Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children

Igra, Annachiara Malin; Vahter, Marie; Raqib, Rubhana; Kippler, Maria

doi:10.1289/ehp3655

Cited by 37 publications

(7 citation statements)

References 48 publications

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“…The results reported in recent years have provided evidence that even low chronic exposure to this metal is hazardous to health [1–4]. The effects of exposure to cadmium involve damage to numerous tissues and organs, including the kidneys [5, 6], liver [7, 8], bone system [9, 10], cardiovascular system [11, 12], and contribute to the development of neoplastic diseases [13, 14] and oral disorders [15–17]. Smoking is the primary source of Cd exposure, especially in relation to oral health, mainly in people living in the areas with low level of cadmium pollution and no occupational exposure.…”

Section: Introductionmentioning

confidence: 99%

The Protective Impact of Black Chokeberry Fruit Extract (Aronia melanocarpaL.) on the Oxidoreductive System of the Parotid Gland of Rats Exposed to Cadmium

Dąbrowska

Onopiuk

et al. 2019

Oxidative Medicine and Cellular Longevity

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Cadmium (Cd) is a strongly toxic heavy metal with prooxidative properties. Since the exposure of the general population to this metal is predicted to increase, effective methods are being sought to prevent its negative actions. One of them involves the use of the antioxidant potential of polyphenol compounds contained in black chokeberry fruit extract and their capability of complex formation with Cd2+. The study objective was to investigate whether the administration of A. melanocarpa fruit extract rich in polyphenol compounds during low and moderate exposures to cadmium can protect the parotid gland against oxidative damage. The study was conducted using the experimental model on female Wistar rats which were given 0.1% aqueous extract of Aronia melanocarpa fruit (AE) and/or cadmium at a concentration of 1 (Cd1) or 5 (Cd5) mg Cd/kg feed for 3 and 10 months, and on control animals. The exposure to Cd attenuated the enzymatic antioxidant barrier (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx)) and increased the concentration of hydrogen peroxide (H2O2), protein carbonyl (PC) groups, and oxidized lipids (LPO) in parotid gland. These disorders led to a reduction in the total antioxidative status (TAS), an increase in the total oxidative state (TOS), and development of stress. The administration of AE at both levels of exposure to cadmium substantially improved the enzymatic antioxidant barrier (CAT, SOD, GPx) and prevented oxidative damage to cellular macromolecules (PC, LPO) and the increase in the level of H2O2, MPO, TOS, and stress indicator (OSI = TOS/TAS) in the parotid gland. Concluding, it should be stated that the consumption of aronia products may prevent oxidative/antioxidative imbalance induced by Cd and oxidative stress development in the parotid gland, thus protecting the gland from damage.

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Section: Introductionmentioning

confidence: 99%

The Protective Impact of Black Chokeberry Fruit Extract (Aronia melanocarpaL.) on the Oxidoreductive System of the Parotid Gland of Rats Exposed to Cadmium

Dąbrowska

Onopiuk

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…In addition to lead exposure, chronic cadmium exposure is also closely related to osteoporosis ( 35 ), and can even affect bone development in children. Malin et al ( 36 ) tested 504 children in a mother-infant cohort in Bangladesh using blood and urine cadmium concentration levels and biomarkers for bone remodeling at the ages of 9 and 4.5, as well as during pregnancy. It was found that cadmium exposure in children caused abnormal bone development, which was negatively correlated with abnormal bone metabolism indicators such as vitamin D3 ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Proximity to major roads and the incidence of osteoporotic fractures in elderly women: The BONE study in Beijing

