Early life trauma predicts self-reported levels of depressive and anxiety symptoms in nonclinical community adults: Relative contributions of early life stressor types and adult trauma exposure

Chu, Denise A.; Williams, Leanne M.; Harris, Anthony; Bryant, Richard A.; Gatt, Justine M.

doi:10.1016/j.jpsychires.2012.08.006

Cited by 100 publications

(75 citation statements)

References 59 publications

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“…The mechanism by which childhood adversity influences alcohol use during pregnancy is not clear, but the cumulative impact of ACEs can disrupt neurocognitive development during formative years (Anda et al, 2006; Teicher, Andersen, Polcari, Anderson, Navalta & Kim, 2003), limiting a person’s ability to cope with ongoing stressors (Dube et al, 2006), and increasing reactivity to stress during adulthood (Chu et al, 2013; Dong et al, 2004; Heim & Nemeroff, 2001). The influence of ACEs on perceived stress (Nelson et al, 2010) and anxiety (Agrati et al, 2015; Buist, Gotman & Yonders, 2011) during pregnancy may contribute to use of alcohol as a coping mechanism (Choi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The Association between Adverse Childhood Experiences and Alcohol Use during Pregnancy in a Representative Sample of Adult Women

Frankenberger

Clements-Nolle

Wang

2015

Women's Health Issues

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Background The impact of adverse childhood experiences (ACEs) on adult alcohol consumption is well-established, but little is known about the association with alcohol use during pregnancy. Methods Using data from the 2010 Nevada Behavioral Risk Factor Surveillance System (BRFSS), we assessed the relationship between ACEs and alcohol use during pregnancy in a representative sample of 1,987 adult women. An established ACEs scale was used to assess a range of childhood physical, emotional, and sexual abuse and household dysfunction (range 0–8). Weighted logistic regression was used to assess the relationship between ACE scores and alcohol use during pregnancy after controlling for drinking before pregnancy and other covariates. Results Six percent of participants reported drinking alcohol during pregnancy. After controlling for race/ethnicity, age, employment status, smoking status, and pre-pregnancy alcohol use, increasing ACEs were positively associated with higher odds of alcohol use during pregnancy (1 ACE: AOR= 2.92; 95% CI= 1.08, 7.87), (2–3 ACEs: AOR=3.52; 95% CI=1.46, 8.48), and (4 or more ACEs: AOR= 4.79; 95% CI=2.14, 10.72). Pre-pregnancy drinking was also strongly associated with alcohol use during pregnancy (AOR= 11.95; 95% CI=5.02, 28.43). Conclusions We found evidence of a dose-response relationship between ACEs and alcohol use during pregnancy that remained even after controlling for pre-pregnancy drinking and other covariates. Screening women of childbearing age as well as pregnant women for ACEs may be an effective way to identify and address many of the emotional, behavioral, and physical sequelae of childhood adversity.

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Section: Discussionmentioning

confidence: 99%

The Association between Adverse Childhood Experiences and Alcohol Use during Pregnancy in a Representative Sample of Adult Women

Frankenberger

Clements-Nolle

Wang

2015

Women's Health Issues

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“…Next, 25 studies also utilized primarily adult samples. Eight of the studies with primarily adult samples (Chu, Williams, Harris, Bryant, & Gatt, 2013;Jaycox, Marshall, & Orlando, 2003;Margolin, Vickerman, Oliver, & Gordis, 2010;Margolin et al, 2009;Marshall & Orlando, 2002;Scarpa & Fikretoglu, 2000;Scarpa & Ollendick, 2003;Walling et al, 2011) did not report any psychometric data concerning the measurement of exposure to community violence, and one study (Miller, Grabell, Thomas, Bermann, & GrahamBermann, 2012) only included mothers' perceptions of their children's violence exposure. The remaining 17 studies with primarily adult samples and which included psychometric data were included in the present review of measures.…”

Section: Methodsmentioning

confidence: 99%

Assessing Adult Exposure to Community Violence

DeCou

Lynch

2016

Trauma, Violence, & Abuse

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Although multiple measures demonstrated limited but acceptable psychometric performance in select studies, few in-depth psychometric analyses exist for measures of adult exposure to community violence. Also, it is difficult to compare studies due to variations in definitions of community violence and multiple versions of each measure. Recommendations for future research include provision of explicit definitions of community violence and reporting psychometric data for measures.

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“…Moreover, it has been shown that even children who do not go on to develop adult psychopathology may suffer long-term consequences of childhood maltreatment. In non-clinical samples of adults, individuals with a history of ACEs often report greater psychological distress, emotional reactivity, and sensitivity to stress than those without this history (Chu et al 2013; Edwards et al 2003; Glaser et al 2006; Hyman et al 2007; Marx and Sloan. 2003).…”

Section: Introductionmentioning

confidence: 99%

History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

et al. 2014

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Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, persons with a history of significant childhood adversity seem to experience greater psychological distress than those without this history. Evidence from rodent studies suggests that early life stress may impair dopamine function in ways that increase risks for drug abuse. However, the degree to which these findings translate to other species remains unclear. This study was conducted to examine associations between childhood adversity and dopamine and subjective responses to amphetamine in humans. Following intake assessment, 28 healthy male and female adults, ages 18–29 years, underwent two consecutive 90-minute positron emission tomography (PET) studies with high specific activity [11C]raclopride. The first scan was preceded by intravenous saline; the second by amphetamine (AMPH 0.3 mg/kg). Consistent with prior literature, findings showed positive associations between childhood trauma and current levels of perceived stress. Moreover, greater number of traumatic events and higher levels of perceived stress were each associated with higher ventral striatal dopamine responses to AMPH. Findings of mediation analyses further showed that a portion of the relationship between childhood trauma and dopamine release may be mediated by perceived stress. Overall, results are consistent with preclinical findings suggesting that early trauma may lead to enhanced sensitivity to psychostimulants and that this mechanism may underlie increased vulnerability for drug abuse.

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Early life trauma predicts self-reported levels of depressive and anxiety symptoms in nonclinical community adults: Relative contributions of early life stressor types and adult trauma exposure

Cited by 100 publications

References 59 publications

The Association between Adverse Childhood Experiences and Alcohol Use during Pregnancy in a Representative Sample of Adult Women

The Association between Adverse Childhood Experiences and Alcohol Use during Pregnancy in a Representative Sample of Adult Women

Assessing Adult Exposure to Community Violence

History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

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