Early-life Pb exposure as a potential risk factor for Alzheimer’s disease: are there hazards for the Mexican population?

Chin-Chan, Miguel; Cobos-Puc, Luis E.; Alvarado-Cruz, Isabel; Bayar, Melike; Ermolaeva, Maria A.

doi:10.1007/s00775-019-01739-1

Cited by 12 publications

(4 citation statements)

References 155 publications

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“…Exposure to Pb during the early stages after birth and continuous exposure from birth can increase the levels of Aβ and phospho-Tau in the hippocampi of mice, leading to poor learning and memory abilities. However, exposure to Pb in adulthood does not result in the same effects [17]. Lead enters the body and gets absorbed into cells and tissues.…”

Section: Leadmentioning

confidence: 99%

Metal toxicity exposure in Alzheimer's disease - literature review

Jakubowska,

Hoppe-Mitera,

Sionek

et al. 2024

J Educ Health Sport

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Introduction and purpose: As the elderly population grows, the risk of cognitive decline and dementia increases. Environmental toxicants, including metals, have been identified as potential contributors to these conditions. This literature review investigated the potential contribution of metals, such as aluminium, lead, zinc and copper to Alzheimer's disease development.Material and methods: The literature was conducted using "Pub Med" and "Google Scholar" databases with the keywords "metals", "Alzheimer's disease", "aluminium", "lead", "neurodegenerative diseases", "copper".Brief description of the state of knowledge: Metals can negatively affect the functionality of the central nervous system, leading to impairments in behavior, motor skills, and cognitive abilities. The development of Alzheimer's disease can be influenced by several factors, including Aβ aggregates, tau tangles, synaptic dysfunction, inflammation, and oxidative stress, which may be worsened by interactions with these metals.Results and conclusions: Extensive research has shown a link between metal exposure and neurodegeneration. Understanding the role of metals like lead, copper, aluminum, and zinc in Alzheimer's disease pathogenesis remains crucial, but further investigation is needed. A better insight into the impact of metal exposure on brain health could help find the way for effective prevention and treatment strategies for neurodegenerative diseases.

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Section: Leadmentioning

confidence: 99%

Metal toxicity exposure in Alzheimer's disease - literature review

Jakubowska,

Hoppe-Mitera,

Sionek

et al. 2024

J Educ Health Sport

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show abstract

“…Indeed, evidence from studies conducted in zebrafish, rodent, and non-human primate models by Zawia's and other research groups has supported the proposition that developmental exposure to Pb can result in an increased risk of developing AD pathology later on in life. Importantly, developmental Pb can result in alterations (at protein and gene levels) of the major players involved in the regulation of both of the major pathogenic species of AD (amyloid-beta and hyperphosphorylated tau) [110][111][112][113][114][115][116][117][118][119][120][121][122].…”

Section: Neurobehavioral Effects Of Early-life Pb Exposurementioning

confidence: 99%

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Ahmad

Liu

2020

Antioxidants

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Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

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“…This was manifested by increasing AβPP, b-site AβPP cleaving enzyme (BACE), and Aβ and by decreasing DNA methyltransferase activity [16]. In an epidemiological review toward the Mexican population, it was summarized that early-life lead exposure was a potential risk factor for AD in the Mexican population [85]. While these mechanisms partly explained the key cellular and molecular changes brought by lead exposure, it is still pivotal to figure out the "fetal programming" phenomenon involved in the studied pathogenesis.…”

Section: Epigenetic Mechanisms Of Lead-induced Alzheimer's Diseasementioning

confidence: 99%

Epigenetics and Lead Neurotoxicity

Xu¹,

Zhang²

2020

Lead Chemistry

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Lead exposure continues to threaten human health in a worldwide perspective. Among the multiple target organs affected by lead, central nervous system (CNS) pervades in the adverse consequences by chronic lead exposure, leading to a variety of neurotoxic manifestations and neurological disorders. The epigenetic machinery plays a vital role in the control of key neural functions, particularly neuronal development. Faulty epigenetic gene regulation can have marked deleterious effect on the developing brain that can last for an entire lifespan. Mounting evidence suggests that lead exposure can pose detrimental effect on CNS through these epigenetic mechanisms. And this chapter reviews the current understandings of concrete epigenetic forms, exemplified by DNA methylation, histone modification, and ncRNAs, responding to lead exposure and moderating the consequent neurotoxicity. In addition, Alzheimer's disease (AD) is presented as a typical instance to explain how environmental lead exposure results in the occurrence of AD in an "early exposure, late onset" fashion. A future perspective, highlighting additional forms of epigenetic elements as well as interactive actions among different molecules, was also proposed. In summary, epigenetics was substantially implicated in regulating lead neurotoxicity.

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Early-life Pb exposure as a potential risk factor for Alzheimer’s disease: are there hazards for the Mexican population?

Cited by 12 publications

References 155 publications

Metal toxicity exposure in Alzheimer's disease - literature review

Metal toxicity exposure in Alzheimer's disease - literature review

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Epigenetics and Lead Neurotoxicity

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