Ren

Chen

et al. 2022

Front. Public Health

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BackgroundThere is growing evidence to suggest that living near major roads (and suffering from the air pollution of urban streets) can have an adverse effect on bone health. However, little is known about its relationship to fractures caused by osteoporosis.ObjectiveThis study was designed to investigate the relationship between residents living near major roads and the incidence of osteoporotic fractures.MethodsA retrospective cohort of 529 subjects was established based on community populations in older women aged 65–91. All participants lived in Beijing between September 27, 2007 and September 26, 2017. The distance between the residential sites of the subjects and the main roads was determined by the authors. Osteoporotic fracture diagnosis was based on medical histories and imaging examinations (DXA and X-rays). The Cox proportional hazard model was used to assess the association between traffic proximity and osteoporotic fractures, with suitable adjustments for individual and background factors.ResultsThe age range of all participants was 65–91 years, with an average age of 75.8 years (and a standard deviation 6.8 years). Of these, 19 (3.59%) suffered from diabetes, and 48 (9%) had hypertension; 85 (14%) families had annual incomes below US $30,000 and 402 (76%) had received a secondary school education or higher. Nearly 25% of people lived within 50 m of a main road, while 50% lived within 300 m. Between 2007 and 2017, a total of 96 osteoporotic fractures were observed. For people living <50 m from a main road, the adjusted hazard ratio (HR) for osteoporotic fractures was 2.509 (95% CI 1.345–4.680), while it was 1.830 (95% CI 1.029–3.255) for those living at a distance of 50–300 m from a main road vs. those living further than 300 m away.ConclusionIn this community-based cohort, living near a major road was associated with a higher incidence of osteoporotic fractures.

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“… 29 – 33 Furthermore, the exposure to metals has also been assessed at 4.5 and 9 years of age in a smaller subsample of the MINIMat children (born at the hospital in Matlab between June 2003 and June 2004;

at the 9-y follow-up) to evaluate the impact on immune function. 34 , 35 The girls and their mothers in this rural setting are primarily exposed to cadmium through their diet, 36 which is largely based on rice, known to easily take up cadmium from the soil. 18 Lead exposure occurs mainly through food and drinking water, dust, housing materials, and various utensils.…”

Section: Methodsmentioning

confidence: 99%

Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother–Child Cohort Study in Bangladesh

Igra

Rahman

Johansson

et al. 2023

Environ Health Perspect

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Background: Several metals act as endocrine disruptors, but there are few large longitudinal studies about associations with puberty onset. Objectives: We evaluated whether early life cadmium, lead, and arsenic exposure was associated with timing of menarche. Methods: In a mother–child cohort in rural Bangladesh ( ), the exposure was assessed by concentrations in maternal erythrocytes in early pregnancy and in girls’ urine at 5 and 10 years of age using inductively coupled plasma mass spectrometry. The girls were interviewed twice, at average ages 13.3 [standard deviation ] and 13.8 ( ) y, and the date of menarche, if present, was recorded. Associations were assessed using Kaplan–Meier analysis and multivariable-adjusted Cox regression. Results: In total, 77% of the girls ( ) had reached menarche by the second follow-up. The median age of menarche among all girls was 13.0 y (25th–75th percentiles: 12.4–13.7 y). At 10 years of age, median urinary cadmium was (5th–95th percentiles: ), lead ( ), and arsenic ( ). Given the same age, girls in the highest quartile of urinary cadmium at 5 and 10 years of age had a lower rate of menarche than girls in the lowest quartile, with an adjusted hazard ratio of (HR) 0.80 (95% CI: 0.62, 1.01) at 5 years of age, and 0.77 (95% CI: 0.60, 0.98) at 10 years of age. This implies that girls in the highest cadmium exposure quartile during childhood had a higher age at menarche. Comparing girls in the highest to the lowest quartile of urinary lead at 10 years of age, the former had a higher rate of menarche [adjusted 1.23 (95% CI: 0.97, 1.56)], implying lower age at menarche, whereas there was no association with urinary lead at 5 years of age. Girls born to mothers in the highest quartile of erythrocyte arsenic during pregnancy were less likely to have attained menarche than girls born to mothers in the lowest quartile [adjusted 0.79 (95% CI: 0.62, 0.99)]. No association was found with girls’ urinary arsenic exposure. Discussion: Long-term childhood cadmium exposure was associated with later menarche, whereas the associations with child lead exposure were inconclusive. Maternal exposure to arsenic, but not cadmium or lead, was associated with later menarche. https://doi.org/10.1289/EHP11121

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Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children

Cited by 37 publications

References 48 publications

The Protective Impact of Black Chokeberry Fruit Extract (Aronia melanocarpaL.) on the Oxidoreductive System of the Parotid Gland of Rats Exposed to Cadmium

The Protective Impact of Black Chokeberry Fruit Extract (Aronia melanocarpaL.) on the Oxidoreductive System of the Parotid Gland of Rats Exposed to Cadmium

Proximity to major roads and the incidence of osteoporotic fractures in elderly women: The BONE study in Beijing

Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother–Child Cohort Study in Bangladesh

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