Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus

Kuma, Hiromi; Miki, Takanori; Matsumoto, Yoshiki; He, Gu; Liu, Hongpeng; Kusaka, Takashi; Satriotomo, Irawan; Okamoto, Hanayo; Yokoyama, Toshifumi; Bedi, K. S.; Onishi, Shoju; Sekiya, Hiroshi; Takeuchi, Yoshiki

doi:10.1016/j.neulet.2004.09.012

Cited by 51 publications

(34 citation statements)

References 38 publications

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“…The increase in CR and CB positive neurons in EH and DEP rats might represent a differential response to increased growth factors expression. In fact, maternal separation can induce the expression of nerve growth factor and brain-derived neurotrophic factor (BDNF) in different brain regions, including the hippocampus, in preweaning and adolescent rats Kuma et al, 2004;Roceri et al, 2004). Moreover, BDNF supports differentiation of CR and CB immunoreactive nonpyramidal neurons in organotypic slice cultures from the early postnatal rat hippocampus (Marty et al, 1996).…”

Section: Maternal Separation Differently Affects Cr Cb and Pv In Hipmentioning

confidence: 99%

Maternal deprivation and early handling affect density of calcium binding protein-containing neurons in selected brain regions and emotional behavior in periadolescent rats

et al. 2007

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Section: Maternal Separation Differently Affects Cr Cb and Pv In Hipmentioning

confidence: 99%

Maternal deprivation and early handling affect density of calcium binding protein-containing neurons in selected brain regions and emotional behavior in periadolescent rats

et al. 2007

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“…Preclinical studies also suggested that stress in early life could cause long-term changes in the expression of BDNF and CREB in the hippocampus (Kuma et al 2004;Greisen et al 2005;Morinobu et al 2006;Lippmann et al 2007;Nair et al 2007). This suggests that alterations in BDNF/CREB may contribute to generation of individual differences in stress neurocircuitry, altering vulnerability to depressive disorders.…”

Section: Introductionmentioning

confidence: 99%

Blunted Behavioral and Molecular Responses to Chronic Mild Stress in Adult Rats with Experience of Infancy Maternal Separation

Shu

Xiao

Tang³

et al. 2015

Tohoku J. Exp. Med.

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Childhood adversity has profound and persistent effects on brain functions and has been implicated in the etiology of depression. Brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) play critical roles during brain development to maintain neuronal function and structural integrity in adulthood. We therefore investigated the long-term effects of early life adversity on the depression-related behavior and the expression of BDNF and CREB in the hippocampus. Male SpragueDawley newborn rats were subjected to maternal separation for 3 h/day on postnatal days 2-14. After the postnatal day 90, rats with or without the experience of infancy maternal separation received a series of unpredictable chronic mild stress (CMS) for 21 days. Sucrose preference and spontaneous activity in the open field test were recorded, and the expression of BDNF and CREB in the hippocampus was measured by real-time RT-PCR and Western blot analyses. Before exposure to CMS, the rats with maternal separation showed the significant decreases in sucrose preference, spontaneous activity, and hippocampal expression of BDNF and CREB, compared to the animals without maternal separation. In contrast, the rats without maternal separation showed greater decreases of the above indictors after CMS, the levels of which were lower than those observed in the rats with maternal separation. Thus, early life adversity leads to long-term decreases in the capacity of enjoying sweetness, spontaneous activity, and hippocampal expression of BDNF and CREB. Moreover, childhood neglect may decrease the neurobehavioral plasticity, thereby blunting the responses to adulthood stress and increasing the susceptibility to depression.

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“…1a and B). real-time RT-PCR was performed as previously described (27)(28)(29). To verify whether specific amplification had been accomplished, melting curve analysis was used to verify that the Pcr products amplified from the target and housekeeping genes had a single and sharp transition (data not shown), confirming that a single Pcr product was present.…”

Section: Resultsmentioning

confidence: 99%

Nerve growth factor and receptors are significantly affected by histamine stimulus through H1 receptor in pancreatic carcinoma cells

Wang

Ding²,

Miki³

et al. 2009

Mol Med Rep

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Abstract. nerve growth factor (nGF) as an autocrine or paracrine growth factor plays a critical role in the pathogenesis and progression of human pancreatic cancer. nGF is synthesized as a proform (pronGF) that, when cleaved, releases mature ligand (mnGF). pronGF and mnGF bind to high-affinity tyrosine kinase receptor A (TrkA) and lowaffinity receptor p75 to different extents. Histamine is a potent stimulator of NGF in the inflammatory lesion as determined by eliSa. This has generally been attributed to the accumulation of mnGF. To determine the effect of histamine on nerve growth factor/receptor expression in human pancreatic cancer, the present study explored intracellular and extracellular NGF production and p75 and TrkA membrane receptor expression in the PANC-1, KMP-6 and PK-1 cell lines. Histamine enhanced NGF secretion and mRNA expression in PANC-1 and KMP-6 cells, but not in PK-1 cells. proNGF was revealed using Western blotting to be the predominant form of NGF, but was significantly reduced by histamine. p75 receptor binding was increased with histamine treatement, but no significant alteration was observed for TrkA. Proliferating cell nuclear antigen (Pcna), an important indicator of cell proliferation, was significantly reduced by histamine stimulation. H 1 and H 2 receptors were both observed in the pancreatic cancer cells, and the alterations induced by histamine were counteracted by H 1 receptor antagonist pyrilamine; however, the H 2 receptor subtype was excluded from this process. These results suggest that histamine induces distinct nerve growth factor/receptor responsiveness via H 1 receptor-induced signaling, thus affecting pancreatic cancer cell proliferation.

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Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus

Cited by 51 publications

References 38 publications

Maternal deprivation and early handling affect density of calcium binding protein-containing neurons in selected brain regions and emotional behavior in periadolescent rats

Maternal deprivation and early handling affect density of calcium binding protein-containing neurons in selected brain regions and emotional behavior in periadolescent rats

Blunted Behavioral and Molecular Responses to Chronic Mild Stress in Adult Rats with Experience of Infancy Maternal Separation

Nerve growth factor and receptors are significantly affected by histamine stimulus through H1 receptor in pancreatic carcinoma cells

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