Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort

Blomberg, Annelise J.; Shih, Yu-Hsuan; Messerlian, Carmen; Jørgensen, Louise Helskov; Weihe, Pál; Grandjean, Philippe

doi:10.1016/j.envres.2021.111400

Cited by 42 publications

(15 citation statements)

References 54 publications

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“…2018 ). A recent study also showed PFAS exposures were related to cholesterol metabolism with significant differences in sex ( Blomberg et al. 2021 ).…”

Section: Discussionmentioning

confidence: 96%

“…Environmental Health Perspectives 037006-7 130(3) March 2022 (Li et al 2017;Manzano-Salgado et al 2017), whereas others suggested that girls could be more vulnerable (Cao et al 2018;Chen et al 2019;Kashino et al 2020;Kishi et al 2015), and some reported no obvious sex differences (Bach et al 2016;Gyllenhammar et al 2018). A recent study also showed PFAS exposures were related to cholesterol metabolism with significant differences in sex (Blomberg et al 2021). The modification effects by child sex should be considered in future studies.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

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Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years

Gao

Luo

Zhang

et al. 2022

Environ Health Perspect

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Background: Pregnant women are ubiquitously exposed to per- and polyfluoroalkyl substances (PFAS). Prenatal exposure to PFAS has been associated with lower birth weight but also with excess adiposity and higher weight in childhood. These mixed findings warrant investigation of the relationship between PFAS and dynamic offspring growth. Objectives: To investigate the association between prenatal PFAS exposure and early-life growth trajectories during the first 2 y. Methods: Pregnant women ( ) were recruited from 2013 to 2016 from the Shanghai Birth Cohort (SBC) Study, and their children were followed up from birth to 2 y of age. Seven PFAS congeners were quantified in pregnant women’s serum during the first trimester. Our study population was restricted to 1,350 children who had five repeated measurements for at least one anthropometric measure. Four anthropometric measures, including weight, length/height, weight-for-length, and head circumference, were evaluated at birth, 42 d, 6 months, 12 months, and 24 months, and standardized into z -scores using the World Health Organization reference. Trajectories of each measure were classified into five groups using group-based trajectory modeling. Multinomial logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) for trajectory groups according to -transformed PFAS concentrations, and the moderate-stable group was selected as the reference group for all measures. Results: Higher prenatal exposure to PFAS was associated with elevated odds for the low-rising weight-for-age z -score (WAZ) trajectory, and the high-rising length-for-age z -score (LAZ) trajectory. Meanwhile, PFAS levels were associated with decreased odds for the low-rising and high-rising weight-for-length z -score (WLZ) trajectories. In addition, the associations of PFAS with growth trajectory groups differed by sex, where males had greater odds for the low-rising and low-stable WAZ trajectories and for the high-stable and low-rising WLZ trajectories. In contrast, inverse associations were consistently observed with trajectories of the high-stable, low-stable, and low-rising head-circumference-for-age z -score (HCZ) in relation to most individual PFAS congeners. PFAS mixtures analysis further confirmed the above findings. Discussion: Trajectory analysis approach provided insight into the complex associations between PFAS exposure and offspring growth. Future studies are warranted to confirm the present findings with trajectory modeling strategies and understand the clinical significance of these trajectory groups. https://doi.org/10.1289/EHP9875

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“…2018 ). A recent study also showed PFAS exposures were related to cholesterol metabolism with significant differences in sex ( Blomberg et al. 2021 ).…”

Section: Discussionmentioning

confidence: 96%

Section: Environmental Health Perspectivesmentioning

confidence: 99%

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years

Gao

Luo

Zhang

et al. 2022

Environ Health Perspect

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“…A monitoring study by Zheng et al showed that PFAS are routinely detected in breast milk in the United States, demonstrating the scope of this potential concern [ 83 ]. Beyond lactation, numerous recent studies have shown that PFAS are frequently detected in cord blood samples, indicating that there is ubiquitous fetal exposure to PFAS globally [ 84 , 85 , 86 , 87 , 88 , 89 ]. Though the majority of the studies included in this scoping review focused upon adults, more studies are needed to elucidate whether these fetal and infant exposures may increase risk for diabetes in children.…”

