Early-life exposure to endocrine disrupting chemicals associates with childhood obesity

Yang, Chunxue; Lee, Hin Kiu; Kong, Alice Pik Shan; Lim, Lee‐Ling; Cai, Zongwei

doi:10.6065/apem.2018.23.4.182

Cited by 26 publications

(23 citation statements)

References 132 publications

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“…5 Apart from genetic predisposition, lifestyle and environmental factors, such as exposure to endocrinedisrupting pollutants, can induce oxidative stress and strain the pancreatic β cells, increasing the risk of YOD. 6,7 In a territory-wide diabetes surveillance database of more than 0.4 million adults with diabetes in Hong Kong, 17% had YOD and spent, on average, 100 nights in hospital before the age of 75 years as a result of cardiovascular-renal diseases, mental illness, and sepsis. 8 As many as 20% to 50% of people with type 2 diabetes may experience anxiety, stress, and/or depression, especially women and people with YOD, which may negatively impact adherence with increased risk of poor glycaemic control and hypoglycaemia.…”

Section: Introductionmentioning

confidence: 99%

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Kong

Lew²,

Lau

et al. 2020

Diabetes Obesity Metabolism

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Aims To explore the pattern of insulin use and glycaemic control in Asian people with type 2 diabetes, stratified by gender, young‐onset diabetes (YOD; diagnosed before age 40 years), and diabetic kidney disease (DKD; estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73m2). Materials and methods We conducted a cross‐sectional analysis of 97 852 patients from 11 Asian countries/regions (2007–2017) included in the prospective Joint Asia Diabetes Evaluation (JADE) Register. Results Among 18 998 insulin users (47% women, mean ± SD age 59.2 ± 11.7 years, diabetes duration 13.2 ± 8.3 years, glycated haemoglobin [HbA1c] 72 ± 21.4 mmol/mol [8.74 ± 1.95%], median total daily insulin dose [TDD] 0.27–0.82 units/kg), 25% and 29.5% had YOD and DKD, respectively. Premixed (44%) and basal‐only (42%) insulin were the most common regimens. Despite being more commonly treated with these two regimens with higher insulin dosages, patients with YOD had worse HbA1c levels than their late‐onset peers (73 ± 20.5 vs. 71 ± 21.2 mmol/mol [8.82 ± 1.87% vs. 8.66 ± 1.94%]; P < 0.001). Fewer women than men attained an HbA1c level < 53 mmol/mol (7%; 15.7% vs 17.1%; P = 0.018). Adjusting for age, diabetes duration, TDD, HbA1c, eGFR, and use of oral glucose‐lowering drugs at baseline, the odds of self‐reported hypoglycaemia were higher in women (vs. men: adjusted odds ratio [aOR] 1.16, 95% confidence interval [CI] 1.05–1.28) and in patients with DKD treated with a premixed regimen (1.81 [95% CI 1.54–2.13] vs. 1.34 [95% CI 1.16–1.54] in non‐DKD; Pinteraction < 0.001). Compared to basal‐only regimens, premixed and basal‐bolus regimens had similar HbA1c reductions but were independently associated with increased odds of hypoglycaemia (1.65 [95% CI 1.45–1.88] and 1.88 [95% CI 1.58–2.23], respectively). Conclusions In this Asian population, there were varying patterns of insulin regimens with suboptimal glycaemic control, despite relatively high TDDs, which were influenced by gender, DKD, and YOD status.

