Early metabolic and hemodynamic indicators of kidney dysfunction in mice offspring from parental low protein diet
Fabiola Diniz,
Francesca Edgington-Giordano,
Samir S. El-Dahr
et al.
Abstract:Background
Parental malnutrition, particularly a low-protein diet (LPD), causes oligonephropathy at birth and predisposes offspring to hypertension and chronic kidney disease later in life. The onset of adult kidney disease varies based on genetics and environmental factors, often with subclinical alterations in kidney function being overlooked. This study aimed to examine changes in kidney morphology before significant kidney function decline in the offspring of mice fed a low-protein diet.
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