Early menarche and premature natural menopause in Indonesia

Andarini, Sri; Sujarwoto, Sujarwoto

doi:10.1080/03014460.2018.1523461

Cited by 8 publications

(7 citation statements)

References 30 publications

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“…3) whereby germline mutation burdens may be plateaued in the prepubertal years, with the establishment of adult germline mutation accumulation rates occurring sometime during adolescence, perhaps triggered by the onset of puberty. This model is consistent with previous reports suggesting that later puberty is associated with longer lifespans [29][30][31] , reduced cancer risks 32 , and later menopause [33][34][35][36] , as would be expected if puberty triggers a resumption of mutation accumulation, and consequently ageing, in both germline and somatic tissues.…”

Section: Discussionsupporting

confidence: 92%

“…Developmental deficiency of the GH/IGF-1 axis in dwarf mice keeps IGF-1 levels in blood low, prevents the normal decline in DNA repair of adulthood, and significantly extends lifespan 28 . Also, polygenic risk scores for later onset of puberty in humans are associated with longer lifespans in both sexes 29 ; and later puberty is associated with decreased all-cause mortality in women 30,31 , reduced risk of cancer in both sexes 32 , and later menopause [33][34][35][36] . All of these associations are expected if mutation accumulation rates rise after puberty and contribute to both systemic and reproductive ageing.…”

mentioning

confidence: 99%

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Germline mutation rates in young adults predict longevity and reproductive lifespan

Cawthon

Meeks

Sasani

et al. 2020

Sci Rep

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Ageing may be due to mutation accumulation across the lifespan, leading to tissue dysfunction, disease, and death. We tested whether germline autosomal mutation rates in young adults predict their remaining survival, and, for women, their reproductive lifespans. Age-adjusted mutation rates (AAMRs) in 61 women and 61 men from the Utah CEPH (Centre d'Etude du Polymorphisme Humain) families were determined. Age at death, cause of death, all-site cancer incidence, and reproductive histories were provided by the Utah Population Database, Utah Cancer Registry, and Utah Genetic Reference Project. Higher AAMRs were significantly associated with higher all-cause mortality in both sexes combined. Subjects in the top quartile of AAMRs experienced more than twice the mortality of bottom quartile subjects (hazard ratio [HR], 2.07; 95% confidence interval [CI], 1.21-3.56; p = 0.008; median survival difference = 4.7 years). Fertility analyses were restricted to women whose age at last birth (ALB) was ≥ 30 years, the age when fertility begins to decline. Women with higher AAMRs had significantly fewer live births and a younger ALB. Adult germline mutation accumulation rates are established in adolescence, and later menarche in women is associated with delayed mutation accumulation. We conclude that germline mutation rates in healthy young adults may provide a measure of both reproductive and systemic ageing. puberty may induce the establishment of adult mutation accumulation rates, just when DnA repair systems begin their lifelong decline.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

Germline mutation rates in young adults predict longevity and reproductive lifespan

Cawthon

Meeks

Sasani

et al. 2020

Sci Rep

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“…27 However, previous studies in both HICs and LMICs have showed moderate-to-high correlation (r=0.66-0.83) when comparing self-reported age earlier and later on in life. 28 One study based in Uganda triangulated the information obtained from the DHS and concluded that the DHS were very close to other studies on settings similar to the one being studied. The author went as far as saying that the quality of these data in LMICs might even be better than in HICs as the event is often of great cultural significance and therefore more likely to be remembered.…”

Section: Data Availability and Data Qualitymentioning

confidence: 75%

Timing and determinants of age at menarche in low-income and middle-income countries

