Early Lymphoid Development and Microenvironmental Cues in B-cell Acute Lymphoblastic Leukemia

Purizaca, Jessica; Meza, Isaura; Pelayo, Rosana

doi:10.1016/j.arcmed.2012.03.005

Cited by 36 publications

(37 citation statements)

References 125 publications

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“…The microenvironment of the bone marrow has been reported to support survival, differentiation and proliferation of hematopoietic progenitor cells (47), but also malignant progenitor cells of the hematopoietic system, e.g. B-cell acute lymphoblastic leukemia (B-ALL) (48). The pathway which includes the SDF-1-CXCR4 axis has been postulated to be responsible for retention of lymphoid and myeloid leukemia cells in the bone marrow (48,49).…”

Section: Discussionmentioning

confidence: 99%

“…B-cell acute lymphoblastic leukemia (B-ALL) (48). The pathway which includes the SDF-1-CXCR4 axis has been postulated to be responsible for retention of lymphoid and myeloid leukemia cells in the bone marrow (48,49). It becomes obvious that the importance of the SDF-1-CXCR4 axis in the hematopoietic system is well-discussed, but this is the first time that the SDF-1-CXCR4 axis has been reported to play a crucial role in the development and the progression of invasion and metastasis of HNSCC.…”

Section: Discussionmentioning

confidence: 99%

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SDF-1-CXCR4 axis: Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma

et al. 2013

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Stromal cell-derived factor-1α (SDF-1α), also known as CXCL12, has variable effects on a plurality of cells. CXCR4 has been identified as its corresponding receptor. The SDF-1-CXCR4 axis is postulated to be a crucial key pathway in the interaction between (cancer) stem cells and their surrounding supportive cells in the cancer stem cell niche. We evaluated the expression of CD44 as a cancer stem cell marker and of CXCR4 in human HNSCC tissue samples. Afterwards, we monitored the concentration of SDF-1 in peripheral blood samples of HNSCC patients and healthy donors. We showed that CD44 and CXCR4 are expressed in human HNSCC tissues. Markedly, CD44 showed a high expression in HNSCC cells bordering cancer stromal cells. CXCR4 was mainly expressed in HNSCC tumor nests, but not in the surrounding stromal cells. No significant difference was noted between the SDF-1 concentration in the peripheral blood of HNSCC patients compared to healthy donors. We showed that CD44, as a stem cell marker in HNSCC, is located mainly at the borderline of HNSCC tumor nests with the surrounding cells. In addition, we demonstrated that CXCR4 as the corresponding receptor to SDF-1 is highly expressed in HNSCC tumor nests, but not in the tumor stroma. We collected evidence that SDF-1-CXCR4 interaction may be a crucial pathway in cell trafficking in the cancer stem cell niche of HNSCC, while SDF-1 was not detected in the peripheral blood of HNSCC patients. The SDF-1-CXCR4 axis may play an important role in the cancer stem cell theory of HNSCC. As SDF-1α also exhibits a multitude of functional effects on HNSCC cells, such as migration and polarization, it may be possible that the SDF-1-CXCR4 axis is also involved in the pathophysiology of the progression, recurrence and metastasis of malignant disease. Understanding these interactions may help to gain further insight into these mechanisms and as such help to discover new strategies of therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

SDF-1-CXCR4 axis: Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma

et al. 2013

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“…In a book in the series In Tech, Pelayo has described the function of the microenvironment of the bone marrow in the development of ALL [58,59]. Today, it is known that the alterations not only must occur in the cancerous cells, what confers upon them the capacity for mutations and genomic instability, that changes the cycles of cell regulation and energy consumption, evades or destroys the immune system and generates mechanisms of inflammation that lead to tumor propagation [60].…”

Section: Vulnerable Periodmentioning

confidence: 99%

“…Today, it is known that the alterations not only must occur in the cancerous cells, what confers upon them the capacity for mutations and genomic instability, that changes the cycles of cell regulation and energy consumption, evades or destroys the immune system and generates mechanisms of inflammation that lead to tumor propagation [60]. In addition to all this, cancerous cells are capable of causing changes in their microenvironment to generate an environment in which a cancerous cell can form a "nest", a microenvironment that generates tumor invasion, and a microenvironment that favors the development of metastasis [58][59][60][61]. Such changes in the cells make them even more vulnerable to exposure to carcinogenic substances [62][63][64].…”

Section: Vulnerable Periodmentioning

confidence: 99%

Model for Identifying the Etiology of Acute Lymphoblastic Leukemia in Children

Mejı́a-Aranguré¹

2013

Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic

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“…So far, no studies regarding damage patterns and normal or leukemic hematopoietic progenitor differentiation have been performed. Interestingly, some candidates that could remodel hematopoietic pathways include histones [14] and fibronectin [2,15] which are released in inflammatory processes and are increased in acute myeloid leukemia, respectively.…”

Section: Research Highlightmentioning

confidence: 99%

Adult NK lineage development in humans is strengthened upon emergency

Vadillo

Pelayo

2014

Inflamm Cell Signal

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Emergency conditions such as infection demand rapid production and activation of innate immune cells to combat noxious extrinsic agents. In mice, pathogen recognition through Toll like receptors (TLR) and the resulting pro-inflammatory cytokine release induce the expansion of bone marrow hematopoietic stem cells and instruct early differentiation fates so immediate innate cell development is guaranteed. Accordingly, recent work suggests that human primitive cell populations are also capable of microbial components discrimination through TLR, a mechanism that facilitates their differentiation to myeloid lineage cells. We have now found that early lymphoid progenitor cells from adult bone marrow display TLR9 and its ligation promotes the quick development of NK lineage cells by using mechanisms that involve IL-15R up-regulation. Strikingly, this phenomenon is not obvious in their neonatal counterparts, suggesting that contribution of neonatal seminal cells to the emergent cell production in response to viral signals may differ from that of adult cells.

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Early Lymphoid Development and Microenvironmental Cues in B-cell Acute Lymphoblastic Leukemia

Cited by 36 publications

References 125 publications

SDF-1-CXCR4 axis: Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma

SDF-1-CXCR4 axis: Cell trafficking in the cancer stem cell niche of head and neck squamous cell carcinoma

Model for Identifying the Etiology of Acute Lymphoblastic Leukemia in Children

Adult NK lineage development in humans is strengthened upon emergency

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