Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction

Abstract

The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in the study. Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases. All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram. Results. The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects. Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. Tissue Doppler derived S′ amplitude of lateral part at mitral valve (S′Lm) and E′ wave amplitudes both at the lateral (E′Lm) and septal parts of the mitral valve (E′Sm) were significantly lower in OSA patients compared to controls. Conclusion. Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function. OSA is independently associated with these changes in LV function.

Biotype characterization of Staphylococcus aureus from milk and dairy products of private production in the western regions of Ukraine

“…Результати цих досліджень опосередковано можуть пояснити знайдені в нашому експерименті ехокардіографічні зміни. За даними Danica et al (2014), істотний внесок в ураження міокарда лівого шлуночка за СОАС робить підвищення трансмурального тиску в лівому передсерді та лівому шлуночку внаслідок коливань внутрішньогрудного тиску, що відбувається протягом епізоду апное-гіпопное як результат марних дихальних зусиль. У випадку ожиріння одним із провідних патогенетичних факторів уважається збільшення об'єму циркулюючої крові, що спричинює перенавантаження лівого шлуночка (Leopoldo et al, 2010;Usui, 2013).…”

Effects of Exercise Training on Left Ventricular Diastolic Function Markers in Patients with Obstructive Sleep Apnea: A Randomized Study

“…IVRT represents the interval between closure of the aortic valve and opening of the mitral valve 22 and is influenced by intraventricular mitral and aortic pressure gradients. Danica et al 23 reported that in the early stages of diastolic dysfunction, IVRT increases in patients with OSA compared to patients without OSA. Prolonged IVRT has also been used by several authors as an indicator of impaired LV diastolic function in patients with OSA compared to controls.…”

Advances in screening for undiagnosed atrial fibrillation for stroke prevention and implications for patients with obstructive sleep apnoea: a literature review and research agenda

“…Other studies have also shown that the onset and duration of OSA-triggered AF can be reduced or inhibited by renal sympathetic denervation or pharmacologic inhibition of the renin-angiotensin pathway [44], although the therapeutic implications of these findings remain unclear. OSA may also induce chronic cardiac remodelling and diastolic dysfunction which may increase the risk of AF [45][46][47][48]. Systemic inflammation and oxidative stress, induced by OSA, have also been hypothesised to increase the risk of AF [49,50].…”