Leone

Brown

2020

BMJ Glob Health

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IntroductionUnderstanding the timing and determinants of age at menarche is key to determining potential linkages between onset of puberty and health outcomes from a life-course perspective. Yet, we have little information in low-income and middle-income countries (LMICs) mainly due to lack of data. The aim of this study was to analyse trends in the timing and the determinants of menarche in LMICs.MethodsUsing 16 World Fertility Survey and 28 Demographic and Health Surveys (DHS) from 27 countries, we analysed cohort trends and used fixed-effects models for DHS surveys to investigate sociodemographic and regional effects in the timing of age at menarche.ResultsTrends of the mean age at menarche across time within and between countries show a declining or stalling path. Results of the determinant modelling show the relationship with wealth changes over time although not consistently across countries. We see a shift from poorer women having earlier menarche in earlier surveys to richer women having earlier menarche in later surveys in Indonesia, the Philippines and Yemen, while in Egypt, the reverse pattern is evident.ConclusionsThere is a considerable gap in both literature and data on menarche. We see a trend which is declining rapidly (from 14.66 to 12.86 years for the 1932 and 2002 cohorts, respectively), possibly at a faster pace than high-income countries and with a strong link to socioeconomic status. This study calls for menarche questions to be included in more nationally representative surveys and greater use of existing data because of its impact on life-course health in fast-ageing settings. Further studies will need to investigate further the use of the age at menarche as an indicator of global health.

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“…Esta técnica de medicina alternativa proporciona estimulación sensorial especializada que se transmite a través de las vías neuronales sensoriales. 14,15 Para comprender bien sus funciones específicas se necesita un análisis de la neuroanatomía, neurofisiología y neurofarmacología,…”

Section: At E R I a L E S Y M é To D O Sunclassified

“…[4][5][6][7][8][9] Si bien todos los síntomas a menudo anuncian la aparición de la menopausia, muchos otros órganos y sistemas se ven afectados como consecuencia de la disminución de las concentraciones del estrógeno. [10][11][12][13] Dado que casi todos los tejidos (huesos, sistema cardiovascular y nervioso central, tracto gastrointestinal y urogenital) expresan receptores de estrógenos, se afectan de alguna manera por la disminución, 14 aunque también se ven comprometidos por el envejecimiento. 15 No todas las mujeres que manifiestan síntomas menopaúsicos pueden utilizar la terapia hormonal de reemplazo, pues hay contraindicaciones médicas (antecedentes de cáncer de mama y/o endometrio, tromboembolismo venoso activo, hepatopatía grave) o incluso la falta de consentimiento del paciente para este tipo de tratamiento (miedo a desarrollar cáncer, a subir de peso e intolerancia).…”

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Acupuntura en el control de los síntomas de la menopausia

et al. 2021

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Objetivo: establecer la efectividad de la acupuntura en el control de los síntomas de la menopausia. Materiales y métodos: se seleccionaron menopaúsicas sanas entre 48 y 57 años que presentaban síntomas relacionados con la menopausia que no recibían terapia hormonal. El tratamiento consistió en 24 sesiones de acupuntura y se evaluó la intensidad de los síntomas con el puntaje del índice de Kupperman antes de iniciar y a las 4 y 8 semanas después de iniciadas las sesiones de acupuntura. Resultados: en 50 menopáusicas con edad promedio de 53,4 +/- 3,2 años después de 4 y 8 semanas de tratamiento no se observaron diferencias estadísticamente significativas en la intensidad de calorones, sudoración, trastorno del sueño, depresión, vértigo, cefalea, artralgia, palpitaciones, debilidad y síntomas vaginales (p = ns). El valor promedio de índice de Kupperman inicial fue de 30,6 +/- 4,7 puntos, el cual aumentó a 32,1 +/- 5,6 puntos a las cuatro semanas para luego alcanzar un valor de 31,1 +/- 4,8 puntos a las 8 semanas. No se demostraron diferencias significativas en los valores promedio de la escala a las 4 (p = 0,150) y 8 semanas (p = 0,596). Conclusión: la acupuntura no es efectiva para controlar los síntomas causados por la menopausia, por lo que no es una alternativa de la terapia de reemplazo hormonal.

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Early menarche and premature natural menopause in Indonesia

Cited by 8 publications

References 30 publications

Germline mutation rates in young adults predict longevity and reproductive lifespan

Germline mutation rates in young adults predict longevity and reproductive lifespan

Timing and determinants of age at menarche in low-income and middle-income countries

Acupuntura en el control de los síntomas de la menopausia

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