Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes

Austin, Makeda K.; Chen, Eric; Ross, Kharah M.; McEwen, Lisa M.; Maclsaac, Julia L.; Kobor, Michæl S.; Miller, Gregory E.

doi:10.1016/j.psyneuen.2018.07.007

Cited by 81 publications

(72 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We describe a positive DNAm age residual as DNAm AA and a negative residual as DNAm age deceleration. Most studies of ACE and DNAm AA use the Horvath, rather than Hannum, epigenetic clock [11][12][13][14]17]. The Horvath method has been validated in different tissue types and in samples from children and adults [42], whereas the Hannum clock was developed using adult whole blood samples [5].…”

Section: Methodsmentioning

confidence: 99%

“…"Epigenetic clocks," which are sets of DNA methylation (DNAm) markers (CpG sites) that accurately predict chronological aging, have been recently described [4][5][6], and higher DNAm-predicted age relative to chronological age [DNAm age acceleration (AA)] is associated with cardiovascular disease [7], cancer [8], lower verbal fluency [9], and all-cause mortality [10]. DNAm AA has also been associated with childhood exposure to adversity, including parental depression [11], violence [12,13], sexual abuse [14], low socioeconomic status [15][16][17], and cumulative exposure to sexual abuse, physical abuse, or neglect [18].…”

Section: (Continued From Previous Page)mentioning

confidence: 99%

See 1 more Smart Citation

Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

et al. 2020

View full text Add to dashboard Cite

Background: Epigenetic mechanisms may partly explain the persistent effects of adverse childhood experiences (ACEs) on health outcomes in later life. DNA methylation can predict chronological age, and advanced methylationpredicted age beyond chronological age (DNA methylation age acceleration) is associated with ACEs, adverse mental and physical health, and elevated diurnal and baseline salivary cortisol. Childhood adversity is also associated with dysregulation of the hypothalamic-pituitary-adrenal axis, which produces the neuroendocrine hormone cortisol. It remains unknown whether these associations are specific to certain types of adversity. Herein, we investigate the associations of ACEs with DNA methylation age acceleration and plasma cortisol in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. Methods: In this study of the children in ALSPAC, we used multiple linear regression to examine associations of cumulative exposure to ACE, as well as exposure to ten individual types of ACEs, with Horvath-estimated DNA methylation age acceleration and with baseline plasma cortisol. The ten ACEs were those included in the World Health Organization's ACE International Questionnaire. Data on ACEs were prospectively collected from age 0-14 years. DNA methylation age acceleration and plasma cortisol were measured at mean 17.1 years and 15.5 years, respectively.(Continued on next page)

show abstract

Section: Methodsmentioning

confidence: 99%

Section: (Continued From Previous Page)mentioning

confidence: 99%

Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although this assumption is widespread in the literature, including for epigenetic clock analyses [34, 35], our results are broadly consistent with empirical results in humans. Specifically, while studies of early life adversity, which also predicts lifespan in human populations, find relatively consistent support for a relationship between early adversity and accelerated epigenetic aging in children and adolescents [36–41], there is little evidence for the long-term effects of early adversity on epigenetic age in adulthood [42–47]. Thus, while DNA methylation may make an important contribution to the biological embedding of early adversity into adulthood [48, 49], it does not seem to do so through affecting the epigenetic clock itself.…”

Section: Resultsmentioning

confidence: 99%

The costs of competition: high social status males experience accelerated epigenetic aging in wild baboons

Anderson

Johnston

Lea

et al. 2020

Preprint

View full text Add to dashboard Cite

25Aging, for virtually all life, is inescapable. However, within species and populations, 26 rates of biological aging (i.e., physical decline with age) vary across individuals. 27Understanding sources of variation in biological aging is therefore central to understanding 28 the biodemography of natural populations. Here, we constructed a DNA methylation-based 29 predictor of chronological age for a population of wild baboons in which behavioral, 30 ecological, and life history data have been collected for almost 50 years (N = 277 blood 31 samples from 245 individuals, including 30 who were longitudinally sampled). Consistent 32 with findings in humans and model organisms [1][2][3][4], DNA methylation patterns exhibit a 33 strong, clock-like association with chronological age, but individuals are often predicted to 34 be somewhat older or younger than their known age. However, the two most robust 35 predictors of lifespan described for this population-cumulative early adversity and social 36bond strength-do not explain this deviation. Instead, the single most predictive factor is 37 male dominance rank: high-ranking males are predicted to be biologically older than their 38 true chronological age, such that alpha males appear to be nearly a year older than their 39 known age. Longitudinal sampling indicates that males who climb the social hierarchy 40 subsequently look epigenetically "older," likely reflecting the high energetic costs of rank 41 attainment and maintenance in male baboons. Together, our results indicate that 42 environmental effects on survival and epigenetic age can be disjunct, and that achieving 43high rank for male baboons-the best predictor of reproductive success-imposes 44 physiological costs consistent with a "live fast, die young" life history strategy. 45 46

show abstract

“…This mode of protection is typically lost when maternally derived antibodies are degraded, but the maturing offspring immune system's ability to generate its own effective adaptive immunity replaces it [56]. A wide body of research highlights the fundamental role early-life environment plays in determining the broad transcriptional identity of circulating lymphocytes and showing that the early-life environment has a very strong influence on T-cells [57][58][59][60][61][62].…”

Section: Maternal Pre-conception Environment and Long Lasting Influenmentioning

confidence: 99%

Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models

et al. 2018

View full text Add to dashboard Cite

Intrauterine and early life has been accepted as important susceptibility windows for environmental exposure and disease later in life. Emerging evidence suggests that exposure before conception may also influence health in future generations. There has been little research on human data to support this until now. This review gives evidence from epigenetic as well as immunologic research, and from animal as well as human models, supporting the hypothesis that there may be important susceptibility windows before conception in relation to exposure such as obesity, diet, smoking and infections. It is likely that we can identify vulnerability windows in men and women in which interventions may have an impact on several generations in addition to individual health. Establishing vulnerability windows affecting health over future generations, and not only in the now or the near future of the individual, may provide tremendous opportunities for health policy and practice.

show abstract

Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes

Cited by 81 publications

References 14 publications

Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study

The costs of competition: high social status males experience accelerated epigenetic aging in wild baboons

Environmental Impact on Health across Generations: Policy Meets Biology. A Review of Animal and Human Models

Contact Info

Product

Resources

About