Early life exposure to noise alters the representation of auditory localization cues in the auditory space map of the barn owl

Efrati, Adi; Gutfreund, Yoram

doi:10.1152/jn.00078.2011

Cited by 15 publications

(11 citation statements)

References 62 publications

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“…Consistent with recent studies in adult cats (Pienkowski and Eggermont, 2009, 2010a,c), these results demonstrate a similar degree of environmental influence on the brain representation of sensory information in adult rats as that reported in juveniles of rats (Moucha and Kilgard, 2006; Dahmen and King, 2007; Keuroghlian and Knudsen, 2007; Eggermont, 2008; Barnes and Finnerty, 2010) and other species (Marler et al, 1973; Iyengar and Bottjer, 2002; Aizawa and Eggermont, 2007; Speechley et al, 2007; Eggermont, 2008; Efrati and Gutfreund, 2011; for reviews see: Moucha and Kilgard, 2006; Dahmen and King, 2007; Keuroghlian and Knudsen, 2007; Barnes and Finnerty, 2010). Behaviorally, the noise-exposed adult rats showed impairments in detecting fine pitch variations embedded in a tone sequence.…”

Section: Introductionsupporting

confidence: 60%

“…In young rats and cats, continuous exposure to white noise prevents development of a tonotopic map and refinement of neural response selectivity in the primary auditory cortex (A1) (Zhang et al, 2001; Chang and Merzenich, 2003; Aizawa and Eggermont, 2007; Speechley et al, 2007). Rearing in a continuous-noise environment affects vocal learning in songbirds (Marler et al, 1973; Iyengar and Bottjer, 2002) and disrupts development of the auditory space map in barn owls (Efrati and Gutfreund, 2011). Early abnormal sound experience in rat (Han et al, 2007) and mice pups (Takahashi et al, 2006) modified the tonotopic map in A1 and impaired frequency discrimination in adult rats (Han et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Auditory map reorganization and pitch discrimination in adult rats chronically exposed to low-level ambient noise

Zheng¹

2012

Front. Syst. Neurosci.

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Behavioral adaption to a changing environment is critical for an animal's survival. How well the brain can modify its functional properties based on experience essentially defines the limits of behavioral adaptation. In adult animals the extent to which experience shapes brain function has not been fully explored. Moreover, the perceptual consequences of experience-induced changes in the brains of adults remain unknown. Here we show that the tonotopic map in the primary auditory cortex of adult rats living with low-level ambient noise underwent a dramatic reorganization. Behaviorally, chronic noise-exposure impaired fine, but not coarse pitch discrimination. When tested in a noisy environment, the noise-exposed rats performed as well as in a quiet environment whereas the control rats performed poorly. This suggests that noise-exposed animals had adapted to living in a noisy environment. Behavioral pattern analyses revealed that stress or distraction engendered by the noisy background could not account for the poor performance of the control rats in a noisy environment. A reorganized auditory map may therefore have served as the neural substrate for the consistent performance of the noise-exposed rats in a noisy environment.

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Section: Introductionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Auditory map reorganization and pitch discrimination in adult rats chronically exposed to low-level ambient noise

Zheng¹

2012

Front. Syst. Neurosci.

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“…This was the thinking behind an experiment in which animals were reared in an illuminated room with multiple speakers arranged around the home cage to provide omni-directional broadband masking noise. Within this ‘noise room’, the blanket of sound effectively masked all but the loudest transient auditory stimuli 131,132 . Some superior colliculus auditory receptive fields did not contract normally during development, but many others appeared to do so.…”

Section: The Necessity Of Cross-modal Experiencementioning

confidence: 99%

Development of multisensory integration from the perspective of the individual neuron

2014

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The ability to use cues from multiple senses in concert is a fundamental aspect of brain function. It maximizes the brain’s use of the information available to it at any given moment and enhances the physiological salience of external events. Because each sense conveys a unique perspective of the external world, synthesizing information across senses affords computational benefits that cannot otherwise be achieved. Multisensory integration not only has substantial survival value but can also create unique experiences that emerge when signals from different sensory channels are bound together. However, neurons in a newborn’s brain are not capable of multisensory integration, and studies in the midbrain have shown that the development of this process is not predetermined. Rather, its emergence and maturation critically depend on cross-modal experiences that alter the underlying neural circuit in such a way that optimizes multisensory integrative capabilities for the environment in which the animal will function.

