Early life determinants of lung function change from childhood to adolescence

Schultz, Erica S.; Hallberg, Jenny; Andersson, Niklas; Thacher, Jesse D.; Pershagen, Göran; Bellander, Tom; Bergström, Anna; Kull, Inger; Guerra, Stefano; Thunqvist, Per; Gustafsson, Per; Bottai, Matteo; Melén, Erik

doi:10.1016/j.rmed.2018.04.009

Cited by 32 publications

(43 citation statements)

References 51 publications

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“…To the best of our knowledge, this study is the first to evaluate the incidence of FAO in children and adolescents with asthma. Previous studies evaluated the abnormal patterns of lung function from childhood into adulthood, but they did not evaluate FAO 8–15 . Some studies have demonstrated that patients with asthma present patterns of reduced lung function during childhood, 10,12,13,15 while others have shown that reduced lung function occurs only during adulthood 8,9,11 .…”

Section: Discussionmentioning

confidence: 99%

“…It is difficult to compare our results with those of previous studies in the literature because no previous study has evaluated the risk factors for FAO in children and adolescents. There is evidence that BMI, 11,15,30 age, 11,13 second‐hand smoke, 11,15 respiratory tract infection, 15 prematurity, 15 and corticosteroid dose 30 are the main risk factors for patterns of reduced lung function in children and adolescents with asthma. Our results are supported by previous studies with adults suggesting that frequent asthma exacerbation and severe asthma are risk factors for FAO in adults 31,32 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies evaluated the abnormal patterns of lung function from childhood into adulthood, but they did not evaluate FAO. [8][9][10][11][12][13][14][15] Some studies have demonstrated that patients with asthma present patterns of reduced lung function during childhood, 10,12,13,15 while others have shown that reduced lung function occurs only during adulthood. 8,9,11 We consider that our study adds to the literature because all patients had normal lung function at baseline, developed FAO during the follow-up and had clinical treatment established according to the GINA guidelines.…”

Section: Discussionmentioning

confidence: 99%

“…This systematic review included one study with children and adolescents; however, the FAO was not evaluated until the early adult age (around 26 years old) 8 . Other studies have evaluated the patterns of lung function in childhood 9–15 . These studies suggested that patients with asthma may present abnormal patterns of lung function; however, none of them have evaluated FAO.…”

Section: Introductionmentioning

confidence: 99%

“…8 Other studies have evaluated the patterns of lung function in childhood. [9][10][11][12][13][14][15] These studies suggested that patients with asthma may present abnormal patterns of lung function; however, none of them have evaluated FAO. FAO is an important subject because it is associated with mortality in adulthood 9,11,14 and its early detection can avoid lung function deterioration.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4‐Year follow‐up

Sousa

Cabral

Martins

et al. 2020

Pediatric Pulmonology

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Background Asthma is a disease with reversible bronchoconstriction; however, some patients develop fixed airflow obstruction (FAO). Previous studies have reported the incidence and risk factors of FAO in adults; however, the corresponding factors in children remain poorly understood. Aim To evaluate the incidence and risk factors of FAO in children and adolescents with asthma. Method Observational and prospective cohort study with a 4‐year follow‐up of clinically stable patients with asthma (from 6‐8 years old). Anthropometric data, history of asthma, number of hospitalizations, frequent exacerbations, asthma severity, asthma control, inhaled corticosteroid dose, atopy, and lung function were analyzed as potential risk factors for FAO. FAO was defined by a ratio of the forced expiratory volume in the first second to the forced vital capacity below the lower limit of normal, even after inhaled and oral corticosteroid treatment. Results Four hundred and twenty‐eight patients were recruited, and 358 were analyzed. The FAO incidence in children and adolescents with asthma was 9.5% (n = 34), starting at 10 years of age. Age, body mass index, hospitalizations for asthma, bronchodilator response, frequent exacerbations, length of exacerbations, and asthma severity were associated with FAO. Frequent exacerbations (odds ratio [OR] = 4.0; 95% confidence interval [CI] = 1.3‐11.7) and asthma severity categorized as steps 4 to 5 (OR = 3.5; 95% CI = 1.6‐7.6) remained risk factors. Conclusions Frequent exacerbations and asthma severity are the risk factors for FAO in children and adolescents with asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4‐Year follow‐up