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Section: Introductionmentioning

confidence: 99%

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Kong

Lew²,

Lau

et al. 2020

Diabetes Obesity Metabolism

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“…Effects on early development are of special concern as these effects are often irreversible. Oxidative stress caused by EDCs can be the mediator of several adverse health outcomes (e.g., obesity, diabetes, and cardiovascular disease in adulthood) [16,19,46]. With EDCs, there is also a possibility of damage to future generations (transgenerational inheritance) [10,16,17,27,28].…”

Section: Timing Of Exposure To Edcsmentioning

confidence: 99%

Human Health Consequences of Endocrine-Disrupting Chemicals

Heshmati¹

2021

Environmental Issues and Sustainable Development

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Daily use of chemicals is an essential part of modern life. Endocrine-disrupting chemicals (EDCs) are a heterogeneous group of exogenous chemicals or chemical mixtures that interfere with the action of hormones and consequently cause adverse effects to humans and wildlife. The number of EDCs has markedly increased over the past 60 years. Humans are constantly exposed to hundreds of EDCs mainly through air, water, and food. Exposure to EDCs (in utero or lifetime) may be a significant component of the environmental origin of several medical conditions. The developing fetus and neonate are more sensitive than adults to perturbation by EDCs. The prenatal damage can cause adverse consequences later in life (developmental origins of adult disease). In many cases, the damage is irreversible. There is also a possibility of transgenerational effects. By interfering with hormonal functions, EDCs can contribute to a variety of dysfunctions and diseases including obesity, diabetes, reproductive disorders, and cancers. Information on long-term effects of chronic, low-dose exposure to EDCs is relatively limited. EDCs represent a global threat for human health and cause a high cost for the society. Promoting public knowledge and initiating preventive measures will help minimizing the health and economic consequences of EDCs for future generations.

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“…ED-i su uglavnom lipofilni, mogu se akumulirati u masnom tkivu i djelovati kao bazen toksičnosti (npr. diklorodifeniltrikloroetan-DDT, poliklorinirani bifenili, polbromirani difenol eteri) (14).…”

Section: Mehanizam Djelovanja Endogenih Disruptoraunclassified

Possible consequences of early exposure to endocrine disruptors

Dodig¹,

Dodig²,

Pavić³

2019

Paediatr Croat

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Endokrini disruptori (ED) egzogene su kemikalije koje mijenjaju funkciju endokrinog sustava, čime dovode do štetnih učinaka na zdravlje životinja i ljudi. U skupinu trajno prisutnih štetnih spojeva ubrajaju se sintetizirani pesticidi, industrijske kemikalije i njihovi nusproizvodi, prirodni mikotoksini i fitoestrogeni. Drugu skupinu ED-a čine proizvodi s kojima se u kontakt dolazi povremeno (proizvodi široke potrošnje, farmaceutski agensi). Štetno djelovanje ED-a ispituje se na životinjama koje obitavaju u prirodi, na laboratorijskim životinjama, staničnim kulturama te u humanim epidemiološkim i kliničkim istraživanjima. Posljedice rane izloženosti ED-u dokazane su u poremećajima reproduktivnog i endokrinog sustava, pojavi metaboličkih poremećaja i bolesti, neurološkim poremećajima. Neke od posljedica prenose se na sljedeće generacije. U ranoj dječjoj dobi važno je otkriti i istražiti indikatore fetalne izloženosti, identificirati skupine velikog i malog rizika izloženosti ED-u, kako bi se mogla provesti prospektivna istraživanja korelacije izloženosti s kliničkim posljedicama tijekom novorođenačkog i dojenačkog razdoblja, djetinjstva i adolescencije.Ključne riječi: ENDOKRINI DISRUPTORI; PRENATALNA IZLOŽENOST; ENDOKRINI SUSTAV; PUBERTET 1 Umirovljena naslovna izvanredna profesorica, Zavod za medicinsku biokemiju i hematologiju, Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu 2 Hrvatski zavod za javno zdravstvo, Služba za toksikologiju, Odjel za biocide, Zagreb 3 Klinika za pedijatriju, Klinika za dječje bolesti, Zagreb Adresa za dopisivanje: Slavica Dodig, specijalistica medicinske biokemije,

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Early-life exposure to endocrine disrupting chemicals associates with childhood obesity

Cited by 26 publications

References 132 publications

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Real‐world data reveal unmet clinical needs in insulin treatment in Asian people with type 2 diabetes: the Joint Asia Diabetes Evaluation (JADE) Register

Human Health Consequences of Endocrine-Disrupting Chemicals

Possible consequences of early exposure to endocrine disruptors

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