Early life stress impairs brain and mental development during childhood increasing the risk of developing psychiatric disorders

Nakama, Nanako; Usui, Noriyoshi; Doi, Miyuki; Shimada, Shoichi

doi:10.1016/j.pnpbp.2023.110783

Cited by 9 publications

(2 citation statements)

References 79 publications

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“…Early-life stress (ELS) includes child maltreatment and the consequences of exposure to serious adverse events [149]. ELS contributes to the occurrence of a third of all mental disorders [150] and two thirds of all suicides [151], making it the most significant modifiable risk factor for psychiatric illness.…”

Section: Traumamentioning

confidence: 99%

Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction

Davidson,

Stevenson

2024

IJMS

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The hippocampus is a critical brain substrate for learning and memory; events that harm the hippocampus can seriously impair mental and behavioral functioning. Hippocampal pathophysiologies have been identified as potential causes and effects of a remarkably diverse array of medical diseases, psychological disorders, and environmental sources of damage. It may be that the hippocampus is more vulnerable than other brain areas to insults that are related to these conditions. One purpose of this review is to assess the vulnerability of the hippocampus to the most prevalent types of insults in multiple biomedical domains (i.e., neuroactive pathogens, neurotoxins, neurological conditions, trauma, aging, neurodegenerative disease, acquired brain injury, mental health conditions, endocrine disorders, developmental disabilities, nutrition) and to evaluate whether these insults affect the hippocampus first and more prominently compared to other brain loci. A second purpose is to consider the role of hippocampal blood–brain barrier (BBB) breakdown in either causing or worsening the harmful effects of each insult. Recent research suggests that the hippocampal BBB is more fragile compared to other brain areas and may also be more prone to the disruption of the transport mechanisms that act to maintain the internal milieu. Moreover, a compromised BBB could be a factor that is common to many different types of insults. Our analysis indicates that the hippocampus is more vulnerable to insults compared to other parts of the brain, and that developing interventions that protect the hippocampal BBB may help to prevent or ameliorate the harmful effects of many insults on memory and cognition.

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Section: Traumamentioning

confidence: 99%

Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction

Davidson,

Stevenson

2024

IJMS

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“…Studies indicate the potential mediating effect of Early Life Stress (ELS) on the relationship between borderline personality disorder and impairments in the ability to mentalize [95]. It is postulated that ELS, comprehended as stressful and adverse experiences in the period from fetal life to childhood, contributes to the development of numerous mental disorders, including borderline personality disorder [96,97]. Research demonstrates that ELS predominantly negatively influences cognitive brain networks (including those based on the hippocampus and prefrontal cortex) and a network involved in social behaviors [98][99][100].…”

Section: Mentalizing and Borderline Personality Disordermentioning

confidence: 99%

Mentalizing in Adolescents with Borderline Personality Disorder

Uzar,

Dmitrzak-Węglarz,

Słopień

2023

Brain Sciences

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Mentalizing, recognized as the capacity to understand behaviors in the context of our own mental states and those of other people, is being researched more and more commonly in regard to various mental disorders. The research on mentalization focuses on, among other things, borderline personality disorder, which is at present perceived as an emerging problem in the population of adolescents. In order to summarize the currently accessible knowledge of mentalizing in adolescents with borderline personality disorder, we thoroughly analyzed relevant publications. Based on the available literature, it can be concluded that the mentalizing ability of adolescents with borderline personality disorder can be impaired. The evidence demonstrates that they are prone to hypermentalizing, defined as an overattribution of mental states to other people. However, this tendency has not been proven to be specific to teenagers with this disorder. Moreover, the existing data suggest that young people with borderline personality exhibit a reduced capacity to mentalize their own inner states.

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Postweaning stress affects behavior, brain and gut microbiota of adolescent mice in a sex-dependent manner

Yin,

Zhao,

Wang

et al. 2024

Neuropharmacology

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Early life stress impairs brain and mental development during childhood increasing the risk of developing psychiatric disorders

Cited by 9 publications

References 79 publications

Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction

Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction

Mentalizing in Adolescents with Borderline Personality Disorder

Postweaning stress affects behavior, brain and gut microbiota of adolescent mice in a sex-dependent manner

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