Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei

Cohen, Ronald A.; Grieve, Stuart M.; Hoth, Karin F.; Paul, Robert; Sweet, Lawrence H.; Tate, David F.; Gunstad, John; Stroud, Laura R.; McCaffery, Jeanne M.; Hitsman, Brian; Niaura, Raymond; Clark, Christopher; MacFarlane, Alexander C.; Bryant, Richard A.; Gordon, Evian; Williams, Leanne M.

doi:10.1016/j.biopsych.2005.12.016

Cited by 384 publications

(350 citation statements)

References 104 publications

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“…Stronger correlation of depressive symptoms and rACC volume in boys with a positive family history of depression may be mediated by stress-induced morphologic changes that accompany the experience of having a care-giver or loved one suffer from depression. In line with this hypothesis, a study of ACC volume in adults has shown an inverse correlation with number of stressful or traumatic adverse childhood events (50). There is also a mechanism in place to explain how environmental stressors may alter ACC anatomy; stress induces the release of glucocorticoids, which have been shown to mediate structural alterations of the medial prefrontal cortex (51)(52)(53).…”

Section: Discussionmentioning

confidence: 95%

Rostral Anterior Cingulate Cortex Volume Correlates with Depressed Mood in Normal Healthy Children

Boes¹,

McCormick²,

Coryell³

et al. 2008

Biological Psychiatry

129

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BACKGROUND-The rostral anterior cingulate cortex (rACC) has been implicated as a structural neural correlate of familial major depressive disorder, raising the possibility that the structure of this region may act as a biologic marker of depression vulnerability. The aim of the current study was to determine whether children and adolescents with depressive symptoms have lower rACC volume relative to those without symptoms and examine how a positive family history of depression affects this relationship.

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Section: Discussionmentioning

confidence: 95%

Rostral Anterior Cingulate Cortex Volume Correlates with Depressed Mood in Normal Healthy Children

Boes¹,

McCormick²,

Coryell³

et al. 2008

Biological Psychiatry

129

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“…Previous findings suggest that low SES is associated with reduced activation in the insula and ACC (Silverman et al, 2009). In addition, healthy adults with a history of adverse childhood events exhibit reduced ACC volume (Cohen et al, 2006). Thus, we predicted that individuals from low-income backgrounds would exhibit alterations in SN connectivity.…”

Section: Discussionmentioning

confidence: 99%

“…Lower childhood SES has been linked to reduced hippocampal volume both during childhood (Hanson et al, 2011) and into adulthood (Staff et al, 2012). Lower early-life SES is also associated with reduced anterior cingulate cortex (ACC) and caudate volume in adults (Cohen et al, 2006). The effects of SES have also been demonstrated in brain activation studies.…”

Section: Introductionmentioning

confidence: 99%

Childhood Poverty and Stress Reactivity Are Associated with Aberrant Functional Connectivity in Default Mode Network

Sripada¹,

Swain

Evans

et al. 2014

Neuropsychopharmacol

136

116

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Convergent research suggests that childhood poverty is associated with perturbation in the stress response system. This might extend to aberrations in the connectivity of large-scale brain networks, which subserve key cognitive and emotional functions. Resting-state brain activity was measured in adults with a documented history of childhood poverty (n ¼ 26) and matched controls from middle-income families (n ¼ 26). Participants also underwent a standard laboratory social stress test and provided saliva samples for cortisol assay. Childhood poverty was associated with reduced default mode network (DMN) connectivity. This, in turn, was associated with higher cortisol levels in anticipation of social stress. These results suggest a possible brain basis for exaggerated stress sensitivity in low-income individuals. Alterations in DMN may be associated with less efficient cognitive processing or greater risk for development of stress-related psychopathology among individuals who experienced the adversity of chronic childhood poverty.

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“…Early life stress has also frequently been associated with structural brain alterations, particularly in those brain areas that mature late, such as the hippocampus and prefrontal cortex (PFC) (2)(3)(4). Such structural brain alterations may be caused by a lack of neurotrophic factors, whose synthesis is reduced in the aftermath of stress (5).…”

Section: Introductionmentioning

confidence: 99%

BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects

et al. 2011

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Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei

Cited by 384 publications

References 104 publications

Rostral Anterior Cingulate Cortex Volume Correlates with Depressed Mood in Normal Healthy Children

Rostral Anterior Cingulate Cortex Volume Correlates with Depressed Mood in Normal Healthy Children

Childhood Poverty and Stress Reactivity Are Associated with Aberrant Functional Connectivity in Default Mode Network

BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects

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