Section: Discussionmentioning

confidence: 99%

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Margolis

Sant

2021

JoX

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Per- and polyfluoroalkyl substances (PFASs) are persistent environmental pollutants that are commonly found in the human body due to exposures via drinking water, surfactants used in consumer materials, and aqueous film-forming foams (AFFFs). PFAS exposure has been linked to adverse health effects such as low infant birth weights, cancer, and endocrine disruption, though increasingly studies have demonstrated that they may perturb metabolic processes and contribute to dysfunction. This scoping review summarizes the chemistry of PFAS exposure and the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of diabetes, hyperglycemia, and/or insulin resistance. We identified 11 studies on gestational diabetes mellitus, 3 studies on type 1 diabetes, 7 studies on type 2 diabetes, 6 studies on prediabetes or unspecified diabetes, and 15 studies on insulin resistance or glucose tolerance using the SCOPUS and PubMed databases. Approximately 24 reported positive associations, 9 negative associations, 2 non-linear associations, and 2 inverse associations, and 8 reported no associations found between PFAS and all diabetes search terms. Cumulatively, these data indicate the need for further studies to better assess these associations between PFAS exposure and diabetes.

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“… 11 PFAS exposure during sensitive periods of development, such as childhood or adolescence, is of particular concern because this is an important developmental stage for cellular differentiation and development of metabolic tissues. 12 – 15 Longitudinal studies have found that PFAS exposure during childhood is associated with the development of dysregulated glucose metabolism and insulin resistance, 16 , 17 dyslipidemia, 18 and adiposity. 19 , 20 Similar associations have been observed in adults, suggesting that these associations persist into adulthood.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study

Goodrich

Walker

et al. 2023

Environ Health Perspect

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Background: Exposure to per- and polyfluoroalkyl substances (PFAS) is ubiquitous and has been associated with an increased risk of several cardiometabolic diseases. However, the metabolic pathways linking PFAS exposure and human disease are unclear. Objective: We examined associations of PFAS mixtures with alterations in metabolic pathways in independent cohorts of adolescents and young adults. Methods: Three hundred twelve overweight/obese adolescents from the Study of Latino Adolescents at Risk (SOLAR) and 137 young adults from the Southern California Children’s Health Study (CHS) were included in the analysis. Plasma PFAS and the metabolome were determined using liquid-chromatography/high-resolution mass spectrometry. A metabolome-wide association study was performed on log-transformed metabolites using Bayesian regression with a g-prior specification and g-computation for modeling exposure mixtures to estimate the impact of exposure to a mixture of six ubiquitous PFAS (PFOS, PFHxS, PFHpS, PFOA, PFNA, and PFDA). Pathway enrichment analysis was performed using Mummichog and Gene Set Enrichment Analysis. Significance across cohorts was determined using weighted -tests. Results: In the SOLAR and CHS cohorts, PFAS exposure was associated with alterations in tyrosine metabolism (meta-analysis ) and de novo fatty acid biosynthesis ( ), among others. For example, when increasing all PFAS in the mixture from low ( th percentile) to high ( th percentile), thyroxine (T4), a thyroid hormone related to tyrosine metabolism, increased by 0.72 standard deviations (SDs; equivalent to a standardized mean difference) in the SOLAR cohort (95% Bayesian credible interval (BCI): 0.00, 1.20) and 1.60 SD in the CHS cohort (95% BCI: 0.39, 2.80). Similarly, when going from low to high PFAS exposure, arachidonic acid increased by 0.81 SD in the SOLAR cohort (95% BCI: 0.37, 1.30) and 0.67 SD in the CHS cohort (95% BCI: 0.00, 1.50). In general, no individual PFAS appeared to drive the observed associations. Discussion: Exposure to PFAS is associated with alterations in amino acid metabolism and lipid metabolism in adolescents and young adults. https://doi.org/10.1289/EHP11372

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Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort

Cited by 42 publications

References 54 publications

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Metabolic Signatures of Youth Exposure to Mixtures of Per- and Polyfluoroalkyl Substances: A Multi-Cohort Study

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