Early left periventricular brain lesions induce right hemispheric organization of speech

Staudt, Martin; Grodd, Wolfgang; Niemann, Gerhard; Wildgruber, Dirk; Erb, Michael; Krägeloh‐Mann, Ingeborg

doi:10.1212/wnl.57.1.122

Cited by 129 publications

(129 citation statements)

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“…These factors may include demographic and clinical characteristics of patients, such as the age at which the lesion or epileptic seizures occur (Vargha-Khadem et al, 1997;Staudt et al, 2001;Hertz-Pannier et al, 2002;Liégeois et al, 2004;Brázdil et al, 2005;Tracy et al, 2009), the size, location, and lateralization of the EZ (Adcock et al, 2003;Backes et al, 2005;Berl et al, 2005;Karunanayaka et al, 2011), frequency of interictal epileptiform discharges (Janszky et al, 2003(Janszky et al, , 2006, gender (Strauss et al, 1992;Helmstaedter et al, 2004), handedness (Berl et al, 2014), and individual differences in potential plasticity (Zatorre, 2013). Furthermore, the pattern of organization may be different before and after surgery (Helmstaedter et al, 2006;Bonelli et al, 2012;Perrone-Bertolotti et al, 2012a).…”

Section: Factors Modulating Language Plasticity In Epilepsy Patientsmentioning

confidence: 99%

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Baciu

Perrone‐Bertolotti

2015

Reviews in the Neurosciences

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AbstractThe objective of this review is to resume major neuroimaging findings on language organization and plasticity in patients with focal and refractory epilepsy, to discuss the effect of modulatory variables that should be considered alongside patterns of reorganization, and to propose possible models of language reorganization. The focal and refractory epilepsy provides a real opportunity to investigate various types of language reorganization in different conditions. The ‘chronic’ condition (induced by the epileptogenic zone or EZ) is associated with either recruitment of homologous regions of the opposite hemisphere or recruitment of intrahemispheric, nonlinguistic regions. In the ‘acute’ condition (neurosurgery and EZ resection), the initial interhemispheric shift (induced by the chronic EZ) could follow a reverse direction, back to the initial hemisphere. These different patterns depend on several modulatory factors and are associated with various levels of language performance. As a neuroimaging tool, functional magnetic resonance imaging enables the detailed investigation of both hemispheres simultaneously and allows for comparison with healthy controls, potentially creating a more comprehensive and more realistic picture of brain-language relations. Importantly, functional neuroimaging approaches demonstrate a good degree of concordance on a theoretical level, but also a considerable degree of individual variability, attesting to the clinical importance with these methods to establish, empirically, language localization in individual patients. Overall, the unique features of epilepsy, combined with ongoing advances in technology, promise further improvement in understanding of language substrate.

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Section: Factors Modulating Language Plasticity In Epilepsy Patientsmentioning

confidence: 99%

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Baciu

Perrone‐Bertolotti

2015

Reviews in the Neurosciences

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“…In both systems, the 'afferent' components (somatosensory hand representation ⁄ perception of speech) can still be located in the affected hemisphere, whereas the 'efferent' components (motor hand representation ⁄ production of speech) are (re)organized in the contralesional hemisphere (Staudt et al 2001;Staudt, 2007). Moreover, the degree of right-hemispheric takeover of language production has been demonstrated to be related to structural damage to left-hemispheric facial motor tracts with their well-known relevance for articulation (Staudt et al 2001(Staudt et al , 2008.…”

Section: Reorganization In the Language Systemmentioning

confidence: 99%

Reorganization after pre‐ and perinatal brain lesions*

2010

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The developing human brain can compensate for pre-and perinatally acquired focal lesions more effectively than the adult brain. The mechanisms by which this effective reorganization is achieved vary considerably between different functional systems, reflecting differences in the normal maturation of these systems. In the motor system, descending cortico-spinal motor projections have already reached their spinal target zones at the beginning of the third trimester of pregnancy, with initially bilateral projections from each hemisphere. During normal development, the ipsilateral projections are gradually withdrawn, whereas the contralateral projections persist. When, during this period, a unilateral brain lesion disrupts the cortico-spinal projections of one hemisphere, the ipsilateral projections from the contralesional hemisphere will persist. This allows the contralesional hemisphere to take over motor control over the paretic extremities. Although this mechanism of reorganization is available throughout the pre-and perinatal period, the efficacy of this ipsilateral takeover of motor functions decreases with increasing age at the time of the insult. In the somatosensory system, ascending thalamo-cortical somatosensory projections have not yet reached their cortical target zones at the beginning of the third trimester of pregnancy. Therefore, these projections can still 'react' to brain lesions acquired during this period, and can form 'axonal bypasses' around periventricular white matter lesions to reach their original cortical target areas in the postcentral gyrus. Thus, somatosensory functions can be well preserved even in cases of large periventricular lesions. In contrast, when the postcentral gyrus itself is affected, no signs for reorganization have been observed. Accordingly, somatosensory functions are often poor in these patients. Language functions can be normal even in patients with extensive early left-hemispheric brain lesions. This is achieved by language organization in the right hemisphere, which takes place in brain regions homotopic to the classical left-hemispheric language areas in normal subjects. In patients with periventricular lesions, the degree of right-hemispheric takeover of language functions correlates with the severity of structural damage to facial (and, thus, articulatory) motor projections.

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“…The majority of patients in this group had left seizure focus, was left-handed, and had left structural lesions, all factors known to be associated with atypical language domina e identified two groups with left hemisphere patterns of activati nce (Gaillard et al, 2007;Woermann et al, 2003). While activation in this group occurred in the right hemisphere in areas that mirror activation seen in the lefthemisphere patterns (Gaillard et al, 2002;Mbwana et al, 2009;Rosenberger et al, 2009;Staudt et al, 2001) -this group also showed the greatest variance. Some studies suggest that atypical language dominance in patient populations is tightly constrained to right homologues (Rosenberger et al, 2009;Staudt et al, 2001) but others suggest greater variability when language has shifted to the typically non-dominant hemisphere (Voets et al, 2006).…”

Section: Discussionmentioning

confidence: 70%

“…While activation in this group occurred in the right hemisphere in areas that mirror activation seen in the lefthemisphere patterns (Gaillard et al, 2002;Mbwana et al, 2009;Rosenberger et al, 2009;Staudt et al, 2001) -this group also showed the greatest variance. Some studies suggest that atypical language dominance in patient populations is tightly constrained to right homologues (Rosenberger et al, 2009;Staudt et al, 2001) but others suggest greater variability when language has shifted to the typically non-dominant hemisphere (Voets et al, 2006). These patterns are considered to represent "reorganization" from the left to the right hemisphere in response to epilepsy or its remote cause (Gaillard et al, 2007;Mbwana et al, 2009).…”

Section: Discussionmentioning

confidence: 70%

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Principal Component Analysis and Assessment of Language Network Activation Patterns in Pediatric Epilepsy

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Early left periventricular brain lesions induce right hemispheric organization of speech

Cited by 129 publications

References 9 publications

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

What do patients with epilepsy tell us about language dynamics? A review of fMRI studies

Reorganization after pre‐ and perinatal brain lesions*

Principal Component Analysis and Assessment of Language Network Activation Patterns in Pediatric Epilepsy

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