Early life exposure to di(2-ethylhexyl)phthalate causes age-related declines associated with insulin/IGF-1-like signaling pathway and SKN-1 in Caenorhabditis elegans

How, Chun Ming; Yen, Pei-Ling; Wei, Chia-Cheng; Li, Shangwei; Liao, Vivian Hsiu‐Chuan

doi:10.1016/j.envpol.2019.04.141

Cited by 27 publications

(13 citation statements)

References 52 publications

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“…Heat‐shock proteins (HSPs) are molecular chaperones that play an important role under heat stress 10 . Under stress conditions, hsf‐1 could activate the transcription of genes that encode for various chaperones (such as hsp‐12.6 , hsp‐16.2 , and hsp‐16.49 ) 11 . It is not realistic to introduce mutations to prolong life, but if natural nutrients can be found to inhibit IIS pathway or increase the FOXO signaling, life extension may be achieved.…”

Section: Introductionmentioning

confidence: 99%

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

et al. 2021

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Tangeretin is a polymethoxylated flavonoid naturally occurred in citrus fruits with many pharmacological activities, such as anti‐inflammatory, antiproliferative, and neuroprotective properties. A previous study reported that tangeretin‐enriched orange extract could prolong the lifespan in Caenorhabditis elegans. However, the antiaging effect of tangeretin remains uncertain. In this study, we used the model organism C. elegans to conduct a lifespan test, observed the aging‐related functional changes of nematodes, the fluorescence changes of stress‐related proteins (DAF‐16 and HSP‐16.2) and its response to stress assay, and monitored the effect of tangeretin on the mRNA expression levels. The results showed that tangeretin supplementation (30 and 100 μM) extended the mean lifespan, slowed aging‐related functional declines, and increased the resistance against heat‐shock stress. Furthermore, tangeretin upregulated the mRNA expression of daf‐16, hsp‐16.2, and hsp‐16.49, promoted the nuclear localization of DAF‐16, and enhanced the fluorescence intensity of HSP‐16.2, while it had no effect on the lifespan of daf‐2, age‐1, and daf‐16 mutants. The current findings suggest that tangeretin can significantly extend the lifespan and enhance heat stress tolerance in an insulin/insulin‐like growth factor signaling dependent manner.

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Section: Introductionmentioning

confidence: 99%

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

et al. 2021

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“…diversicolor , DBP affects oxidative stress, lipid and energy metabolism, and osmoregulation 17 . In other invertebrates, including Chironomus riparius 42 , Drosophila melanogaster 43 , and Caenorhabditis elegans 15 , phthalates alter endocrine pathways. The changes affect the ecdysone response as well as the expression of insulin-like peptide.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the impact of three phthalates on the freshwater gastropod Physella acuta at the transcriptional level

Prieto-Amador

Caballero

Martínez-Guitarte

2021

Sci Rep

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Plastic pollution is one of the leading environmental problems. Phthalates are widely used plastic additives released into the environment. Although the effects of phthalates on vertebrates have been extensively studied, there is a knowledge gap regarding their effects on invertebrates. This work analyzes the impact of three phthalates, diethyl phthalate (DEP), benzyl butyl phthalate (BBP), and bis-(2-ethylhexyl) phthalate (DEHP), on the gastropod Physella acuta at the molecular level to establish the putative pathways involved in its response to them. By real-time PCR, we obtained the expression profile of 30 genes in animals exposed for 1 week to 0.1, 10, and 1000 μg/L of each phthalate. The genes cover DNA repair, detoxification, apoptosis, oxidative and stress responses, immunity, energy reserves, and lipid transport. The results show that while DEP and DEHP did not alter the mRNA levels, BBP modulated almost all the analyzed genes. It can be concluded that the impact of BBP is extensive at the molecular level. However, it cannot be dismissed that the increase in transcriptional activity is a general response due to this compound’s well-known role as an endocrine disruptor. Additional research is needed to elucidate the differences observed in the impact of these compounds on the gastropod P. acuta.

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“…The decrease of IGF-1 level is related to the improvement of HSCs self-renewal [124,125]. At the same time, studies have found that insulin, IGF-1, and growth hormone can increase the number of NSCs and GSCs in aging animals [126][127][128], suggesting that NSCs or GSCs may increase their numbers through the above cyclic factors at the expense of long-term self-renewal or affect the steady-state process. TGF-β is also a cyclic factor that regulates stem cell function during aging.…”

Section: Niche Deteriorationmentioning

confidence: 98%

The Mechanism of Stem Cell Aging

et al. 2022

Stem Cell Rev and Rep

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Stem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for maintaining the tissue homeostasis. The depletion of stem cells is closely related to the occurrence of body aging and aging-related diseases. Therefore, revealing the molecular mechanisms of stem cell aging will set new directions for the therapeutic application of stem cells, the study of aging mechanisms, and the prevention and treatment of aging-related diseases. This review comprehensively describes the molecular mechanisms related to stem cell aging and provides the basis for further investigations aimed at developing new anti-stem cell aging strategies and promoting the clinical application of stem cells.

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Early life exposure to di(2-ethylhexyl)phthalate causes age-related declines associated with insulin/IGF-1-like signaling pathway and SKN-1 in Caenorhabditis elegans

Cited by 27 publications

References 52 publications

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

Tangeretin promotes lifespan associated with insulin/insulin‐like growth factor‐1 signaling pathway and heat resistance in Caenorhabditis elegans

Analysis of the impact of three phthalates on the freshwater gastropod Physella acuta at the transcriptional level

The Mechanism of Stem Cell Aging

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