Early lung cancer detection based on registered perfusion MRI

Abstract

Abstract. Lung cancer remains the most common fatal malignancy in both men and women in the United States and elsewhere around the world among people who have been exposed passively or actively to tobacco smoke. Technological advances have produced imaging modalities that are proving to be useful for the early detection of lung cancer. In the usual modes, computed tomography (CT) and magnetic resonance imaging (MRI) can identify suspicious lesions, but further work is needed to detect cancer in its early stage. Tumor angiogenesis assessed by perfusion-sensitive MRI is a promising method for early and accurate identification of lung cancer that avoids patient stress and the potential progression to a less treatable stage inherent in serial imaging. However, compensating for the respiratory and anatomical structure motion is a challenge. In order to use perfusion MRI in a signal imaging session to define metabolic and vascular characteristics of tumors, we present a novel affine registration method for perfusion MRI that can register points of interest by tracking image intensity changes around the target point. The registration results are used to generate accurate time intensity curves (TIC) of different regions of interest (ROI). The patterns of different TICs are mapped on the cancer and other structures. The method is computationally efficient and performs well in our perfusion MRI sequence analysis.

Overview: Computational analysis and decision support systems in oncology

“…Huang et al discuss the assessment of tumor angiogenesis by perfusion-sensitive MRI, a method for early and accurate identification of lung cancer (19). Compensating for the motion of respiratory and anatomical structures is a challenge in this method.…”

Perfusion magnetic resonance imaging provides additional information as compared to anatomical imaging for decision-making in vestibular schwannoma

“…A tumour with a volume larger than 2 mm 3 is dependent on angiogenesis for growth, since the tumour growth critically depends on influx of oxygen and nutrients [12] , [13] . Perfusion MRI has been used for early detection and staging of many different tumour types, such as lung cancer and gliomas, although its added value for VS is yet unknown [14] , [15] .…”

Composite MR contrast agents for conditional cell‐labeling

“…The gadolinium chelate, gadopentetate dimeglumine (Gd-DTPA; Magnevist, Berlex Inc., Montville, NJ), which primarily shortens T 1 relaxation, has been used for the detection of various types of tumor (Huang et al, 2006;Rosen et al, 2003) as well as brain lesions associated with multiple sclerosis (Martino et al, 2002). On the other hand, the ultrasmall superparamagnetic iron oxide (SPIO) contrast agent, ferumoxides injectable solution (Feridex, Berlex Inc.-hereafter referred to SPIO) is another class of contrast agent that is clinically used to detect alterations in the reticuloendothelial system (RES) associated with hepatic tumors (Kanematsu et al, 2001) or to detect primary site or nodal metastases of various tumors (Mack et al, 2002;Bellin and Roy, 2007).…”