Early Life Events: Infants with Pyloric Stenosis Have a Higher Risk of Developing Chronic Abdominal Pain in Childhood

Saps, Miquel; Bonilla, Silvana

doi:10.1016/j.jpeds.2011.03.018

Cited by 56 publications

(35 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…proposed that various mechanisms such as genetics, early life events, environmental, gastrointestinal and psychosocial factors act together in a complex interplay ultimately resulting in an alteration to the gut-brain axis 10,11,12,13,14,15,16 . Afferent signals from the gastrointestinal tract transmitted via the pain pathways are subsequently amplified and the patient's perception of painful stimuli is in turn enhanced 17 .…”

Section: Pathophysiologymentioning

confidence: 99%

Gastrointestinal and nutritional problems in neurologically impaired children

Quitadamo

Thapar

Staiano

et al. 2016

European Journal of Paediatric Neurology

View full text Add to dashboard Cite

Fax: + 44 20 7813 8382Gut Motility disorders comprise a heterogeneous group of disorders that result from disruption of the functional integrity of the intrinsic neuromusculature of the gastrointestinal (GI) tract. This intrinsic neuromusculature includes the smooth muscle layers, the intrinsic nervous system of the GI tract (enteric nervous system or ENS) and the interstitial cells of Cajal. The contribution of each of these components to function can be compromised by alterations in structure (ranging from absence to derangement in numbers and/or anatomy) or of function (complete or partial failure in physiological function). This pathology can be primary or secondary to a number of insults e.g. infections, inflammation, toxins etc. In children disorders may be congenital being present from birth or acquired later in life. Finally involvement of the enteric neuromusculature can be patchy/segmental or affect the gastrointestinal tract diffusely.Neuro-gastroenterology is the study of the interface of all aspects of the gastrointestinal tract or digestive system with the different branches of the body's nervous system including the enteric, central and autonomic nervous systems. The combined terms 'Neurogastroenterology and motility' are designed to encompass the study of all the components of the enteric neuromuscualture and their modulating influences and represents one of the fastest growing areas in gastroenterology clinical practice and research. This chapter aims to address some of the most common neurogastroenterology and motility conditions seen in clinical practice ranging from those with defined pathology to those which fall under the umbrella of functional gastrointestinal disorders. The latter comprise some of the commonest but challenging disorders and the term 'functional' reflects the fact that in the majority of such conditions no organic cause can be found. It should also be noted that at the present time many functional disorders e.g. abdominal pain-related functional GI disorders, represent symptom complexes that can further be subdivided into more discrete entities e.g. irritable bowel syndrome, functional abdominal pain etc depending on the nature, location and associations of the symptoms. Clinicians will often rely on the presence or absence of 'red flags' e.g. associated weight loss, severe or significant symptoms etc to decide whether patients are likely to have organic or functional disorders. Exhaustive investigations in the latter are likely to prove fruitless, expensive and perpetuate 'illness behaviours' in the patients. Abdominal pain-related functional gastrointestinal disorders IntroductionAbdominal pain-related functional gastrointestinal disorders (FGID) constitute a spectrum of conditions characterised by the presence of recurrent abdominal pain in the absence of any defined pathology 1 . In the past these disorders fell under the single term 'Recurrent abdominal pain' (RAP) but have since been recategorised under an international initiative (Rome Foundation) to improve the dia...

show abstract

Section: Pathophysiologymentioning

confidence: 99%

Gastrointestinal and nutritional problems in neurologically impaired children

Quitadamo

Thapar

Staiano

et al. 2016

European Journal of Paediatric Neurology

View full text Add to dashboard Cite

show abstract

“…The latter has been closely related not only to central2 but also to peripheral sensitization 3,4. In humans, studies have attempted to confirm these findings, suggesting the putative key role of birth weight < 1.5 kg, repetitive gastric suctions in neonates, and surgical correction of pyloric stenosis 5-7…”

Section: Introductionmentioning

confidence: 98%

Functional Gastrointestinal Disorders Induced by Esophageal Atresia Surgery: Is It Valid in Humans?

Halac

Revillion²,

Michaud³

et al. 2012

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsFunctional gastrointestinal disorders (FGID) affect 15%-20% of the general pediatric and adult population. Animal models suggest that a neonatal stress such as invasive procedures and maternal separation could be responsible for visceral hypersensitivity and FGID. We tested the hypothesis that congenital esophageal atresia (EA), a condition corrected during the neonatal period and associated with multiple stresses, is a clinically significant risk factor for the development of FGID later in life. We postulated that, to be clinically significant, the effect of neonatal stress on the incidence of FGID should be as strong as that of enteric infections in the development of irritable bowel syndrome in children.MethodsSubjects with EA and healthy controls were enrolled in this multicenter cohort study. Gastrointestinal symptoms were assessed by a questionnaire and FGID was diagnosed using the Rome III criteria.ResultsFifty-three children (25 girls; median age, 12 years) with EA were compared to 72 age- and sex-matched controls. Although 11 children with EA (21%) had a FGID diagnosis versus 8 controls (11%), this difference was not significant (χ2 = 2.20, P > 0.05). In subjects with EA, the presence of associated malformations, the occurrence of complications during the first month, and the length of hospital stay > 30 days did not influence the incidence of FGID. Chronic abdominal pain was present in 38% of subjects with EA versus 25% of controls (P > 0.05).ConclusionsNeonatal stress secondary to surgical correction of EA is not a clinically significant risk factor for the development of FGID in childhood.

show abstract

“…Тем не менее, значение молочной аллергии в старшем возрасте иногда недооце-нивается. Так, аллергия к БКМ может неочевидно пер-систировать в школьном возрасте и ассоциироваться с такими проявлениями аллергии, как риноконъюнкти-вит, атопический дерматит или бронхиальная астма [63], а также являться причиной повторяющихся эпизодов абдоминальной боли [64]. Соответственно, истинная частота формирования толерантности у детей с аллер-гией к БКМ может быть еще ниже, чем представляется в настоящее время [59,65].…”

Section: заключениеunclassified