Early life environmental predictors of asthma age‐of‐onset

Ferry, Olivia R; Duffy, David L.; Ferreira, Manuel

doi:10.1002/iid3.27

Cited by 11 publications

(11 citation statements)

References 62 publications

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“…An association between carpets and early onset asthma was also observed in the study by Ferry and coworkers [ 30 ] where they looked to identify environmental exposures associated with early onset of asthma and potential hereditary impact. More than 1000 individuals with physician diagnosed asthma and disease onset by two years or older were studied.…”

Section: Resultssupporting

confidence: 52%

“…The majority of studies appear to find correlation between carpet floors and adverse health outcomes such as respiratory infections, asthma worsening and age at asthma onset [ 27 , 29 , 30 , 31 , 34 ]. Carpets in the children’s bedroom have also been associated with increased risk of asthma [ 31 , 33 ] However, the current knowledge is insufficient to quantify the risk for these outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Do Carpets Impair Indoor Air Quality and Cause Adverse Health Outcomes: A Review

Becher

Øvrevik

Schwarze

et al. 2018

IJERPH

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Several earlier studies have shown the presence of more dust and allergens in carpets compared with non-carpeted floors. At the same time, adverse effects of carpeted floors on perceived indoor air quality as well as worsening of symptoms in individuals with asthma and allergies were reported. Avoiding extensive carpet use in offices, schools, kindergartens and bedrooms has therefore been recommended by several health authorities. More recently, carpet producers have argued that former assessments were obsolete and that modern rugs are unproblematic, even for those with asthma and allergies. To investigate whether the recommendation to be cautious with the use of carpets is still valid, or whether there are new data supporting that carpet flooring do not present a problem for indoor air quality and health, we have reviewed the literature on this matter. We have not found updated peer reviewed evidence that carpeted floor is unproblematic for the indoor environment. On the contrary, also more recent data support that carpets may act as a repository for pollutants which may become resuspended upon activity in the carpeted area. Also, the use of carpets is still linked to perception of reduced indoor air quality as well as adverse health effects as previously reported. To our knowledge, there are no publications that report on deposition of pollutants and adverse health outcomes associated with modern rugs. However, due to the three-dimensional structure of carpets, any carpet will to some extent act like a sink. Thus, continued caution should still be exercised when considering the use of wall-to-wall carpeted floors in schools, kindergartens and offices, as well as in children’s bedrooms unless special needs indicate that carpets are preferable.

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Section: Resultssupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Do Carpets Impair Indoor Air Quality and Cause Adverse Health Outcomes: A Review

Becher

Øvrevik

Schwarze

et al. 2018

IJERPH

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“…In childhood, candidate environmental-risk factors that might affect age of onset include the timing, frequency, and duration of chest infections, allergen exposure, pet ownership, maternal smoking, and low-quality diet during pregnancy. [47][48][49][50][51][52][53] In adulthood, additional risk factors might include occupational exposures, active smoking, and obesity. 20,22,[54][55][56] To identify genetic risk factors that could be specific to COA or AOA, we performed two GWASs in the UK Biobank study.…”

Section: Discussionmentioning

confidence: 99%

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Ferreira

Mathur

Vonk

et al. 2019

The American Journal of Human Genetics

220

240

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The extent to which genetic risk factors are shared between childhood-onset (COA) and adult-onset (AOA) asthma has not been estimated. On the basis of data from the UK Biobank study (n ¼ 447,628), we found that the variance in disease liability explained by common variants is higher for COA (onset at ages between 0 and 19 years; h 2 g ¼ 25.6%) than for AOA (onset at ages between 20 and 60 years; h 2 g ¼ 10.6%). The genetic correlation (r g ) between COA and AOA was 0.67. Variation in age of onset among COA-affected individuals had a low heritability (h 2 g ¼ 5%), which we confirmed in independent studies and also among AOA-affected individuals. To identify subtype-specific genetic associations, we performed a genome-wide association study (GWAS) in the UK Biobank for COA (13,962 affected individuals) and a separate GWAS for AOA (26,582 affected individuals) by using a common set of 300,671 controls for both studies. We identified 123 independent associations for COA and 56 for AOA (37 overlapped); of these, 98 and 34, respectively, were reproducible in an independent study (n ¼ 262,767). Collectively, 28 associations were not previously reported. For 96 COA-associated variants, including five variants that represent COA-specific risk factors, the risk allele was more common in COA-than in AOA-affected individuals. Conversely, we identified three variants that are stronger risk factors for AOA. Variants associated with obesity and smoking had a stronger contribution to the risk of AOA than to the risk of COA. Lastly, we identified 109 likely target genes of the associated variants, primarily on the basis of correlated expression quantitative trait loci (up to n ¼ 31,684). GWAS informed by age of onset can identify subtype-specific risk variants, which can help us understand differences in pathophysiology between COA and AOA and so can be informative for drug development.

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“…Early‐onset asthma was defined as asthma symptoms beginning before the patient's second birthday, as previously described 26 …”

Section: Methodsmentioning

confidence: 99%

Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4‐Year follow‐up

Sousa

Cabral

Martins

et al. 2020

Pediatric Pulmonology

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Background Asthma is a disease with reversible bronchoconstriction; however, some patients develop fixed airflow obstruction (FAO). Previous studies have reported the incidence and risk factors of FAO in adults; however, the corresponding factors in children remain poorly understood. Aim To evaluate the incidence and risk factors of FAO in children and adolescents with asthma. Method Observational and prospective cohort study with a 4‐year follow‐up of clinically stable patients with asthma (from 6‐8 years old). Anthropometric data, history of asthma, number of hospitalizations, frequent exacerbations, asthma severity, asthma control, inhaled corticosteroid dose, atopy, and lung function were analyzed as potential risk factors for FAO. FAO was defined by a ratio of the forced expiratory volume in the first second to the forced vital capacity below the lower limit of normal, even after inhaled and oral corticosteroid treatment. Results Four hundred and twenty‐eight patients were recruited, and 358 were analyzed. The FAO incidence in children and adolescents with asthma was 9.5% (n = 34), starting at 10 years of age. Age, body mass index, hospitalizations for asthma, bronchodilator response, frequent exacerbations, length of exacerbations, and asthma severity were associated with FAO. Frequent exacerbations (odds ratio [OR] = 4.0; 95% confidence interval [CI] = 1.3‐11.7) and asthma severity categorized as steps 4 to 5 (OR = 3.5; 95% CI = 1.6‐7.6) remained risk factors. Conclusions Frequent exacerbations and asthma severity are the risk factors for FAO in children and adolescents with asthma.

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Early life environmental predictors of asthma age‐of‐onset

Cited by 11 publications

References 62 publications

Do Carpets Impair Indoor Air Quality and Cause Adverse Health Outcomes: A Review

Do Carpets Impair Indoor Air Quality and Cause Adverse Health Outcomes: A Review

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4‐Year follow‐up

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