Early Life Factors Influencing the Risk of Obesity

Lifschitz, Carlos

doi:10.5223/pghn.2015.18.4.217

Cited by 15 publications

(10 citation statements)

References 38 publications

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“…We found that girls with AWG between 6 and 15 months of age had shorter exclusive and total breastfeeding times than did their peers. Our results were in accordance with the previous studies in which infant formulas were proposed to predispose them to AWG in infancy (38). In a recent study, Kale et al (39) reported that girls who were mixed-fed or predominantly breastfed had later onset of breast development than formula-fed girls, and that the duration of breastfeeding was directly related to the age at onset of breast development.…”

Section: Discussionsupporting

confidence: 93%

The relationship between infancy growth rate and the onset of puberty in both genders

Aydın

Devecioğlu

Kadıoğlu³

et al. 2017

Pediatr Res

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BackgroundIn this study, we examined the hypothesis that weight gain and linear growth during the first years of life influence the onset of puberty both in girls and in boys.MethodsA cohort of 157 healthy children, aged 6-9 years, was evaluated and their growth patterns were analyzed retrospectively. Repeated measures mixed model was used to examine the longitudinal anthropometric data.ResultsGirls with pubertal signs were heavier than their peers starting at 9 months of age (P=0.02), and the difference became more evident over time (P<0.001). Accelerated weight gain between 6 and 15 months of age was found to increase the odds of having a pubertal sign at the study visit (odds ratio (OR)=34.5) after adjusting for birth weight, gestational age and current age, height, weight, and BMI (P=0.004). Anthropometric indices of boys with or without pubertal signs were not significantly different at the study visit, but boys with accelerated height gain between 9 and 15 months of age were more likely to have pubertal signs (OR=15.8) after adjusting for birth weight, gestational age and current age, height, weight, and BMI (P=0.016).ConclusionEarly growth acceleration might be important for the timing of puberty in both genders.

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Section: Discussionsupporting

confidence: 93%

The relationship between infancy growth rate and the onset of puberty in both genders

Aydın

Devecioğlu

Kadıoğlu³

et al. 2017

Pediatr Res

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“… 1 , 3 Childhood obesity may persist into adulthood, thereby contributing to widespread cardiometabolic comorbidities. 4–6 Beyond maternal obesity, 7 , 8 socioeconomic status, 9 , 10 and early life nutrition, 7 , 11–13 emerging evidence indicates that the infant gut microbiota may influence growth trajectories in the first year of life, 14–17 which may in turn predict future obesity. 3 , 18 , 19 Given that rapid infant growth is a potential determinant of overweight/obesity in school-age children, 20 the developing gut microbiota may be an important predictor for rapid infant growth and childhood obesity.…”

Section: Introductionmentioning

confidence: 99%

Early life gut microbiota is associated with rapid infant growth in Hispanics from Southern California

et al. 2021

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We aimed to determine if the newborn gut microbiota is an underlying determinant of early life growth trajectories. 132 Hispanic infants were recruited at 1-month postpartum. The infant gut microbiome was characterized using 16S rRNA amplicon sequencing. Rapid infant growth was defined as a weight-for-age z-score (WAZ) change greater than 0.67 between birth and 12-months of age. Measures of infant growth included change in WAZ, weight-for-length z-score (WLZ), and body mass index (BMI) z-scores from birth to 12-months and infant anthropometrics at 12-months (weight, skinfold thickness). Of the 132 infants, 40% had rapid growth in the first year of life. Multiple metrics of alpha-diversity predicted rapid infant growth, including a higher Shannon diversity (OR = 1.83; 95% CI: 1.07–3.29; p = .03), Faith’s phylogenic diversity (OR = 1.41, 95% CI: 1.05–1.94; p = .03), and richness (OR = 1.04, 95% CI: 1.01–1.08; p = .02). Many of these alpha-diversity metrics were also positively associated with increases in WAZ, WLZ, and BMI z-scores from birth to 12-months (p all <0.05). Importantly, we identified subsets of microbial consortia whose abundance were correlated with these same measures of infant growth. We also found that rapid growers were enriched in multiple taxa belonging to genera such as Acinetobacter, Collinsella, Enterococcus, Neisseria , and Parabacteroides . Moreover, measures of the newborn gut microbiota explained up to an additional 5% of the variance in rapid growth beyond known clinical predictors (R 2 = 0.37 vs. 0.32, p < .01). These findings indicate that a more mature gut microbiota, characterized by increased alpha-diversity, at as early as 1-month of age, may influence infant growth trajectories in the first year of life.

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“…Obesity may track throughout the life course and is associated with a myriad of conditions, including cardiovascular disease, type 2 diabetes, metabolic syndrome, joint problems, reduced life expectancy, and poorer psychological state . Obesity is a multifaceted disorder with an interplay among genetic, dietary, and hormonal factors contributing to its development early in life . As such, exposures during infancy may program metabolic health later in life, and prevention efforts could begin early.…”

Section: Introductionmentioning

confidence: 99%