Early-Life Environmental Exposures and Blood Pressure in Children

Warembourg, Charline; Maitre, Léa; Tamayo-Uria, Ibon; Fossati, Serena; Roumeliotaki, Theano; Aasvang, Gunn Marit; Andrušaitytė, Sandra; Casas, Maribel; Cequier, Enrique; Chatzi, Leda; Dėdelė, Audrius; González, J. Blanco; Haug, Line Småstuen; Hernández-Ferrer, Carles; Heude, Barbara; Karachaliou, Marianna; Krog, Norun Hjertager; McEachan, Rosemary; Nieuwenhuijsen, Mark; Petravičienė, Inga; Quentin, Joane; Robinson, Oliver; Sakhi, Amrit Kaur; Slama, Rémy; Thomsen, Cathrine; Urquiza, José; Vafeiadi, Marina; West, Jane; Wright, John; Vrijheid, Martine; Basagaña, Xavier

doi:10.1016/j.jacc.2019.06.069

Cited by 115 publications

(99 citation statements)

References 41 publications

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“…Recently, several groups assessed the effect of phthalate exposure on glycemia, hypertensive, and vitamin D homeostasis during pregnancy and hypothesized that the effect may associate with pregnancy complications, including GDM and pregnancy-induced hypertensive diseases (42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54). So it is important to characterize the potential risk of phthalate exposure during pregnancy.…”

Section: Prenatal Phthalate Exposure and Complication Of Pregnancymentioning

confidence: 99%

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. This article aims to review the endocrine impairment and potential outcomes of prenatal phthalate exposure. Prenatal exposure phthalates would disrupt the levels of thyroid, sex hormone, and 25-hydroxyvitamin D in pregnant women or offspring, which results in preterm birth, preeclampsia, maternal glucose disorders, infant cryptorchidism, infant hypospadias, and shorter anogenital distance in newborns, as well as growth restriction not only in infants but also in early adolescence and childhood. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

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Section: Prenatal Phthalate Exposure and Complication Of Pregnancymentioning

confidence: 99%

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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“…The results obtained are from 1277 children (age 6–11 years) from the European HELIX (Human Early-Life Exposome) project that gathered data from six cohorts from different countries (United Kingdom, France, Spain, Lithuania, Norway, and Greece). A wide range of exposures was evaluated in the HELIX project, pregnancy blood and urine samples were stored, and the systolic and diastolic BP were measured from the children [ 76 ]. Besides its large number of participants, the sample size was very small, taking into account the various exposures investigated.…”

Section: Human Studiesmentioning

confidence: 99%

Phthalates Implications in the Cardiovascular System

Mariana

Cairrão

2020

JCDD

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Today’s sedentary lifestyle and eating habits have been implicated as some of the causes of the increased incidence of several diseases, including cancer and cardiovascular diseases. However, environmental pollutants have also been identified as another possible cause for this increase in recent decades. The constant human exposure to plastics has been raising attention regarding human health, particularly when it comes to phthalates. These are plasticizers used in the manufacture of industrial and consumer products, such as PVC (Polyvinyl Chloride) plastics and personal care products, with endocrine-disrupting properties, as they can bind molecular targets in the body and interfere with hormonal function. Since these compounds are not covalently bound to the plastic, they are easily released into the environment during their manufacture, use, or disposal, leading to increased human exposure and enhancing health risks. In fact, some studies have related phthalate exposure with cardiovascular health, having already shown a positive association with the development of hypertension and atherosclerosis in adults and some cardiometabolic risk factors in children and adolescents. Therefore, the main purpose of this review is to present and relate the most recent studies concerning the implications of phthalates effects on the cardiovascular system.

