Early Markers For Cerebral Palsy: Insights From the Assessment of General Movements

Einspieler, Christa; Marschik, Peter B.; Bos, Arend F.; Ferrari, Fabrizio; Cioni, Giovanni; Prechtl, H.F.R.

doi:10.2217/fnl.12.60

Cited by 65 publications

(87 citation statements)

References 64 publications

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“…Reference lists of three other systematic reviews assessing the Prechtl GMA 12,23,24 and a key review article 25 were also screened. Reference lists of three other systematic reviews assessing the Prechtl GMA 12,23,24 and a key review article 25 were also screened.…”

Section: Methodsmentioning

confidence: 99%

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

Kwong

FitzGerald

Doyle

et al. 2018

Develop Med Child Neuro

155

134

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Section: Methodsmentioning

confidence: 99%

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

Kwong

FitzGerald

Doyle

et al. 2018

Develop Med Child Neuro

155

134

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“…Quite apart from the lack of FMs, infants with an increased risk of non-spastic CP showed circular arm movements with or without spread fingers. 12,36 Infants who went on to develop unilateral CP showed an asymmetry of distal segmental movements, which were reduced or absent on the contralateral side of the lesion. 37---39 A crampedsynchronized movement character, repetitive opening and closing of the mouth, repetitive kicking, and abnormal finger postures characterized children who would later demonstrate poor self-mobility.…”

Section: Normal Fmsmentioning

confidence: 99%

“…13 Apart from normal vs. abnormal (cramped-synchronized) 6 writhing GMs, it is mainly FMs that contribute to excellent predictive values. 6,9,12,13 …”

Section: Introductionmentioning

confidence: 99%

Fidgety movements – tiny in appearance, but huge in impact

Einspieler

Peharz

Marschik

2016

Jornal de Pediatria

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127

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Abnormal, absent, or sporadic FMs indicate an increased risk for later neurological dysfunction, whereas normal FMs are highly predictive of normal development, especially if they co-occur with other smooth and fluent movements. Early recognition of neurological signs facilitates early intervention. It is important to re-assure parents of infants with clinical risk factors that the neurological outcome will be adequate if FMs develop normally.

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“…Monitoring will also include neurological assessment (HINE) and recording of spontaneous activity according to Prechtl (GMA) [25, 26]. …”

Section: Methodsmentioning

confidence: 99%

Early intervention at home in infants with congenital brain lesion with CareToy revised: a RCT protocol

Sgandurra

Beani

Giampietri³

et al. 2018

BMC Pediatr

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BackgroundCongenital brain lesions expose infants to be at high-risk for being affected by neurodevelopmental disorders such as cerebral palsy (CP). Early interventions programs can significantly impact and improve their neurodevelopment. Recently, in the framework of the European CareToy (CT) Project (www.caretoy.eu), a new medical device has been created to deliver an early, intensive, customized, intervention program, carried out at home by parents but remotely managed by expert and trained clinicians. Reviewing results of previous studies on preterm infants without congenital brain lesion, the CT platform has been revised and a new system created (CT-R).This study describes the protocol of a randomised controlled trial (RCT) aimed to evaluate, in a sample of infants at high-risk for CP, the efficacy of CT-R intervention compared to the Infant Massage (IM) intervention.Methods/designThis RCT will be multi-centre, paired and evaluator-blinded. Eligible subjects will be preterm or full-term infants with brain lesions, in first year of age with predefined specific gross motor abilities. Recruited infants will be randomized into CT-R and IM groups at baseline (T0). Based on allocation, infants will perform an 8-week programme of personalized CareToy activities or Infant Massage. The primary outcome measure will be the Infant Motor Profile. On the basis of power calculation, it will require a sample size of 42 infants. Moreover, Peabody Developmental Motor Scales-Second Edition, Teller Acuity Cards, standardized video-recordings of parent-infant interaction and wearable sensors (Actigraphs) will be included as secondary outcome measures. Finally, parents will fill out questionnaires (Bayley Social-Emotional, Parents Stress Index). All outcome measures will be carried out at the beginning (T0) and at end of 8-weeks intervention period, primary endpoint (T1). Primary outcome and some secondary outcomes will be carried out also after 2 months from T1 and at 18 months of age (T2 and T3, respectively). The Bayley Cognitive subscale will be used as additional assessment at T3.DiscussionThis study protocol paper is the first study aimed to test CT-R system in infants at high-risk for CP. This paper will present the scientific background and trial methodology.Trial registrationNCT03211533 and NCT03234959 (www.clinicaltrials.gov).

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Early Markers For Cerebral Palsy: Insights From the Assessment of General Movements

Cited by 65 publications

References 64 publications

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

Predictive validity of spontaneous early infant movement for later cerebral palsy: a systematic review

Fidgety movements – tiny in appearance, but huge in impact

Early intervention at home in infants with congenital brain lesion with CareToy revised: a RCT protocol

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