Early-life exposure to caffeine affects the construction and activity of cortical networks in mice

Fazeli, Walid; Zappettini, Stefania; Marguet, Stephan L.; Grendel, Jasper; Esclapez, Monique; Bernard, Christophe; Isbrandt, Dirk

doi:10.1016/j.expneurol.2017.05.013

Cited by 33 publications

(31 citation statements)

References 85 publications

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“…We recorded local field potentials (LFPs) along the CA1-dentate gyrus axis using linear 32-site silicon probes in awake head-fixed neonates. We observed similar activity patterns in P4 hippocampus of both WT and NKCC1 KO Emx1 mice: sharp waves (SPWs) with a phase reversal in the CA1 pyramidal layer and short-lasting oscillations in the 10-30 Hz (beta) frequency range (hippocampal network oscillations, HNOs; Figures 5A and 5B) as previously described (Fazeli et al, 2017;Marguet et al, 2015). Depth profiles of SPWs were comparable to those described in rat pups (Valeeva et al, 2019) ('rad/lm SPW' in Figure 5C).…”

Section: Hippocampal Sharp Waves In Vivo Persist In the Conditional Asupporting

confidence: 80%

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network developmentin vivo

Graf

Zhang

Marguet

et al. 2020

Preprint

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NKCC1 is the primary transporter mediating chloride uptake in immature principal neurons, but its role in the development of in vivo network dynamics and cognitive abilities remains unknown. Here, we address the function of NKCC1 in developing mice using electrophysiological, optical and behavioral approaches. We report that NKCC1 deletion from telencephalic glutamatergic neurons decreases in-vitro excitatory GABA actions and impairs neuronal synchrony in neonatal hippocampal brain slices. In vivo, it has a minor impact on correlated spontaneous activity in the hippocampus and does not affect network activity in the intact visual cortex. Moreover, long-term effects of the developmental NKCC1 deletion on synaptic maturation, network dynamics and behavioral performance are subtle. Our data reveal a neural network function of depolarizing GABA in the hippocampus in vivo, but challenge the hypothesis that NKCC1 is essential for major aspects of hippocampal development.

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Section: Hippocampal Sharp Waves In Vivo Persist In the Conditional Asupporting

confidence: 80%

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network developmentin vivo

Graf

Zhang

Marguet

et al. 2020

Preprint

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“…The offspring of rat dams that received caffeine during pregnancy in doses that would be equivalent to about three to four cups of coffee a day in humans were shown to be more susceptible to seizures induced by hyperthermia or flurothyl than controls that received only water [40,41]. In the pups that had been exposed to caffeine, there was a delayed migration of GABAergic neurons into the hippocampus which was not found in controls.…”

Section: Seizures After Maternal Caffeine Exposurementioning

confidence: 94%

The Use of Caffeine by People with Epilepsy: the Myths and the Evidence

Bauer

Sander

2019

Curr Neurol Neurosci Rep

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Purpose of review: Caffeine is the most widely consumed central nervous stimulant. For people with epilepsy, it is often unclear whether drinking coffee carries a risk of triggering seizures. Recent findings: The relationship between caffeine, seizures, epilepsy and anti-seizure drugs is not fully understood. Clinical studies are scarce. In animal models, caffeine can increase seizure susceptibility but can also protect from seizures. Effects seem dose-dependent and, influenced but the duration of intake and the developmental stage at which caffeine exposure started. Caffeine lowers the efficacy of several anti-seizure medication, especially topiramate. Summary: It is unclear how these findings, mainly from animal studies can be translated to the clinical condition. At present, there is no evidence to advice people with epilepsy against the use or overuse of caffeine. Until clinical studies suggest otherwise, caffeine intake should be considered as a factor in achieving and maintaining seizure control in epilepsy.

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“…In Vivo Electrophysiology. Adult mice were recorded under urethane anesthesia using linear 16-site silicon probes inserted into the dorsal hippocampus, as previously described (70,71). SWS-and REM-like epochs were identified from the multitaper spectrograms calculated from the LFP.…”

Section: Methodsmentioning

confidence: 99%

Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks

Gao

Castro-Gomez

Grendel

et al. 2018

Proc. Natl. Acad. Sci. U.S.A.

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During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.

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Early-life exposure to caffeine affects the construction and activity of cortical networks in mice

Cited by 33 publications

References 85 publications

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network developmentin vivo

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network developmentin vivo

The Use of Caffeine by People with Epilepsy: the Myths and the Evidence

Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks

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