Early life stress and the programming of eating behavior and anxiety: Sex-specific relationships with serotonergic activity and hypothalamic neuropeptides

Lima, Randriely Merscher Sobreira de; Bento, Lucas Victor dos Santos; Lugon, Magda Delorence; Baraúna, Valério Garrone; Bittencourt, Athelson Stefanon; Dalmaz, Carla; Bittencourt, Ana Paula Santana de Vasconcellos

doi:10.1016/j.bbr.2019.112399

Cited by 38 publications

(26 citation statements)

References 86 publications

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“…Indeed, studies on animals show that stress due to maternal separation has been associated with modifications in fear regulation (e.g., an increased risk of developing anxiety, a higher consumption of palatable food). Remarkably, male rat offspring were more vulnerable than females to the effects of neonatal stress on anxiety-like behavior, as well as on food consumption [ 24 , 25 ]. Stress due to early life exposure to food pesticides (even at low dosage) in animals can modify neuronal development, leading to progressive neurodegeneration in adulthood.…”

Section: Epigenetic Programming During the First 1000 Days Of Lifementioning

confidence: 99%

Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

Gabbianelli

Bordoni

Morano

et al. 2020

IJMS

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Maternal lifestyle is an important factor in the programming of an infant’s epigenome, in particular when considered alongside the mode of birth and choice of feeding method (i.e., breastfeeding or formula feeding). Beginning in utero, and during the first two years of an infant’s life, cells acquire an epigenetic memory of the neonatal exposome which can be influential across the entire lifespan. Parental lifestyle (e.g., malnutrition, alcohol intake, smoke, stress, exposure to xenobiotics and/or drugs) can modify both the maternal and paternal epigenome, leading to epigenetic inheritance in their offspring. This review aims to outline the origin of early life modulation of the epigenome, and to share this fundamental concept with all the health care professionals involved in the development and provision of care during childbirth in order to inform future parents and clinicians of the importance of the this process and the key role it plays in the programming of a child’s health.

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Section: Epigenetic Programming During the First 1000 Days Of Lifementioning

confidence: 99%

Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

Gabbianelli

Bordoni

Morano

et al. 2020

IJMS

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“…The impairments of the homeostasis of the serotonergic system are associated with disorders of eating behavior, usually associated with increased food intake, either by homeostatic or hedonic changes. In particular, the serotonergic system appears extremely sensitive to environmental changes during the development of the organism, and several studies have shown that ELS impairs the function of the 5HT system (de Lima et al, 2020).…”

Section: Serotonin: Role On Feeding Behavior Influences Of Els and mentioning

confidence: 99%

“…In middle aged females, it increases the 5HT1B gene expression in the hypothalamus, associated with decreased food intake ( de Souza et al, 2020a ), and in adult males, we observed a decreased action of fluoxetine on food intake ( de Souza et al, 2020b ). In addition, MS promotes decreased 5HT concentration in hypothalamus and amygdala of young animals, associated with increased palatable food intake ( de Lima et al, 2020 ). Together, these data suggest that MS alter the serotonergic system function, contributing to disorders of feeding behavior.…”

Section: Serotonin: Role On Feeding Behavior Influences Of Els and mentioning

confidence: 99%

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

2020

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“…Notably, these anxiety-related mood changes may affect the growth and development of the pups and their weight gain (45,46). Contradictory findings have been reported about the effect that exposure to MS has on body weight, certain studies found that the body weight in pups was lower in adulthood, while other studies found no differences between stressed and control animals (47).…”

Section: Discussionmentioning

confidence: 99%

Effects of BDNF Signaling on Anxiety-Related Behavior and Spatial Memory of Adolescent Rats in Different Length of Maternal Separation

Zhang

Sun

et al. 2020

Front. Psychiatry

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As an adverse form of early-life stress (ELS), maternal separation (MS) can interfere with the development of cognition and behaviors of adolescent rodents. Brain-derived neurotrophic factor (BDNF) is involved in the regulation of brain development and function, but the molecular mechanisms by which BDNF regulates brain function and behavior in MS with different stressor strengths remain unclear. This descriptive study characterized the levels of BDNF in the prefrontal cortex (PFC) and plasma corticosterone (CORT) from the offspring of rats exposed to early handling (EH, 15-min separation per day) and prolonged MS (PMS, 180-min separation per day), during postnatal days (PND) 1-21. The behavioral and biochemical analyses were performed during adolescence (PND 42-56). PMS resulted in reduced weight and decreased locomotor activity in the open field test and Y-maze task compared to control (CON) group, with EH showing an intermediate phenotype. BDNF protein levels in the PFC were lower in PMS compared to EH and further reduced in CON male rats. Plasma CORT levels were higher in PMS compared to CON with EH again showing intermediate levels. Neither PMS or EH affected spatial learning in the Y-maze task. These findings indicate that longer periods of maternal separation are necessary to increase anxiety-like behavior, elevate CORT levels, and further suppress BDNF levels in the PFC, providing a possible mechanism to explain why more severe forms of ELS lead to more significant psychiatric and medical consequences later in life.

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Early life stress and the programming of eating behavior and anxiety: Sex-specific relationships with serotonergic activity and hypothalamic neuropeptides

Cited by 38 publications

References 86 publications

Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

Early Life Stress and the Onset of Obesity: Proof of MicroRNAs’ Involvement Through Modulation of Serotonin and Dopamine Systems’ Homeostasis

Effects of BDNF Signaling on Anxiety-Related Behavior and Spatial Memory of Adolescent Rats in Different Length of Maternal Separation

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