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“…High blood pressure (BP) in childhood predicts increased risk of hypertension and cardiovascular events in later life ( Lurbe and Ingelfinger, 2016 ; Oikonen et al., 2016 ). Few studies have examined maternal prenatal BPA exposure and child cardio-metabolic risk factors, and the three existing studies have reported inconsistent findings ( Bae et al., 2017 ; Vafeiadi et al., 2016 ; Warembourg et al., 2019 ). A prospective study conducted in South Korea reported a positive association of prenatal urinary BPA concentration with DBP in boys, and SBP in girls at age 4 years with BPA above certain threshold, and a negative prenatal-BPA and SBP association in girls with BPA below the threshold ( Bae et al., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…A similar prospective study in Greece reported that prenatal urinary BPA was associated with lower BMI and adiposity measures in girls (assessed at 2.5 and 4 years of age) and increase of such factors in boys, but no associations with child cardiometabolic risk factors (BP, total cholesterol or high-density lipoprotein (HDL) cholesterol) were observed in children aged 4 years ( Vafeiadi et al., 2016 ). In a recent analysis of data from the European Human Early-Life Exposome (HELIX) cohort, gestational BPA exposure was associated with increases in DBP and, to a lesser extent, with higher SBP in children ( Warembourg et al., 2019 ). None of the three studies found an association between concurrent child BPA and BP ( Bae et al., 2017 ; Vafeiadi et al., 2016 ; Warembourg et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…In a recent analysis of data from the European Human Early-Life Exposome (HELIX) cohort, gestational BPA exposure was associated with increases in DBP and, to a lesser extent, with higher SBP in children ( Warembourg et al., 2019 ). None of the three studies found an association between concurrent child BPA and BP ( Bae et al., 2017 ; Vafeiadi et al., 2016 ; Warembourg et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Maternal prenatal urinary bisphenol A level and child cardio-metabolic risk factors: A prospective cohort study

Ouyang

Zhang

et al. 2020

Environmental Pollution

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Exposure to endocrine disrupting chemicals during the first 1000 days of life may have long-lasting adverse effects on cardio-metabolic risk in later life. This study aimed to examine the associations between maternal prenatal Bisphenol A (BPA) exposure and child cardio-metabolic risk factors at age 2 years in a prospective cohort. During 2012–2013, 218 pregnant women were enrolled at late pregnancy from Shanghai, China. Urinary BPA concentration was measured in prenatal and child 2-year spot urine samples, and classified into high, medium and low tertiles. Child adiposity anthropometric measurements, random morning plasma glucose, serum insulin, and lipids (high-density lipoprotein, low-density lipoprotein, cholesterol, triglyceride), systolic (SBP) and diastolic blood pressure (DBP) were measured. Linear regression was used to evaluate the associations between prenatal BPA and each of the cardio-metabolic risk factors in boys and girls, respectively, adjusting for pertinent prenatal, perinatal and postnatal factors. BPA was detectable (>0.1 μg/L) in 98.2% of mothers prenatally and 99.4% of children at age 2 years. Compared to those with low prenatal BPA, mean SBP was 7.0 (95%CI: 2.9–11.2) mmHg higher, and DBP was 4.4 (95%CI: 1.2–7.5) mmHg higher in girls with high prenatal BPA levels, but these associations were not found in boys. In boys, medium maternal prenatal BPA level was associated with 0.36 (95% CI: 0.04–0.68) mmol/L higher plasma glucose. No associations were found between prenatal BPA and child BMI, skinfold thicknesses, serum lipids, or insulin in either girls or boys. There were no associations between concurrent child urinary BPA and cardio-metabolic risk factors. These results support that BPA exposure during prenatal period, susceptible time for fetal development, may be associated with increase in child BP and plasma glucose in a sex-specific manner. Further independent cohort studies are needed to confirm the findings.

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Early-Life Environmental Exposures and Blood Pressure in Children

Cited by 115 publications

References 41 publications

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Phthalates Implications in the Cardiovascular System

Maternal prenatal urinary bisphenol A level and child cardio-metabolic risk factors: A prospective cohort study

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