Sousa

Cabral

Martins

et al. 2020

Pediatric Pulmonology

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Association of Prenatal and Postnatal Exposures to Warm or Cold Air Temperatures With Lung Function in Young Infants

et al. 2023

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ImportanceLittle is known about long-term associations of early-life exposure to extreme temperatures with child health and lung function.ObjectivesTo investigate the association of prenatal and postnatal heat or cold exposure with newborn lung function and identify windows of susceptibility.Design, Setting, and ParticipantsThis population-based cohort study (SEPAGES) recruited pregnant women in France between July 8, 2014, and July 24, 2017. Data on temperature exposure, lung function, and covariates were available from 343 mother-child dyads. Data analysis was performed from January 1, 2021, to December 31, 2021.ExposuresMean, SD, minimum, and maximum temperatures at the mother-child’s residence, estimated using a state-of-the-art spatiotemporally resolved model.Main Outcomes and MeasuresOutcome measures were tidal breathing analysis and nitrogen multiple-breath washout test measured at 2 months of age. Adjusted associations between both long-term (35 gestational weeks and first 4 weeks after delivery) and short-term (7 days before lung function test) exposure to ambient temperature and newborn lung function were analyzed using distributed lag nonlinear models.ResultsA total of 343 mother-child pairs were included in the analyses (median [IQR] maternal age at conception, 32 [30.0-35.2] years; 183 [53%] male newborns). A total of 246 mothers and/or fathers (72%) held at least a master’s degree. Among the 160 female newborns (47%), long-term heat exposure (95th vs 50th percentile of mean temperature) was associated with decreased functional residual capacity (−39.7 mL; 95% CI, −68.6 to −10.7 mL for 24 °C vs 12 °C at gestational weeks 20-35 and weeks 0-4 after delivery) and increased respiratory rate (28.0/min; 95% CI, 4.2-51.9/min for 24 °C vs 12 °C at gestational weeks 14-35 and weeks 0-1 after delivery). Long-term cold exposure (5th vs 50th percentile of mean temperature) was associated with lower functional residual capacity (−21.9 mL; 95% CI, −42.4 to −1.3 mL for 1 °C vs 12 °C at gestational weeks 15-29), lower tidal volume (−23.8 mL; 95% CI, −43.1 to −4.4 mL for 1 °C vs 12 °C at gestational weeks 14-35 and weeks 0-4 after delivery), and increased respiratory rate (45.5/min; 95% CI, 10.1-81.0/min for 1 °C vs 12 °C at gestational weeks 6-35 and weeks 0-1 after delivery) in female newborns as well. No consistent association was observed for male newborns or short-term exposure to cold or heat.Conclusions and RelevanceIn this cohort study, long-term heat and cold exposure from the second trimester until 4 weeks after birth was associated with newborn lung volumes, especially among female newborns.

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Does birth season influence the odds for asthma? Large cohort analysis

Goldberg

Stein

Picard

et al. 2020

Pediatric Pulmonology

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Background and Objective Few studies have examined the possibility of a link between birth season and the risk for asthma. Those studies that mainly focused on young children, reached different conclusions regarding both the existence of such a link and the season with the highest risk. The purpose of this study was to reinvestigate the relationship between birth season and asthma in a very large cohort, larger than in all previous studies, focusing on adolescents. Methods The medical records of consecutive 17‐year‐old conscripts, born between 1978 and 1999, undergoing medical evaluation before their military service, were reviewed. The prevalence of asthma among conscripts was calculated according to the season of birth. Results Data from 6 26 460 males and 4 54 104 females were collected. Asthma prevalence was 6.6% of the males and 5.8% of the females. Asthma prevalence was highest among those born in the summer and was approximately 9% higher in women and 6% higher in men than those born in the winter. Those born in the winter had the lowest prevalence of asthma. June was the birth month with the highest prevalence of asthma in both genders together with September among males. Conclusions Being born in the summer, especially in June, is associated with an increased risk of asthma compared with a winter birth among Israeli army conscripts. Further research is required to determine the impact of the season of birth on the risk of asthma in higher risk populations.

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Early life determinants of lung function change from childhood to adolescence

Cited by 32 publications

References 51 publications

Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4‐Year follow‐up

Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4‐Year follow‐up

Association of Prenatal and Postnatal Exposures to Warm or Cold Air Temperatures With Lung Function in Young Infants

Does birth season influence the odds for asthma? Large cohort analysis

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