Early Markers of Brain Damage in Premature Low-Birth-Weight Neonates Who Suffered from Perinatal Asphyxia and/or Infection

Fotopoulos, S; Pavlou, Kyriaki; Skouteli, Helen; Papassotiriou, Ioannis; Lipsou, Niki; Xanthou, M

doi:10.1159/000047094

Cited by 27 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A significant increase of IL-6 in the serum samples of PNH group compared with control group, observed in our study, is in agreement with this observation. Similar results have been found in other studies [29][30][31]. Moreover, some studies showed significantly higher values of IL-6 in CSF samples of children with asphyxia, but the serum samples were not tested in those studies [9,11,12,29].…”

Section: Discussionsupporting

confidence: 87%

“…While some studies found significantly higher levels of TNF-α in CSF samples, other studies demonstrated higher TNF-α levels in serum samples of hypoxic newborns [11,12]. In addition, some studies did not find increased levels of TNF-α after hypoxic injury [31,38]. In their study, Aly et al confirmed increased levels of TNF-α in both, serum and CSF samples [12].…”

Section: Discussionmentioning

confidence: 89%

“…IL-1β and TNF-α are the best characterized early response cytokines and are often expressed concurrently [34][35][36]. In [31,37]. IL-1β and TNF-α can affect the progression of injury, as well as the process of healing, by stimulating the synthesis of other cytokines.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia

Šumanović-Glamuzina

Čulo

et al. 2017

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Perinatal hypoxia-ischemia is a specific and important pathological event in neonatal care practice. The data on relationship between the concentrations of cytokines in blood and cerebrospinal fluid (CSF) and perinatal brain injury are scarce. The aim of this study is to evaluate changes in interleukin (IL-1β, IL-6, and IL-18) and tumor necrosis factor alpha (TNF-α) levels in newborns with perinatal hypoxia (PNH). CSF and serum samples of 35 term and near-term (35-40 weeks) newborns with PNH, at the age of 3-96 hours, were analyzed using enzyme-linked immunosorbent assay. Control group consisted of 25 non-asphyxic/non-hypoxic infants of the same age sampled for clinically suspected perinatal meningitis, but proven negative and healthy otherwise. The cytokine values in CSF and serum samples were determined in relation to initial hypoxic-ischemic encephalopathy (HIE) staged according the Sarnat/Sarnat method, and compared with neurological outcome at 12 months of age estimated using Amiel-Tison procedure. The concentrations of IL-6 and TNF-α in serum of PNH patients were significantly higher compared to control group (p = 0.0407 and p = 0.023, respectively). No significant difference between average values of cytokines in relation to the stage of HIE was observed. Significantly higher levels of IL-6 and IL-18 corresponded to a mildly abnormal neurological outcome, while higher levels of IL-6 and TNF-α corresponded to a severely abnormal neurological outcome, at 12 months of age. Elevated serum levels of IL-6 and TNF-α better corresponded with hypoxia/ischemia compared to CSF values, within 96 hours of birth. Also, higher serum levels of IL-6, TNF-α, and IL-18 corresponded better with abnormal neurological outcome at 12 months of age, compared to CSF values.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia

Šumanović-Glamuzina

Čulo

et al. 2017

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

show abstract

“…Nearly 50% of term-born infants suffering severe HIE die within weeks of birth, while up to 25% of those surviving exhibit permanent neuropsychological dysfunction [7]. Similarly, a 50% mortality rate exists for preterm infants experiencing severe HI, with 80% of survivors experiencing long-term complications [19], including reductions in cerebellar [20], cortical, and hippocampal volumes [21] associated in turn with cognitive and behavioral deficits, deficits in verbal and language domains [22, 23], reduced IQ measures [24], cerebral palsy, and mental retardation [25]. What is surprising, however, is the disproportionate incidence of, and increased severity of effects following, neonatal HI injury in males.…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models: Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice

