Early measurements of portal pressure predicts survival in cirrhotic patients with acute variceal hemorrhage

Ruíz-del-Árbol, Luís; Monescillo, Alberto; Gonzalez, M.; Urmán, Jesús; González-García, Mauricio; Peña, E.; Cano, A.; Moreira, V.

doi:10.1016/s0168-8278(03)80600-1

Cited by 3 publications

(3 citation statements)

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“…Indeed, the administration of human albumin lowered the incidence of PCD [115] and its complications, such as hyponatremia and mortality [116]. The second PAVH-inspired indication was the prevention of HRS-AKI following spontaneous bacterial peritonitis (SBP), a lethal complication due to enhanced arterial vasodilation and reduced cardiac output [117]. The prevalence of HRS-AKI and hospital mortality decreased by 60% in patients treated with antibiotics plus human albumin compared to patients receiving antibiotics alone [118].…”

Section: Pavh-based Treatments: a New Perspectivementioning

confidence: 99%

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

Bernardi

Moreau

Angeli

et al. 2015

Journal of Hepatology

502

451

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Section: Pavh-based Treatments: a New Perspectivementioning

confidence: 99%

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

Bernardi

Moreau

Angeli

et al. 2015

Journal of Hepatology

502

451

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“…Majority of patients with CCM in our cohort only had a mild DD and previous studies have shown that HRS develops in patients with systolic dysfunction; as these patients have low cardiac output. (14,38) Patients who developed HRS in our study had higher CTP, MELD, and HVPG scores.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 48%

A Prospective Study of Prevalence and Predictors of Cirrhotic Cardiomyopathy and Its Role in Development of Hepatorenal Syndrome

Anikhindi

Ranjan

Kumar

et al. 2022

Journal of Clinical and Experimental Hepatology

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“…24 In another study of 23 patients with spontaneous bacterial peritonitis (SBP) at diagnosis and after resolution of infection, those who developed HRS had a significantly lower cardiac output at the time of diagnosis of SBP, compared with those who did not develop HRS, indicating a relationship between HRS and diminished cardiac output. 25 The pathophysiological hallmark of HRS is vasoconstriction of the renal circulation. 26,27 Marked renal vasoconstriction in patients with HRS has been demonstrated in a number of studies.…”

Section: Circulatory Dysfunctionmentioning

confidence: 99%

Hepatorenal syndrome: Current concepts and future perspectives

Jung¹,

Chang²

2023

Clin Mol Hepatol

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Hepatorenal syndrome (HRS), a progressive but potentially reversible deterioration of kidney function, remains a major complication in patients with advanced cirrhosis, often leading to death before liver transplantation (LT). Recent updates in the pathophysiology, definition, and classification of HRS have led to a complete revision of the nomenclature and diagnostic criteria for HRS type 1, which was renamed HRS-acute kidney injury (AKI). HRS is characterized by severe impairment of kidney function due to increased splanchnic blood flow, activation of several vasoconstriction factors, severe vasoconstriction of the renal arteries in the absence of kidney histologic abnormalities, nitric oxide dysfunction, and systemic inflammation. Diagnosis of HRS remains a challenge because of the lack of specific diagnostic biomarkers that accurately distinguishes structural from functional AKI, and mainly involves the differential diagnosis from other forms of AKI, particularly acute tubular necrosis (ATN). The optimal treatment of HRS is LT. While awaiting LT, treatment options include vasoconstrictor drugs to counteract splanchnic arterial vasodilation and plasma volume expansion by intravenous albumin infusion. In patients with HRS unresponsive to pharmacological treatment and with conventional indications for kidney replacement therapy (KRT), such as volume overload, uremia, or electrolyte imbalances, KRT may be applied as a bridging therapy to transplantation. Other interventions, such as transjugular intrahepatic portosystemic shunt, and artificial liver support systems have a very limited role in improving outcomes in HRS. Although recently developed novel therapies have potential to improve outcomes of patients with HRS, further studies are warranted to validate the efficacy of these novel agents.

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Early measurements of portal pressure predicts survival in cirrhotic patients with acute variceal hemorrhage

Cited by 3 publications

References 0 publications

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

A Prospective Study of Prevalence and Predictors of Cirrhotic Cardiomyopathy and Its Role in Development of Hepatorenal Syndrome

Hepatorenal syndrome: Current concepts and future perspectives

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