 publications

References 44 publications

The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting

Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels

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