Early-life determinants of asthma from birth to age 20 years: A German birth cohort study

Grabenhenrich, Linus; Gough, Hannah; Reich, Andreas; Eckers, Nora; Zepp, Fred; Nitsche, Oliver; Förster, Johannes; Schuster, Antje; Schramm, Dirk; Bauer, Carl‐Peter; Hoffmann, Ute; Beschorner, John; Wagner, Petra; Bergmann, Renate L.; Bergmann, Karl E.; Matricardi, Paolo Maria; Wahn, Ulrich; Lau, Susanne; Keil, Thomas

doi:10.1016/j.jaci.2013.11.035

Cited by 120 publications

(115 citation statements)

References 48 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…This is in line with a recent report from a German birth cohort, where maternal smoking during pregnancy was associatedwithasthmauptoage20yearsusing time-to-event analyses. 25 In our study, the influence of SHS exposure was strongest on asthma in preschool age, whereas there was no elevated risk for incident cases of asthma at later ages. Recent findings from an Australian birth cohort reported an elevated risk for current asthma at 14 years associated with maternal smoking during pregnancy, 26 which is not supported by our findings.…”

Section: Discussionmentioning

confidence: 40%

Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence

Thacher¹,

Gruzieva²,

Pershagen

et al. 2014

Pediatrics

115

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: Exposure to second-hand tobacco smoke during pregnancy and infancy has been linked to development of asthma, rhinitis, and eczema in young children. It is unclear whether these risks persist into adolescence. WHAT THIS STUDY ADDS:Exposure to second-hand smoke in utero or during infancy influences the development of allergic disease up to adolescence. Excess risks for asthma and rhinitis were seen primarily in early childhood, whereas those for eczema occurred at later ages. abstract OBJECTIVES: To examine the role of prenatal and postnatal secondhand tobacco smoke (SHS) exposure on asthma, rhinitis, and eczema development up to 16 years of age. METHODS:A birth cohort of 4089 children was followed for 16 years. Information on parental smoking habits, lifestyle factors, and symptoms of allergic disease was gathered using repeated parental questionnaires. Generalized estimating equations assessed the overall and age-specific associations between SHS exposure and allergic disease at ages 1 to 16 years.RESULTS: Exposure to SHS in utero was associated with an overall elevated risk of developing asthma up to 16 years (odds ratio [OR] = 1.45; 95% confidence interval [CI], 1.15-1.83) but not for rhinitis or eczema. After additional adjustment for parental smoking throughout childhood, excess overall risks for asthma remained statistically significant. Moreover, a dose-dependent pattern with SHS was observed. Exposure to SHS during infancy was associated with an overall elevated risk of asthma (OR = 1.23; 95% CI, 1.01-1.51), rhinitis (OR = 1.18; 95% CI, 1.01-1.39), and eczema (OR = 1.26; 95% CI, 1.09-1.45) up to 16 years. When age-specific associations were examined, the elevated risks related to SHS exposure in utero or during infancy were mostly confined to early childhood for asthma and rhinitis, whereas the excess risk of eczema appeared greatest at later ages. CONCLUSIONS:Our findings indicate that early SHS exposure, in utero or during infancy, influences the development of allergic disease up to adolescence. Excess risks for asthma and rhinitis were seen primarily in early childhood, whereas those for eczema occurred at later ages.

show abstract

Section: Discussionmentioning

confidence: 40%

Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence

Thacher¹,

Gruzieva²,

Pershagen

et al. 2014

Pediatrics

115

View full text Add to dashboard Cite

show abstract

“…Conversely, two further studies from New Zealand found no association with later-life asthma and allergic sensitisation [27,28]. Recently, the German MAS birth cohort studied possible early-life determinants of asthma in young adulthood and, surprisingly, sleeping on animal fur at 3 months of age was associated with a (statistically nonsignificant) decreased risk of asthma at 20 years of age [15].…”

Section: Discussionmentioning

confidence: 99%

“…Very recently, within the German Multizentrische Allergie Studie (MAS) birth cohort study of early-life determinants of asthma, sleeping on animal fur at 3 months of age was observed to be (not significantly) protective against asthma up to the age of 20 years [15]. We therefore hypothesise that animal furs (e.g.…”

