Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice

Qian, Lijuan; Kang, Shumin; Xie, Jing; Huang, Li; Wen, Quan; Fan, Yuanyuan; Lu, Lijun; Jiang, Li

doi:10.1186/s12866-017-1044-0

Cited by 39 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cats with eosinophilic airway disease were younger (mean age, 4.4 years) than cats with mixed or neutrophilic inflammation, which is consistent with previous reports, 8,13,15,20 although only 1 other study found this finding to be statistically significant 15 . This tendency toward a younger age of onset parallels the development of asthma in humans, most commonly a childhood disease where the allergic or hypersensitivity response is related to specific development of neonatal and juvenile immunity 21‐23 . In neonatal murine models of asthma, increased diversity of lung or gut microbiota promotes a more favorable environment for tolerance against allergic disease by inducing T‐regulatory cells, lower concentrations of IgE and altered balance of Th1/Th2 immune responses 24‐26 .…”

Section: Discussionsupporting

confidence: 84%

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

Lee

Johnson

et al. 2020

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: Idiopathic inflammatory airway disease (IAD) in cats often is described as asthmatic (eosinophilic) or bronchitic (neutrophilic), but this designation requires collection of airway fluid and it fails to consider cats with mixed airway inflammation.Objective: To identify clinical features that would differentiate inflammatory disease types.Animals: Forty-nine cats with nonspecific airway inflammation identified by bronchoscopic bronchoalveolar lavage (BAL) between 2011 and 2018 were evaluated.Methods: This is a retrospective study. Cats were categorized by BAL differential cytology as having eosinophilic (eosinophils >20% with neutrophils <14%, or eosinophils >50%), mixed (eosinophils 20%-50% and neutrophils >14% or discordant inflammation from 2 BAL sites), or neutrophilic (neutrophils >14% and eosinophils <20%) inflammation. Type and duration of presenting complaints, signalment, body condition score, respiratory rate, CBC results, bronchoscopy, BAL results (% recovery, total nucleated cell count, differential cell count), and radiographic findings were compared among groups.Results: Idiopathic IAD was diagnosed in 49 cats, with BAL eosinophilic inflammation in 23, mixed inflammation in 14, and neutrophilic inflammation in 12. Cough was the predominant presenting complaint with no difference in duration of signs among groups (median, 5.5 months). Respiratory rate and effort also did not differ. Cats with eosinophilic inflammation were significantly younger (4.4 ± 3.3 years) than those with neutrophilic (8.0 ±5.6 years) or mixed inflammation (7.5 ± 4.0 years; P = .03). Results of CBC and interpretation of radiographic findings did not differ among groups.Conclusions and Clinical Importance: Substantial overlap exists in clinical and radiographic findings in cats with various forms of idiopathic airway inflammation.

show abstract

Section: Discussionsupporting

confidence: 84%

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

Lee

Johnson

et al. 2020

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Low total diversity of the gut microbiota of infant during the first month of life was associated with asthma development in children at 7 years old (Abrahamsson et al, 2014). The diversity of the gut microbial in early life may avoid airway inflammation in asthma via mediating the balance of Th1/Th2 (Qian et al, 2017).…”

Section: The Pathogenic Role Of Gut Microbiota In Common Lung Diseasementioning

confidence: 99%

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

et al. 2020

View full text Add to dashboard Cite

Emerging findings indicate there is a vital cross-talk between gut microbiota and the lungs, which is known as gut-lung axis. The gut disturbances in lung diseases including allergy, asthma, chronic obstructive pulmonary disease, cystic fibrosis and lung cancer were observed by extensive studies. Investigating how gut microbiota impact other distant organs is of great interest in recent years. Although it has not been fully understood whether the disturbance is the cause or effect of lung diseases, alterations in the gut microbial species and metabolites have been linked to changes in immune responses and inflammation as well as the disease development in the lungs. In this article, we systemically review the role and mechanisms underlying the changes in the constituent of gut microbiota and metabolites in lung diseases. In particular, the roles of gut-lung axis in mediating immune responses and reshaping inflammation are highlighted. Furthermore, we discuss the potential of strategies to manipulate the gut microbiota and metabolites as the therapeutic approach for lung diseases.

show abstract

“…Th2 cells promote resistance to extracellular pathogens and importantly to the current study, antagonize the production and activity of Th1 cytokines, including IFN-γ [ 4 , 5 ]. Thus, an altered Th1/Th2 balance can influence host susceptibility to a variety of immune-mediated diseases, including allergy, autoimmunity and increased infections [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of various radiation doses on induced T-helper cell differentiation and related cytokine secretion

Gao

Dong

Gong

et al. 2018

Journal of Radiation Research

View full text Add to dashboard Cite

Exposure to ionizing radiation often induces T helper (Th) cell differentiation, resulting in an imbalance of Th1 and Th2 cellular subtypes, which can affect the efficacy of cancer radiotherapy. The aim of this study was to analyze differential expression of Th1, Th2 and Th3/Type 1 regulatory T cell (Tr1) subtype–related genes and cytokines in mouse thymocytes after high- and low-dose systemic radiation, using functional classification gene arrays and Elisa assays, and to explore the molecular mechanisms underlying radiation’s immune effects and their relationship with Th1/Th2 immunity. We found that expression of 8 genes was upregulated after LDR, while expression of 5 genes was downregulated. After HDR, 54 genes were upregulated and 3 genes were downregulated, including genes related to Th1, Th2 and Th3/Tr1 cellular subtypes, Th1/Th2-type immune response genes and transcription factor–related genes. In the foregoing results, LDR and HDR in the thymus induced opposite patterns of expression for Th1-, Th2- and Th3-type related cytokines TGF-β, C/EBP-β and TNF-α. We also found that expression of Interferon-γ (IFN-γ) and Interleukin-2 (IL-2), which have a moderating effect on immune function, was upregulated after LDR. Furthermore, the secretion of negative regulatory factors Interleukin-1β (IL-1β), Interleukin-4 (IL-4), transforming growth factor-β (TGF-β) and Interleukin-21 (IL-21) was reduced after LDR, but HDR produced the opposite effect and stimulated their expression. These findings suggest that LDR may induce a Th1-type immune response, while HDR may lead to a Th2-type immune response.

show abstract

Early-life gut microbial colonization shapes Th1/Th2 balance in asthma model in BALB/c mice

Cited by 39 publications

References 30 publications

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

The Cross-Talk Between Gut Microbiota and Lungs in Common Lung Diseases

Effects of various radiation doses on induced T-helper cell differentiation and related cytokine secretion

Contact Info

Product

Resources

About