Early Lymph Node Involvement by Mantle Cell Lymphoma Limited to the Germinal Center

Edlefsen, Kerstin L.; Greisman, Harvey A.; Yi, Hye Son; Mantei, Kristin; Fromm, Jonathan R.

doi:10.1309/ajcp6kffgtc8plvr

Cited by 17 publications

(14 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They may correspond to the circulating cells carrying the t(14;18) found in many normal individuals, and appear to have a very low malignant potential. The "in situ MCL" lesions investigated in this and other studies of individual cases 14,23,30 may correspond to a similar phenomenon. We detected the t(11;14) translocations in the eight "in situ MCL" lesions studied and in one of them we confirmed that the translocation was present in the cyclin D1-positive cells.…”

Section: Discussionsupporting

confidence: 69%

In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior

Carvajal-Cuenca¹,

Sua²,

Silva³

et al. 2011

Haematologica

139

100

View full text Add to dashboard Cite

BackgroundCyclin D1-positive B cells are occasionally found in the mantle zones of reactive lymphoid follicles, a condition that has been called "in situ mantle cell lymphoma". The clinical significance of this lesion remains uncertain. Design and MethodsThe clinical and pathological characteristics, including SOX11 expression, of 23 cases initially diagnosed as in situ mantle cell lymphoma were studied. ResultsSeventeen of the 23 cases fulfilled the criteria for in situ mantle cell lymphoma. In most cases, the lesions were incidental findings in reactive lymph nodes. The t(11;14) was detected in all eight cases examined. SOX11 was positive in seven of 16 cases (44%). Five cases were associated with other small B-cell lymphomas. In two cases, both SOX11-positive, the in situ mantle cell lymphoma lesions were discovered after the diagnosis of overt lymphoma; one 4 years earlier, and one 3 years later. Twelve of the remaining 15 patients had a follow-up of at least 1 year (median 2 years; range, 1-19.5), of whom 11 showed no evidence of progression, including seven who were not treated. Only one of 12 patients with an in situ mantle cell lymphoma lesion and no diagnosis of mantle cell lymphoma at the time developed an overt lymphoma, 4 years later; this case was also SOX11-positive. The six remaining cases were diagnosed as mantle cell lymphoma with a mantle zone pattern. Five were SOX11-positive and four of them were associated with lymphoma without a mantle zone pattern. ConclusionsIn situ mantle cell lymphoma lesions are usually an incidental finding with a very indolent behavior. These cases must be distinguished from mantle cell lymphoma with a mantle zone pattern and overt mantle cell lymphoma because they may not require therapeutic intervention.Key words: in situ mantle cell lymphoma, in situ involvement by mantle cell-lymphoma-like cells, indolent behavior. Citation: Carvajal-Cuenca

show abstract

Section: Discussionsupporting

confidence: 69%

In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior

Carvajal-Cuenca¹,

Sua²,

Silva³

et al. 2011

Haematologica

139

100

View full text Add to dashboard Cite

show abstract

“…[2][3][4]40 A staging workup may also be warranted to rule out the presence of overt lymphoma elsewhere. 35 Of note, a small (<1%) monoclonal l light chainrestricted plasma cell population was also detected in our patient's bone marrow, consistent with his known MGUS. While it is tempting to speculate that this might be a facet of putative plasma cell differentiation by the MZL, this is clearly not the case given the light chain discordance.…”

Section: Dsupporting

confidence: 78%

Multifocal Mantle Cell Lymphoma In Situ in the Setting of a Composite Lymphoma

Sloan

Xiong

Crivaro

et al. 2015

American Journal of Clinical Pathology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the availability of cyclin D1 antibodies with high sensitivity on paraffin-embedded tissues has led to the identification of rare cases of MCL either with minimal involvement of lymphatic tissues or unexpected growth patterns [6,7,9]. The two cases presented here show a very unusual "homing" to germinal centers with sparing of mantle zones and interfollicular areas, as opposed to conventional patterns of partial involvement by MCL.…”

Section: Discussionmentioning

confidence: 77%

“…Similarly, in a very recent case report [9], the presence of scattered MCL cells limited to reactive germinal centers of a morphologically hyperplastic-appearing lymph node was described and interpreted as a novel "follicular in situ" growth pattern of MCL. In this case, scattered cyclin D1-positive B cells were identified retrospectively in a staging lymph node for colonic adenocarcinoma resected 4 years before the diagnosis of symptomatic MCL.…”

Section: Discussionmentioning

confidence: 82%

Mantle cell lymphoma with intrafollicular growth pattern

et al. 2012

View full text Add to dashboard Cite

Mantle cell lymphoma (MCL) can show diffuse, nodular and mantle zone growth patterns. We report on two cases of MCL with an unusual intrafollicular growth pattern and discuss the differential diagnosis. The first case was a small lymph node biopsy from a patient with a history of MCL in remission for 6 years. The lymph node showed a preserved architecture but with cyclin D1-positive cells exclusively confined to follicle centers, thus representing an unusual in situ pattern of recurrent disease. The second case was a lymph node biopsy infiltrated with classical diffuse MCL but with areas of intrafollicular growth pattern. Both cases exhibited the classical immunophenotype of MCL with CD20 positivity and co-expression of CD5, cyclin D1, BCL2, and SOX11. Proliferation rate, as assessed by Mib-1 immunostaining was <10% within the infiltrated follicle centers. Fluorescence in situ hybridization analysis demonstrated a break in the CCND1 locus indicative of the t (11;14)(q13;q32), whereas the BCL2 gene locus was intact. Both patients followed a relatively indolent clinical course as compared with classical MCL. It is important to recognize this particular pattern in MCL, since it may occur as minimal lymph node involvement and may also lead to confusion with follicular lymphoma.

show abstract

Early Lymph Node Involvement by Mantle Cell Lymphoma Limited to the Germinal Center

Cited by 17 publications

References 19 publications

In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior

In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior

Multifocal Mantle Cell Lymphoma In Situ in the Setting of a Composite Lymphoma

Mantle cell lymphoma with intrafollicular growth pattern

Contact Info

Product

Resources

About