Early membrane initiated transcriptional effects of estrogens in breast cancer cells: First pharmacological evidence for a novel membrane estrogen receptor element (ERx)

Kampa, Marilena; Notas, George; Pelekanou, Vassiliki; Troullinaki, Maria; Andrianaki, Maria; Azariadis, Kalliopi; Kampouri, Eleftheria; Lavrentaki, Katerina; Castanas, Elias

doi:10.1016/j.steroids.2012.02.011

Cited by 26 publications

(30 citation statements)

References 53 publications

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“…A different receptor, functionally distinct form of ERα and ERβ, was identified by Almey et al [49] and was named ER-X. ER-X can be illustrious from previously labeled receptors inter alia by its molecular weight which is 63 kDa, while the molecular weight of ERα, ERβ, and Gpr30 was 67 kDa, 60 kDa, and 44 kDa, respectively [50]. Additionally, it does not involve in the stimulation of extracellular signal-controlled kinases in the presence of selective estrogen receptor agonists and responds more powerfully to 17α than 17β estradiol [45].…”

Section: Membrane Receptors Specific To Estrogensmentioning

confidence: 99%

“…Additionally, it does not involve in the stimulation of extracellular signal-controlled kinases in the presence of selective estrogen receptor agonists and responds more powerfully to 17α than 17β estradiol [45]. ere was an another discovery of receptor in T47D and MCF-7 cells by Kampa et al [50] which are related to cell signaling, apoptosis, and transcriptional regulation [51]. e receptor was surprisingly named ERx even though there is no proof that ER-X and Erx are associated.…”

Section: Membrane Receptors Specific To Estrogensmentioning

confidence: 99%

“…[45] Worth mentioning, the existing mechanism is about mERα only. erefore, comprehensive research of the mechanisms of estrogen exploit necessitates more broad research in view of the exact membrane and nuclear estrogen receptors and the nonspecific interactions [50].…”

Section: Membrane Receptors Specific To Estrogensmentioning

confidence: 99%

See 2 more Smart Citations

A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish

Amenyogbe

Chen

Wang

et al. 2020

International Journal of Endocrinology

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Steroid hormones play essential roles in the reproductive biology of vertebrates. Estrogen exercises its effect through estrogen receptors and is not only a female reproductive hormone but acts virtually in all vertebrates, including fish, and is involved in the physiological and pathological states in all males and females. Estrogen has been implicated in mandible conservation and circulatory and central nervous systems as well as the reproductive system. is review intended to understand the structure, function, binding affinities, and activations of estrogens and estrogen receptors and to discuss the understanding of the role of sex steroid hormone estrogen receptors in mammals and fish.

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Section: Membrane Receptors Specific To Estrogensmentioning

confidence: 99%

Section: Membrane Receptors Specific To Estrogensmentioning

confidence: 99%

See 1 more Smart Citation

A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish

Amenyogbe

Chen

Wang

et al. 2020

International Journal of Endocrinology

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“…It is relevant to mention that except for the well-known classical ERs and GPER, several novel membrane-associated receptors such as ER-X [48], ER-x [49] and STX-binding protein [50] have been proposed as oestrogen receptors. Since the definition of ERs is missing, it remains a matter of debate whether these later described receptors are really oestrogen receptors [51], and their further characterization is required.…”

Section: Oestrogen Receptorsmentioning

confidence: 99%

“…ER-X has a sequence homology to ERα, binds estradiol with high affinity, activates extracellular signal-regulated kinases ERK1/2, is developmentally regulated in the neocortex and uterus with maximal expression at postnatal days 7–10, and may be re-expressed in the adult brain after injury [48]. ER-x was described as a membrane ER that mediates oestrogen signalling in some breast cancer cell lines, leading to the modulation of apoptosis, growth factor signalling and transcriptional regulation [49]. Whether these receptors also play a role in male reproduction remains to be determined.…”

Section: Oestrogen Receptorsmentioning

confidence: 99%

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Dostalova

Žatecká

Dvořáková-Hortová

2017

IJMS

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The crucial role that oestrogens play in male reproduction has been generally accepted; however, the exact mechanism of their action is not entirely clear and there is still much more to be clarified. The oestrogen response is mediated through oestrogen receptors, as well as classical oestrogen receptors’ variants, and their specific co-expression plays a critical role. The importance of oestrogen signalling in male fertility is indicated by the adverse effects of selected oestrogen-like compounds, and their interaction with oestrogen receptors was proven to cause pathologies. The aims of this review are to summarise the current knowledge on oestrogen signalling during spermatogenesis and sperm maturation and discuss the available information on oestrogen receptors and their splice variants. An overview is given of species-specific differences including in humans, along with a detailed summary of the methodology outcome, including all the genetically manipulated models available to date. This review provides coherent information on the recently discovered mechanisms of oestrogens’ and oestrogen receptors’ effects and action in both testicular somatic and germ cells, as well as in mature sperm, available for mammals, including humans.

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Genistein Modulates Proliferation and Mitochondrial Functionality in Breast Cancer Cells Depending on ERalpha/ERbeta Ratio

Pons

Nadal-Serrano

Blanquer-Rosselló

et al. 2014

J of Cellular Biochemistry

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Breast cancer is the most common malignancy in women of developed countries. The aim of this study was to investigate whether genistein, a soy phytoestrogen, and 17β-estradiol (E2) could have effects on the cell cycle and mitochondrial function and dynamics. Three human breast cancer cell lines with different estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) ratio were used: MCF-7 (high ERα/ERβ ratio), T47D (low ERα/ERβ ratio) and MDA-MB-231 (ER-negative). Cell proliferation, cell cycle, mitochondrial functionality, and mitochondrial dynamics parameters were analyzed. E2 and genistein treatment induced cell proliferation and apoptosis inhibition in MCF-7, but not in T47D and MDA-MB-231. Moreover, genistein treatment produced an up-regulation of ERβ and a rise in cytochrome c oxidase activity in T47D cells, decreasing the ATP synthase/cytochrome c oxidase ratio. Finally, genistein treatment produced a drop in mitochondrial dynamics only in MCF-7 cells. In summary, the beneficial effects of genistein consumption depend on the ERα/ERβ ratio in breast cells. Therefore, genistein treatment produces cell cycle arrest and an improvement of mitochondrial functionality in T47D cells with a low ERα/ERβ ratio, but not in MCF-7 (high ERα/ERβ ratio) and MDA-MB-231 (ER-negative) ones.

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Early membrane initiated transcriptional effects of estrogens in breast cancer cells: First pharmacological evidence for a novel membrane estrogen receptor element (ERx)

Cited by 26 publications

References 53 publications

A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish

A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Genistein Modulates Proliferation and Mitochondrial Functionality in Breast Cancer Cells Depending on ERalpha/ERbeta Ratio

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