Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease

Assar, Mariam El; Angulo, Javier; García‐Rojo, Esther; Sevilleja-Ortiz, Alejandro; García‐Gómez, Borja; Fernández, Argentina; Sánchez-Ferrer, Alberto; Fuente, José M. La; Romero‐Otero, Javier; Rodríguez‐Mañas, Leocadio

doi:10.1007/s11357-021-00507-x

Cited by 10 publications

(19 citation statements)

References 63 publications

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“…Aging is the main risk factor for CVD, even in the absence of traditional risk factors, while CVD is considered the principal contributor to morbidity and mortality in older populations [ 104 , 105 ]. The aging process is associated with both structural and functional alterations at the vascular level, leading not only to an increase in cardiovascular events in older subjects but also to functional decline, cognitive deterioration, and frailty [ 9 , 106 ].…”

Section: Aging-related Changes In Skeletal Muscle and Cardiovascular ...mentioning

confidence: 99%

“…Evidence derived from longitudinal studies has demonstrated that vascular aging is associated with two specific arterial phenotypes: endothelial dysfunction and an increased stiffness of the large elastic arteries [ 27 ]. In fact, different researchers have clearly demonstrated the presence of endothelial dysfunction, manifested by impaired endothelium-dependent vasodilation, associated with the aging process in the micro- and macrovasculature of animal models and humans [ 106 , 107 ].…”

Section: Aging-related Changes In Skeletal Muscle and Cardiovascular ...mentioning

confidence: 99%

“…Although the mechanisms responsible for aging-related vascular dysfunction have not been completely elucidated, oxidative stress and chronic low-grade inflammation are considered the major contributors to age-related vascular dysfunction [ 106 ].…”

Section: Aging-related Changes In Skeletal Muscle and Cardiovascular ...mentioning

confidence: 99%

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Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Assar

Álvarez‐Bustos

Sosa

et al. 2022

IJMS

Self Cite

103

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Functional status is considered the main determinant of healthy aging. Impairment in skeletal muscle and the cardiovascular system, two interrelated systems, results in compromised functional status in aging. Increased oxidative stress and inflammation in older subjects constitute the background for skeletal muscle and cardiovascular system alterations. Aged skeletal muscle mass and strength impairment is related to anabolic resistance, mitochondrial dysfunction, increased oxidative stress and inflammation as well as a reduced antioxidant response and myokine profile. Arterial stiffness and endothelial function stand out as the main cardiovascular alterations related to aging, where increased systemic and vascular oxidative stress and inflammation play a key role. Physical activity and exercise training arise as modifiable determinants of functional outcomes in older persons. Exercise enhances antioxidant response, decreases age-related oxidative stress and pro-inflammatory signals, and promotes the activation of anabolic and mitochondrial biogenesis pathways in skeletal muscle. Additionally, exercise improves endothelial function and arterial stiffness by reducing inflammatory and oxidative damage signaling in vascular tissue together with an increase in antioxidant enzymes and nitric oxide availability, globally promoting functional performance and healthy aging. This review focuses on the role of oxidative stress and inflammation in aged musculoskeletal and vascular systems and how physical activity/exercise influences functional status in the elderly.

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Section: Aging-related Changes In Skeletal Muscle and Cardiovascular ...mentioning

confidence: 99%

Section: Aging-related Changes In Skeletal Muscle and Cardiovascular ...mentioning

confidence: 99%

See 1 more Smart Citation

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Assar

Álvarez‐Bustos

Sosa

et al. 2022

IJMS

Self Cite

103

View full text Add to dashboard Cite

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“…Although the underlying mechanisms of vascular dysfunction related to the aging process are not completely known, oxidative stress and inflammation stand out as two main candidates leading to vascular impairment in aging [ 7 ]. However, aging is also related to another vascular alteration that may play a role in enhanced CVD risk such as increased agonist-induced vasoconstriction [ 8 , 9 ]. It is of importance to note that the impact of aging on vascular function is rather heterogeneous depending on the vascular territory evaluated [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, aging is also related to another vascular alteration that may play a role in enhanced CVD risk such as increased agonist-induced vasoconstriction [ 8 , 9 ]. It is of importance to note that the impact of aging on vascular function is rather heterogeneous depending on the vascular territory evaluated [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Role of STIM-1 and Orai1 in Human Microvascular Aging

Assar

García‐Rojo²,

Sevilleja-Ortiz³

et al. 2022

Cells

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The impact of aging on vascular function is heterogeneous depending on the vascular territories. Calcium regulation plays a key role in vascular function and has been implicated in aging-related hypercontractility of corpus cavernosum. We aimed to evaluate stromal interaction molecule (STIM)/Orai system involvement in aging-related vascular alterations in the human macro and microvasculature. Aortae specimens and mesenteric arteries (MA), obtained from 45 organ donors, were functionally evaluated in organ chambers and wire myographs. Subjects were divided into groups either younger or older than 65-years old. The expressions of STIM-1, Orai1, and Orai3 were determined by immunofluorescence in the aorta and MA, and by Western blot in the aorta homogenates. The inhibition of STIM/Orai with YM-58483 (20 μM) reversed adrenergic hypercontractility in MA from older subjects but did not modify aging-related hypercontractility in the aortic strips. Aging was related to an increased expression of Orai1 in human aorta, while Orai1 and STIM-1 were upregulated in MA. STIM-1 and Orai1 protein expressions were inversely correlated to endothelial function in MA. Circulating levels of Orai1 were correlated with the inflammatory factor TNF-α and with the endothelial dysfunction marker asymmetric dimethylarginine. Aging is associated with an increased expression of the STIM/Orai system in human vessels with functional relevance only in the microvascular territory, suggesting its role in aging-related microvascular dysfunction.

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Long-term administration of resveratrol and MitoQ stimulates cavernosum antioxidant gene expression in a mouse castration model of erectile dysfunction

Pierre

Azeez²,

Rossetti³

et al. 2022

Life Sciences

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Early manifestation of aging-related vascular dysfunction in human penile vasculature—A potential explanation for the role of erectile dysfunction as a harbinger of systemic vascular disease

Cited by 10 publications

References 63 publications

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Functional Role of STIM-1 and Orai1 in Human Microvascular Aging

Long-term administration of resveratrol and MitoQ stimulates cavernosum antioxidant gene expression in a mouse castration model of erectile dysfunction

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