Section: Introductionmentioning

confidence: 90%

Sleeping on animal fur is related to asthma outcomes in later childhood

et al. 2015

View full text Add to dashboard Cite

Animal furs might represent a "proxy" for high and diverse microbial exposures within a critical time window of immune development. We assessed whether sleeping on animal fur shortly after birth is associated with asthma and atopy up to the age of 10 years.LISAplus participants (n=2441) from Munich and Leipzig, Germany, were included in the analysis. Animal fur exposure, cofactors and health outcomes were obtained periodically up to 10 years of age by parental questionnaires. Information on specific IgE to aeroallergens was available at 10 years. Cytokineproducing peripheral T-cells were assessed in a subgroup of children at 2 and 3 years. Confounderadjusted associations were evaluated using logistic regression analyses.Sleeping on animal fur was very common (55%). In adjusted logistic regression analyses, sleeping on animal fur was inversely associated with recurrent early wheezing at 4 years (adjusted OR 0.75, 95% CI 0.61-0.93) and current asthma at 6 years (adjusted OR 0.56, 95% CI 0.31-1.01). Furthermore, sleeping on animal fur during the first 3 months of life was significantly associated with a persistently stimulated interferon-γ response until the age of 3 years.Animal fur could be an effective measure of creating environments associated with higher microbial exposure. @ERSpublications Use of animal fur could be effective for creating environments associated with possibly higher microbial exposure http://ow.ly/IWhTp

show abstract

“…The previously mentioned meta-analysis of 79 prospective studies found an 18-70% higher incidence of wheezing in children exposed to postnatal maternal smoking (OR 1.70 in children f2 years of age) [42]. Prospective birth cohort studies following children up to adult age showed a persistence of the harmful effects of prenatal and postnatal tobacco smoke exposure [46][47][48][49]. In a birth cohort of 1314 children from Germany, maternal smoking during pregnancy almost doubled the risk of asthma at the age of 20 years [49].…”

Section: Second-hand Smoke Exposurementioning

confidence: 96%

“…Prospective birth cohort studies following children up to adult age showed a persistence of the harmful effects of prenatal and postnatal tobacco smoke exposure [46][47][48][49]. In a birth cohort of 1314 children from Germany, maternal smoking during pregnancy almost doubled the risk of asthma at the age of 20 years [49]. A retrospective study examined lung function in 16 832 young adults from the general population, finding that maternal smoking was associated with a small but significant effect on lung function [50].…”

Section: Second-hand Smoke Exposurementioning

confidence: 99%

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

et al. 2014

View full text Add to dashboard Cite

Chronic obstructive respiratory disorders such as asthma and chronic obstructive pulmonary disease often originate early in life. In addition to a genetic predisposition, prenatal and early-life environmental exposures have a persistent impact on respiratory health. Acting during a critical phase of lung development, these factors may change lung structure and metabolism, and may induce maladaptive responses to harmful agents, which will affect the whole lifespan.Some environmental factors, such as exposure to cigarette smoke, type of childbirth and diet, may be modifiable, but it is more difficult to influence other factors, such as preterm birth and early exposure to viruses or allergens.Here, we bring together recent literature to analyse the critical aspects involved in the early stages of lung development, going back to prenatal and perinatal events, and we discuss the mechanisms by which noxious factors encountered early on may have a lifelong impact on respiratory health.We briefly comment on the need for early disease biomarkers and on the possible role of ''-omic'' technologies in identifying risk profiles predictive of chronic respiratory conditions. Such profiles could guide the ideation of effective preventive strategies and/or targeted early lifestyle or therapeutic interventions. @ERSpublications Early-life factors have a role in onset of asthma and COPD; early postnatal interventions may promote lung health http://ow.ly/BvUrx

show abstract

Early-life determinants of asthma from birth to age 20 years: A German birth cohort study

Cited by 120 publications

References 48 publications

Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence

Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence

Sleeping on animal fur is related to asthma outcomes in later childhood

Early-life origins of chronic respiratory diseases: understanding and promoting healthy ageing

Contact Info

Product

Resources

About