Early life adversity drives sex-specific anhedonia and meningeal immune gene expression through mast cell activation

Duque-Wilckens, Natalia; Teis, Robby; Sarno, Erika; Stoelting, Frauke; Khalid, Sonia; Dairi, Zakaria; Douma, Alex; Maradiaga, Nidia; Hench, Stina; Dharshika, Christine; Thelen, Kyan; Gulbransen, Brian D.; Robison, Alfred J.; Moeser, Adam J.

doi:10.1016/j.bbi.2022.03.009

Cited by 6 publications

(13 citation statements)

References 129 publications

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“…The current results are not consistent with a recent report demonstrating that the combination of early life MS with early weaning increases susceptibility to adult-stress-induced changes in the sucrose preference test ( Duque-Wilckens et al, 2022 ). There are many procedural differences between these studies that likely explain the apparent discrepancy.…”

Section: Discussioncontrasting

confidence: 99%

“…Several prior studies in rodents have also supported the stress inoculation hypothesis by reporting protective effects of brief or mild ELS ( Hsiao et al, 2016 ; Calpe-Lopez et al, 2022 ). However, other studies have suggested that similar ELS procedures promote susceptibility to subsequent stressors ( Pena et al, 2017 ; Hultman et al, 2018 ; Duque-Wilckens et al, 2022 ). The reasons for these disparate outcomes following ELS and adult stress are not known, but they could involve unidentified genetic (or other) factors, consistent with the three-hit-hypothesis of vulnerability vs. resilience ( Daskalakis et al, 2013 ).…”

Section: Discussionmentioning

confidence: 95%

“…The intensity of ELS in the previous study was likely further magnified by the early weaning on day 17. Importantly, even the more severe ELS model did not have any significant effects on sucrose preference on its own ( Duque-Wilckens et al, 2022 ), but it did predispose animals to sucrose preference reductions following an adult stressor.…”

Section: Discussionmentioning

confidence: 99%

“…While sub-chronic stress paradigms lasting 5 or 6 days are consistently reported to induce behavioral phenotypes in at least one sex ( Hodes et al, 2015 ; Baugher et al, 2022 ), 3 days of variable stress exposure has generally been reported to be insufficient to alter behavior ( Hodes et al, 2015 ; Duque-Wilckens et al, 2022 ). However, experimental manipulations have been shown to confer vulnerability to 3 days of stress exposure in mice.…”

Section: Introductionmentioning

confidence: 99%

“…For example, one recent study reported that female mice exposed to 3 days of stress in adulthood following ELS (MS plus early weaning) have reduced sucrose preference compared to mice exposed to 3 days of stress in adulthood without a history of ELS. Importantly, neither ELS nor 3 days of adult stress alone led to reductions in sucrose preference ( Duque-Wilckens et al, 2022 ). The current study was designed to determine whether MS influences susceptibility to an abbreviated 3-day version of the 5-day variable stress paradigm (5DS) our lab has recently published ( Baugher et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Early life maternal separation induces sex-specific antidepressant-like responses but has minimal effects on adult stress susceptibility in mice

Baugher

Sachs

2022

Front. Behav. Neurosci.

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Early life stress is known to increase the risk of depression and anxiety disorders, which are highly prevalent conditions that disproportionately affect women. However, the results of preclinical studies have been mixed, with some work suggesting that early life stress promotes anxiety-like behavior and/or increases susceptibility to subsequent stressors, and other research suggesting that early life stress reduces anxiety-like behavior and/or confers resilience to subsequent stress exposure. It is likely that factors such as sex and the timing and severity of early life and adult stress exposure dictate whether a particular early life experience promotes adaptive vs. maladaptive behavior later in life. Most work in this area has focused exclusively on males, but several sex differences in the effects of early life stress on subsequent stress susceptibility have been reported. The current study examined the impact of early life maternal separation on susceptibility to behavioral alterations induced by 3 days of variable stress in adulthood in male and female c57BL6 mice. Our results indicate that 3 days of adult stress is sufficient to increase anxiety-like behavior in several paradigms and to increase immobility in the forced swim test. In contrast, a history of maternal separation reduces anxiety-like behavior in several tests, particularly in males. These findings could contribute to our understanding of sex differences in mental illness by demonstrating that males are more likely than females to display adaptive responses to mild early life stressors.

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Section: Discussioncontrasting

confidence: 99%