Early-life exposure to the Chinese famine and risk of hyperuricaemia in adult females in Qingdao

Shao, Yu-Han; Liu, Li; Li, Xiaojing; Sun, Jianping; Huang, Xiaomei

doi:10.1017/s0007114521002749

Cited by 4 publications

(5 citation statements)

References 44 publications

(49 reference statements)

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“…Zhang et al ( 26 ) found that exposure to Chinese famine during fetal, childhood, and adolescence was associated with a higher chance of having hyperuricemia in the hypertensive population. Shao et al ( 27 ) provided interesting findings regarding the association between famine exposure and hyperuricemia. According to their results, women exposed to Chinese famine during childhood and adolescence was associated with an increased risk of hyperuricemia, while no significant association was observed during the fetal period.…”

Section: Discussionmentioning

confidence: 99%

“…Participants who underwent malnutrition may exhibit impaired kidney function and reduced uric acid excretion in later life ( 17 ). Furthermore, malnutrition activates the hypothalamic-pituitary-adrenal axis ( 44 ), leading to an excessive production of uric acid ( 27 ). Women exposed to prolonged food shortages during critical periods of growth and development may experience a reduction in the secretion of gonadotropin-releasing hormone, significantly impacting their metabolic abilities.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to Chinese famine and the risk of hyperuricemia in later life: a population-based cross-sectional study

Xiong,

Liu,

Tang

et al. 2024

Front. Nutr.

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BackgroundLimited studies have investigated the relationship between famine exposure and the risk of hyperuricemia in later life. Consequently, the primary purpose of the current study was to examine the potential association between exposure to Chinese famine and hyperuricemia, as well as any gender disparities in this relationship.MethodThe data were obtained from the China PEACE (China Patient-Centered Evaluative Assessment of Cardiac Events) Million Persons Project in Rongchang. The study participants were enrolled into different cohorts based on their birthdates: the fetal-exposed cohort (born between 1959 and 1962), the childhood-exposed cohort (born between 1949 and 1958), the adolescence-exposed cohort (born between 1941 and 1948), and the non-exposed cohorts (born between 1963 and 1974). The potential association between famine exposure and hyperuricemia was assessed using binary logistic regression models.ResultsA total of 6,916 individuals were enrolled in the current study with an average age of 60.11 ± 9.22 years, out of which 3,544 were women. After adjusting for confounding factors, fetal (OR = 0.530, 95% CI: 0.411–0.0.683), childhood (OR = 0.642, 95% CI: 0.494–0.833) exposure to the Chinese famine for men was negatively associated with hyperuricemia. Conversely, exposure to the Chinese famine during fetal (OR = 2.144, 95% CI: 1.622–2.834), childhood (OR = 1.485, 95% CI: 1.105–1.997), and adolescence (OR = 1.967, 95% CI: 1.465–2.641) for women was positively associated with hyperuricemia. Furthermore, the impact of famine on hyperuricemia that has been observed in exposed women might be intensified by the presence of dyslipidemia, abdominal obesity, and overweight/obesity.ConclusionWomen exposed to the Chinese famine during fetal, childhood, and adolescence were positively associated with hyperuricemia, while men exhibited a negative association during fetal and childhood. Additionally, the effect of famine on hyperuricemia in exposed women appears to be intensified by the presence of dyslipidemia, abdominal obesity, and overweight/obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure to Chinese famine and the risk of hyperuricemia in later life: a population-based cross-sectional study

Xiong,

Liu,

Tang

et al. 2024

Front. Nutr.

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“…This aligns with previous research suggesting that individuals in childhood and adolescence may be more vulnerable to famine-related stress than in infancy. Consequently, famine experiences in the stages of childhood and adolescence potentially elevates the likelihood of cataract development during the adult stage ( 16 ). One potential explanation could be that individuals enduring famine in extremely early stages of life have opportunities to overturn the effects of nutritional deprivation and attain subsequent catch-up growth.…”

Section: Discussionmentioning

confidence: 99%

“…The famine exposure period was specified as ranging from 1959 to 1961. According to previous research and life cycle theory, school age and teenage periods are critical stages of growth and development, susceptible to nutritional deficiencies ( 16 , 17 ). Adulthood follows the teenage period, marking completion of full physical development ( 18 ).…”

Section: Methodsmentioning

confidence: 99%

Famine exposure in early life increases risk of cataracts in elderly stage

Feng,

Niu,

Zhu

et al. 2024

Front. Nutr.