Hill

Fitch

2012

Neurology Research International

169

144

View full text Add to dashboard Cite

Clinical findings show that male infants with hypoxic-ischemic injury (HI) fare more poorly than matched females on cognitive outcomes. Rodent models of neonatal hypoxia-ischemia support this difference, with data showing that perinatal brain injury leads to long-term behavioral deficits primarily in male rodents and in female rodents treated with early androgens. Results support the idea that sex-specific gonadal hormones may modulate developmental response to injury and dovetail with overwhelming evidence of developmental androgen effects on typical brain morphology and behavior. However, mechanisms underlying sex differences in response to early brain injury may be more complicated. Specifically, activation of cell death pathways in response to HI may also differ by sex. In females, the preferential activation of the caspase-dependent apoptotic pathway may actually afford greater protection, potentially due to the actions of X-linked inhibitor of apoptosis (XIAP) within this pathway. This contrasts the pattern of preferential activation of the caspase-independent pathway in males. While an integrated model of sex-specific hormonal and genetic modulation of response to early injury remains to be fully elucidated, these findings suggest that infants might benefit from sex-specific neuroprotection following HI injury.

show abstract

“…Due to medical advances, more infants with HI now survive than in the past, leading to an increase in the numbers of children with associated behavioral deficits later in life [2,27,28,29,30,31]. Indeed, despite the varying etiologies noted above, both term and preterm HI populations show increased frequencies of language deficits [32,33,34,35,36,37], memory impairments [38,39,40,41] and developmental disorders such as ADHD [31,42,43,44,45,46,47].…”

Section: Introductionmentioning

confidence: 99%

Spatial Working Memory Deficits in Male Rats Following Neonatal Hypoxic Ischemic Brain Injury Can Be Attenuated by Task Modifications

et al. 2014

View full text Add to dashboard Cite

Hypoxia-ischemia (HI; reduction in blood/oxygen supply) is common in infants with serious birth complications, such as prolonged labor and cord prolapse, as well as in infants born prematurely (<37 weeks gestational age; GA). Most often, HI can lead to brain injury in the form of cortical and subcortical damage, as well as later cognitive/behavioral deficits. A common domain of impairment is working memory, which can be associated with heightened incidence of developmental disorders. To further characterize these clinical issues, the current investigation describes data from a rodent model of HI induced on postnatal (P)7, an age comparable to a term (GA 36–38) human. Specifically, we sought to assess working memory using an eight-arm radial water maze paradigm. Study 1 used a modified version of the paradigm, which requires a step-wise change in spatial memory via progressively more difficult tasks, as well as multiple daily trials for extra learning opportunity. Results were surprising and revealed a small HI deficit only for the final and most difficult condition, when a delay before test trial was introduced. Study 2 again used the modified radial arm maze, but presented the most difficult condition from the start, and only one daily test trial. Here, results were expected and revealed a robust and consistent HI deficit across all weeks. Combined results indicate that male HI rats can learn a difficult spatial working memory task if it is presented in a graded multi-trial format, but performance is poor and does not appear to remediate if the task is presented with high initial memory demand. Male HI rats in both studies displayed impulsive characteristics throughout testing evidenced as reduced choice latencies despite more errors. This aspect of behavioral results is consistent with impulsiveness as a core symptom of ADHD—a diagnosis common in children with HI insult. Overall findings suggest that task specific behavioral modifications are crucial to accommodating memory deficits in children suffering from cognitive impairments following neonatal HI.

show abstract

Early Markers of Brain Damage in Premature Low-Birth-Weight Neonates Who Suffered from Perinatal Asphyxia and/or Infection

Cited by 27 publications

References 43 publications

A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia

A comparison of blood and cerebrospinal fluid cytokines (IL-1β, IL-6, IL-18, TNF-α) in neonates with perinatal hypoxia

Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models: Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice

Spatial Working Memory Deficits in Male Rats Following Neonatal Hypoxic Ischemic Brain Injury Can Be Attenuated by Task Modifications

Contact Info

Product

Resources

About