Early life interventions metformin and trodusquemine metabolically reprogram the developing mouse liver through transcriptomic alterations
Sarah A. Ashiqueali,
Augusto Schneider,
Xiang Zhu
et al.
Abstract:Recent studies have demonstrated the remarkable potential of early life intervention strategies at influencing the course of postnatal development, thereby offering exciting possibilities for enhancing longevity and improving overall health. Metformin (MF), an FDA‐approved medication for type II diabetes mellitus, has recently gained attention for its promising anti‐aging properties, acting as a calorie restriction mimetic, and delaying precocious puberty. Additionally, trodusquemine (MSI‐1436), an investigati… Show more
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