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BackgroundEpidemiological studies have shown that early-life nutritional deficiencies are associated with an increased risk of diseases later in life. This study aimed to explore the correlation between famine exposure during the early stages of life and cataracts.MethodsWe included 5,931 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) 2018 cross-sectional data in our study. Subjects were categorized into three groups by their age during the famine: adulthood group, school age famine exposure group, and teenage famine exposure group. Utilizing binary logistic regression models, we investigated the relationship between early-life famine exposure and cataracts.ResultsCompared to the adulthood group, both the school age exposure group (OR = 2.49, 95%CI = 1.89–3.27) and teenage exposure group (OR = 1.45, 95%CI = 1.20–1.76) had a heightened risk of developing cataracts in elderly stage. And the sex differences in the impact of famine during early years on elderly cataract risk were observed, particularly indicating a higher risk among women who experienced childhood famine compared to men with similar exposure.ConclusionFamine exposure during the early stages of life is associated with a heightened risk of developing cataracts in old age. To prevent cataracts in elderly individuals, particularly in females, measures should be taken to address nutritional deficiencies in these specific periods.

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“…As opposed to the Dutch famine, the Chinese famine, which took place from 1959 to 1962 and resulted in approximately 20 to 30 million deaths, [10] affected the Chinese mainland in the most severe and largest way. Recent studies suggest that exposure to the Chinese famine in early life increases the risk of developing cardiovascular diseases, [11] hyperuricemia, [12] and diabetes. [13] Nonetheless, evidence regarding the association between famine exposure and dyslipidemia is limited.…”

Section: Introductionmentioning

confidence: 99%

Female exposed to the Chinese famine increases the risk of dyslipidemia in later life

et al. 2023

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The Developmental Origins of Health and Disease theory suggests that early-life malnutrition is associated with an increased risk of chronic disease in adulthood. In this study, we aimed to analyze the association between exposure to the Chinese famine during fetal, childhood, and adolescence, while also exploring potential gender disparities in this association. From August 2018 to 2022 December, a 3-stage stratified random sampling method was employed to recruit 6916 eligible participants in Chongqing for this study. The participants were enrolled into 4 cohorts based on their birthdates: non-exposed, fetal-exposed, childhood-exposed, and adolescence-exposed. Participants were defined as having dyslipidemia according to the 2016 Chinese guideline for the management of dyslipidemia in adults, as well as self-reported dyslipidemia. In total, 6916 eligible participants were interviewed, including 1686 participants exposed when fetal, 1626 participants exposed during childhood, 1648 participants exposed during adolescence, and 1956 participants who had no exposure. The prevalence of dyslipidemia in the non-exposed, fetal-exposed, childhood-exposed, and adolescence-exposed cohorts was 21.43%, 25.00%, 24.38%, 22.52% in males and 20.00%, 36.57%, 34.60%, 32.59% in females, respectively. There was an increased risk of dyslipidemia among females exposed to the Chinese famine during the fetal (odds ratio [OR] = 1.613, 95% confidence interval [CI]: 1.179–2.205), childhood (OR = 1.857, 95% CI: 1.384–2.491), adolescence (OR = 1.531, 95% CI: 1.137–2.060) stage, However, no significant association was observed in male adults. Exposure to the Chinese famine during fetal, childhood, and adolescence stages increases the risk of dyslipidemia in adulthood in females, but not in males. The observed gender differences may be attributed to mortality advantage and son preference in China.

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Early-life exposure to the Chinese famine and risk of hyperuricaemia in adult females in Qingdao

Cited by 4 publications

References 44 publications

Exposure to Chinese famine and the risk of hyperuricemia in later life: a population-based cross-sectional study

Exposure to Chinese famine and the risk of hyperuricemia in later life: a population-based cross-sectional study

Famine exposure in early life increases risk of cataracts in elderly stage

Female exposed to the Chinese famine increases the risk of dyslipidemia in later life

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