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“…Manipulation of spatial cues was achieved by plugging one ear (Mogdans and Knudsen, 1992, 1993, 1994a,b), by implanting a passive filtering device in the ear canal (Gold and Knudsen, 1999, 2000; Miller and Knudsen, 2001, 2003) or by raising barn owls in broadband masking noise (Efrati and Gutfreund, 2011). After about two months of manipulation, the responses to ITD and ILD were recorded in different nuclei of the auditory pathway (ICC, ICX, OT, and NO) and compared to units recorded in control animals.…”

Section: Plasticity In the Barn Owl's Inferior Colliculusmentioning

confidence: 99%

“…After about two months of manipulation, the responses to ITD and ILD were recorded in different nuclei of the auditory pathway (ICC, ICX, OT, and NO) and compared to units recorded in control animals. All of the above manipulations induced large changes in the tuning to binaural cues in higher order nuclei [OT (Mogdans and Knudsen, 1992; Gold and Knudsen, 1999; Efrati and Gutfreund, 2011), ICX (Gold and Knudsen, 2000, 2001), NO (Miller and Knudsen, 2003)]. Noise rearing resulted in broader ILD and ITD tuning curves and atypical asymmetrical ILD tuning curves in the OT.…”

Section: Plasticity In the Barn Owl's Inferior Colliculusmentioning

confidence: 99%

The representation of sound localization cues in the barn owl's inferior colliculus

Singheiser¹,

Gutfreund²,

Wagner³

2012

Front. Neural Circuits

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The barn owl is a well-known model system for studying auditory processing and sound localization. This article reviews the morphological and functional organization, as well as the role of the underlying microcircuits, of the barn owl's inferior colliculus (IC). We focus on the processing of frequency and interaural time (ITD) and level differences (ILD). We first summarize the morphology of the sub-nuclei belonging to the IC and their differentiation by antero- and retrograde labeling and by staining with various antibodies. We then focus on the response properties of neurons in the three major sub-nuclei of IC [core of the central nucleus of the IC (ICCc), lateral shell of the central nucleus of the IC (ICCls), and the external nucleus of the IC (ICX)]. ICCc projects to ICCls, which in turn sends its information to ICX. The responses of neurons in ICCc are sensitive to changes in ITD but not to changes in ILD. The distribution of ITD sensitivity with frequency in ICCc can only partly be explained by optimal coding. We continue with the tuning properties of ICCls neurons, the first station in the midbrain where the ITD and ILD pathways merge after they have split at the level of the cochlear nucleus. The ICCc and ICCls share similar ITD and frequency tuning. By contrast, ICCls shows sigmoidal ILD tuning which is absent in ICCc. Both ICCc and ICCls project to the forebrain, and ICCls also projects to ICX, where space-specific neurons are found. Space-specific neurons exhibit side peak suppression in ITD tuning, bell-shaped ILD tuning, and are broadly tuned to frequency. These neurons respond only to restricted positions of auditory space and form a map of two-dimensional auditory space. Finally, we briefly review major IC features, including multiplication-like computations, correlates of echo suppression, plasticity, and adaptation.

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Early life exposure to noise alters the representation of auditory localization cues in the auditory space map of the barn owl

Cited by 15 publications

References 62 publications

Auditory map reorganization and pitch discrimination in adult rats chronically exposed to low-level ambient noise

Auditory map reorganization and pitch discrimination in adult rats chronically exposed to low-level ambient noise

Development of multisensory integration from the perspective of the individual neuron

The representation of sound localization cues in the barn owl's inferior colliculus

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